Computed tomographic imaging of the airways: relationship to structure and function
Abstract
Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.
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Radiographic techniques are not commonly used clinically to measure static hyperinflation in COPD because of a lack of standardization.
“Finally, because of a lack of standardization, radiographic techniques144–147 are not commonly used clinically to measure static hyperinflation in COPD.32”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [147]
Cites
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TGF-β1 Signaling and Tissue Fibrosis
Kim, K. K., Sheppard, D., & Chapman, H. A. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022293 · Cited by 800 · see citing works
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Pathogenesis of hyperinflation in chronic obstructive pulmonary disease
Saey, Gagnon, P., Guenette, J., Langer, D., Laviolette, L., Mainguy, V., Maltais, F., & Ribeiro, F. (2014) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s38934 · Cited by 180 · see citing works
“141 Finally, because of a lack of standardization, radiographic techniques 144–147 are not commonly used clinically to measure static hyperinflation in COPD.”
- Authors
- de Jong, P. A., Müller, N. L., Paré, P. D., & Coxson, H. O.
- ORCID
- Coxson, H. O.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2005-07
- Volume
- 26
- Issue
- 1
- Pages
- 140-152
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2118374190
- Cited by
- 171
- References
- 2
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 12 · 2013: 12 · 2012: 12
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- airway remodeling, computed tomography, airflow obstruction, chronic lung disease, non-invasive imaging, airway wall thickening
- MeSH terms
- Airway Obstruction, Airway Resistance, Asthma, Bronchi, Female, Humans, Image Processing, Computer-Assisted, Male, Sensitivity and Specificity, Severity of Illness Index, Tomography, X-Ray Computed, Pulmonary Disease, Chronic Obstructive
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