Skeletal Muscle Inflammation and Nitric Oxide in Patients with COPD
Open accessAbstract
In chronic obstructive pulmonary disease (COPD) the presence of systemic inflammation has been associated with peripheral muscle abnormalities and weight loss. To study whether inflammatory factors are important in these processes, the present study compared the skeletal muscle levels of nitrite, nitrate, nitrotyrosine, neuronal, endothelial and inducible nitric oxide synthases (nNOS, eNOS, and iNOS, respectively), and inflammatory markers (tumour necrosis factor (TNF)-α, CD154 and CD163) in 15 patients (forced expiratory volume in one second 43±11%) and 14 controls. All these markers were also compared between patients with normal and low body weight. Nitrite (12.5±2.6 versus 17.0±3.4 μmol·mg−1 protein), nitrate (20.7±2.4 versus 24.4±4.5 μmol·mg−1 protein) and eNOS (31.9±4.6 versus 43.6±7.5 ng·mg−1 protein) were lower in COPD patients than in controls. Nitrotyrosine (25.6±5.4 versus 6.6±3.3 ng·mg−1 protein), iNOS expression (32±9.5 versus 7.16±2.7 ng·mg−1 protein), TNF-α (257±160 versus 48.3±4.4 pg·mg−1 protein) and CD163 (6.4±2.1 versus 0.8±0.4 ng·mg−1 protein) were higher in COPD patients than in controls. CD154 levels were 15.7±7.0 ng·mg−1 protein in COPD patients and undetectable in controls. Similar levels of all these markers were observed in COPD patients with normal and low body weight. In conclusion, these findings suggest the presence of an inflammatory process in the muscle tissue of chronic obstructive pulmonary disease patients, and argue in favour of its participation in the pathogenesis of skeletal muscle abnormalities.
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In the quadriceps of COPD patients, muscular TNF-α levels have been reported as significantly elevated, decreased, and unaltered, or even undetected at the protein level.
“with regards to muscular TNF-α, significantly elevated, decreased, and unaltered levels have been reported in the quadriceps of COPD patients [27,28,29], or even undetected at the protein level [30,31]”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [29]
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- Authors
- Montes de Oca, M., Torres, S. H., De Sanctis, J., Mata, A., Hernández, N., & Tálamo, C.
- Affiliations
- Universidad Central de Venezuela (VE)
- Hospital Clínico Universitario de Caracas (VE)
- ORCID
- Torres, S. H.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2005-09
- Volume
- 26
- Issue
- 3
- Pages
- 390-397
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2102139058
- Cited by
- 123
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 10
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional para Investigaciones Científicas y Tecnológicas
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- chronic obstructive pulmonary disease, skeletal muscle inflammation, nitric oxide, nitrite, nitrate, nitrotyrosine, inducible nitric oxide synthase, endothelial nitric oxide synthase, neuronal nitric oxide synthase, TNF-α, CD163, CD154, muscle atrophy, systemic inflammation
- MeSH terms
- Aged, Body Weight, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Nitric Oxide, Respiratory Function Tests, Tumor Necrosis Factor-alpha, Antigens, CD, Case-Control Studies, Muscle, Skeletal, Inflammation Mediators, Nitric Oxide Synthase, Pulmonary Disease, Chronic Obstructive
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