The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections
Abstract
Viral infection may induce the expression of nitric oxide (NO) synthase, resulting in increased NO formation that has an antiviral effect. NO may be produced by various cells of the upper and lower respiratory tract, and may be detected in the exhaled air. We have studied the levels of exhaled NO in 18 normal subjects during symptomatic upper respiratory tract infections and during recovery 3 weeks later. Exhaled NO was measured using a modified chemiluminescence analyser. At the time of symptoms of upper respiratory tract infection, the peak exhaled NO values were 315 +/- 57 ppb (mean +/- SEM) and decreased to 87 +/- 9 ppb during recovery. Recovery values of exhaled NO were similar to those reported in age-matched normal control subjects (88 +/- 3 ppb, n = 72). These findings suggest that symptomatic upper respiratory tract infections markedly increase the concentration of NO in exhaled air. This may reflect the induction of nitric oxide synthase (NOS) in upper and lower respiratory tract, and may be relevant to viral exacerbations of asthma.
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Cites
Respiratory viruses and exacerbations of asthma in adults
Nicholson, K. G., Kent, J., & Ireland, D. C. (1993) · BMJ · doi:10.1136/bmj.307.6910.982 · Cited by 1,127
Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P., & Moncada, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91268-h · Cited by 964
The biology of nitrogen oxides in the airways
Gaston, B., Drazen, J. M., Loscalzo, J., & Stamler, J. S. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.7508323 · Cited by 918 · cited 1×
“Nitric oxide (NO) is important as a signalling molecule, and may play a key role in host defence and in the pathophysiology of airway diseases [1–3].”
Background
Cited by
(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-710st · Cited by 3,203
(1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.ats8-99 · Cited by 771
Inducible Nitric Oxide Synthase and Inflammatory Diseases
Zamora, R., Vodovotz, Y., & Billiar, T. R. (2000) · Molecular Medicine · doi:10.1007/bf03401781 · Cited by 558
Exhaled nitric oxide measurements: clinical application and interpretation
Taylor, D. R., Pijnenburg, M. W., Smith, A. D., & Jongste, J. C. D. (2006) · Thorax · doi:10.1136/thx.2005.056093 · Cited by 507
Review—Non-Invasive Monitoring of Human Health by Exhaled Breath Analysis: A Comprehensive Review
Das, S., & Pal, M. (2020) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ab67a6 · Cited by 466
Metadata
- Authors
- Kharitonov, S., Yates, D., & Barnes, P.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 1995-02-01
- Volume
- 8
- Issue
- 2
- Pages
- 295-297
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2046231908
- Cited by
- 410
- References
- 3
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kharitonov, S., Yates, D., & Barnes, P. (1995). Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. European Respiratory Journal. https://doi.org/10.1183/09031936.95.08020295
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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