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Cited by 80Chronic Obstructive Pulmonary Disease (COPD) ResearchMicroRNA in disease regulationAsthma and respiratory diseases

Unravelling the Complexity of COPD by MicroRNAs: It’s a Small World after All

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Osei, Emmanuel T., Florez-Sampedro, Laura, Timens, Wim, Postma, Dirkje S., Heijink, Irene H., Brandsma, Corry-Anke·2015·European Respiratory Journal
DOI 10.1183/13993003.02139-2014
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Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease and is currently the fourth leading cause of death worldwide. Chronic inflammation and repair processes in the small airways are characteristic of COPD. Despite extensive efforts from researchers and industry, there is still no cure for COPD, hence an urgent need for new therapeutic alternatives. MicroRNAs are such an option; they are small noncoding RNAs involved in gene regulation. Their importance has been shown with respect to maintaining the balance between health and disease. Although previous reviews have discussed the expression of microRNAs related to lung disease, a detailed discussion regarding the function of differential miRNA expression in the pathogenesis of COPD is lacking. In this review we link the expression of microRNAs to different features of COPD and explain their importance in the pathogenesis of this disease. We further discuss their potential to contribute to the development of future therapeutic strategies.

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Cited by

Sorted by citations

Authors
Osei, E. T., Florez-Sampedro, L., Timens, W., Postma, D. S., Heijink, I. H., & Brandsma, C.-A.
Affiliations
University Medical Center Groningen (NL)
ORCID
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2015-08-06
Volume
46
Issue
3
Pages
807-818
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/13993003.02139-2014
OpenAlex
W2148094819
Cited by
80
References
0
Citations by year
2026: 6 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 13 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 13 · 2016: 2 · 2015: 3
FWCI
1.54
Type
journal article
Language
en
Open access
Locations
  • European Respiratory Journal (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords
chronic obstructive pulmonary disease, microRNA, microRNA expression, COPD pathogenesis, small airways, chronic inflammation, gene expression regulation, therapeutic target
MeSH terms
Adult, Aged, Animals, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Prognosis, Smoking, Disease Progression, Risk Assessment, Pulmonary Disease, Chronic Obstructive, MicroRNAs, Molecular Targeted Therapy, Real-Time Polymerase Chain Reaction

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