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Cited by 48Asthma and respiratory diseasesGenetic Associations and EpidemiologyChronic Obstructive Pulmonary Disease (COPD) Research

Asthma and affective traits in adults: a genetically informative study

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Lehto, Kelli, Pedersen, Nancy L., Almqvist, Catarina, Lu, Yi, Brew, Bronwyn K.·2019·European Respiratory Journal
DOI 10.1183/13993003.02142-2018

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Abstract

Depression, anxiety and high neuroticism (affective traits) are often comorbid with asthma. A causal direction between the affective traits and asthma is difficult to determine; however, there may be a common underlying pathway attributable to shared genetic factors. Our aim was to determine whether a common genetic susceptibility exists for asthma and each of the affective traits. An adult cohort from the Swedish Twin Registry underwent questionnaire-based health assessments (n=23 693) and genotyping (n=15 908). Firstly, questionnaire-based associations between asthma and affective traits were explored. This was followed by genetic analyses: 1) polygenic risk scores (PRS) for affective traits were used as predictors of asthma in the cohort, and 2) genome-wide association results from UK Biobank were used in linkage-disequilibrium score regression (LDSC) to quantify genetic correlations between asthma and affective traits. Analyses found associations between questionnaire-based asthma and affective traits (OR 1.67, 95% CI 1.50–1.86 major depression; OR 1.45, 95% CI 1.30–1.61 anxiety; and OR 1.60, 95% CI 1.40–1.82 high neuroticism). Genetic susceptibility for neuroticism explained the variance in asthma with a dose–response effect; that is, study participants in the highest neuroticism PRS quartile were more likely to have asthma than those in the lowest quartile (OR 1.37, 95% CI 1.17–1.61). Genetic correlations were found between depression and asthma (r g =0.17), but not for anxiety or neuroticism. We conclude that the observed comorbidity between asthma and the affective traits may in part be due to shared genetic influences between asthma and depression (LDSC) and neuroticism (PRS), but not anxiety.

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Cited by

Sorted by citations

Authors
Lehto, K., Pedersen, N. L., Almqvist, C., Lu, Y., & Brew, B. K.
Affiliations
  • Karolinska Institutet (SE)
  • Karolinska University Hospital (SE)
ORCID
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2019-04-07
Volume
53
Issue
5
Pages
1802142
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/13993003.02142-2018
OpenAlex
W2914506604
Cited by
48
References
7
Citations by year
2026: 4 · 2025: 4 · 2024: 9 · 2023: 2 · 2022: 11 · 2021: 5 · 2020: 10 · 2019: 3
FWCI
4.97
Type
journal article
Language
en
Open access
Licence
www.ersjournals.com/user-licence (vor)
Locations
  • European Respiratory Journal (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Funders
  • Hjärt-Lungfonden
  • Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2013-2292, 2015-00289)
  • Swedish Asthma and Allergy Associations' Research Foundation
  • Vetenskapsrådet (2013-8689, 2017-00641, 340-2013-5867)
  • Stockholms Läns Landsting
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
asthma, emotional characteristics, depression, anxiety, neuroticism, genetic correlation, polygenic risk score, shared genetic risk, Swedish Twin Registry
MeSH terms
Neuroticism, Adult, Aged, Anxiety, Asthma, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Middle Aged, Sweden, Cohort Studies, Comorbidity, Logistic Models, Genetic Predisposition to Disease, Multifactorial Inheritance, Genome-Wide Association Study

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