Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators
Open accessAbstract
Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.
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Anxiety and depression are present at all three stages of the experience of asthma: onset, progression, and exacerbation.
“They propose that anxiety and depression are present at all three stages of the experience of asthma: onset, progression, and exacerbation.14”
From A systematic review of psychological, physical health factors, and quality of life in adult asthma (2019) · cites this paper as [14]
The European Asthma Research and Innovation Partnership has identified understanding the role of psychological factors as an unmet need in improving asthma outcomes.
“Indeed, the European Asthma Research and Innovation Partnership has identified understanding the role of psychological factors as an unmet need in improving asthma outcomes.14,15”
From A systematic review of psychological, physical health factors, and quality of life in adult asthma (2019) · cites this paper as [14]
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References 493 · Cited by 55
Part of this paper’s reference list could not be split into single entries.
Research works printed but not linked: 2
- Masefield SCea. Driving Investment in Asthma Research in Europe: Priorities to Prevent, Cure and Manage Asthma More Effectively. Am J Respir Crit Care Med 2016; 193: A2668.
- Martinez FD, Vercelli D. Asthma. Lancet 2013; 382: 1360-1372.
- Authors
- Edwards, M. R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J. A., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M. G., Chung, K. F., Cookson, W., Cullinan, P., Hawrylowicz, C., Lommatzsch, M., Jackson, D., Lutter, R., Marsland, B., Moffatt, M., Thomas, M., Virchow, J. C., Xanthou, G., Edwards, J., Walker, S., & Johnston, S. L.
- Affiliations
- Imperial College London (GB)
- Philipps University of Marburg (DE)
- University of Southampton (GB)
- Academy of Athens (GR)
- King's College London (GB)
- University of Rostock (DE)
- Centre Hospitalier Universitaire Vaudois (CH)
- Asthma UK (GB)
- ORCID
- Edwards, Michael R.
- Saglani, Sejal
- Skevaki, Chrysanthi
- Ainsworth, Ben
- Andreakos, Evangelos
- Belvisi, Maria G.
- Chung, Kian Fan
- Cookson, William
- Cullinan, Paul
- Hawrylowicz, Catherine
- Lommatzsch, Marek
- Jackson, David
- Marsland, Benjamin
- Moffatt, Miriam
- Thomas, Mike
- Xanthou, Georgina
- Edwards, Jessica
- Walker, Samantha
- Johnston, Sebastian L.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2017-05
- Volume
- 49
- Issue
- 5
- Pages
- 1602448
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2611301804
- Cited by
- 55
- References
- 493
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 9
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Pure Amsterdam UMC (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- IRIS (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Pure (University of Bath) (submittedVersion, other-oa)
- SERVAL (Université de Lausanne) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Seventh Framework Programme (602077)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- asthma, asthma mechanisms, unmet clinical needs, asthma phenotypes, asthma exacerbations, disease severity, disease-modifying therapy, asthma prevention
- MeSH terms
- Asthma, Consensus Statements as Topic, Europe, Humans, Disease Progression, Needs Assessment, Biomedical Research
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