The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways
Open accessAbstract
Background: Quorum sensing is a process of bacterial cell-to-cell communication involving the production and detection of extracellular signaling molecules called autoinducers. Recently, it has been proposed that autoinducer-2 (AI-2), a furanosyl borate diester derived from the recycling of S-adenosyl-homocysteine (SAH) to homocysteine, serves as a universal signal for interspecies communication. Results: In this study, 138 completed genomes were examined for the genes involved in the synthesis and detection of AI-2. Except for some symbionts and parasites, all organisms have a pathway to recycle SAH, either using a two-step enzymatic conversion by the Pfs and LuxS enzymes or a one-step conversion using SAH-hydrolase (SahH). 51 organisms including most Gamma-, Beta-, and Epsilonproteobacteria, and Firmicutes possess the Pfs-LuxS pathway, while Archaea, Eukarya, Alphaproteobacteria, Actinobacteria and Cyanobacteria prefer the SahH pathway. In all 138 organisms, only the three Vibrio strains had strong, bidirectional matches to the periplasmic AI-2 binding protein LuxP and the central signal relay protein LuxU. The initial two-component sensor kinase protein LuxQ, and the terminal response regulator luxO are found in most Proteobacteria, as well as in some Firmicutes, often in several copies. Conclusions: The genomic analysis indicates that the LuxS enzyme required for AI-2 synthesis is widespread in bacteria, while the periplasmic binding protein LuxP is only present in Vibrio strains. Thus, other organisms may either use components different from the AI-2 signal transduction system of Vibrio strains to sense the signal of AI-2, or they do not have such a quorum sensing system at all.
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Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
(1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,715
Fuqua, W. C., Winans, S. C., & Greenberg, E. P. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.269-275.1994 · Cited by 2,927
Quorum-sensing in Gram-negative bacteria
Whitehead, N. (2001) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(01)00059-6 · Cited by 1,607
Structural identification of a bacterial quorum-sensing signal containing boron
Chen, X., Schauder, S., Potier, N., Van Dorsselaer, A., Pelczer, I., Bassler, B. L., & Hughson, F. M. (2002) · Nature · doi:10.1038/415545a · Cited by 1,571
Kanehisa, M. (2002) · Novartis Foundation Symposia · doi:10.1002/0470857897.ch8 · Cited by 1,383
Surette, M. G., Miller, M. B., & Bassler, B. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1639 · Cited by 976
Lenz, D. H., Mok, K. C., Lilley, B. N., Kulkarni, R. V., Wingreen, N. S., & Bassler, B. L. (2004) · Cell · doi:10.1016/j.cell.2004.06.009 · Cited by 971
Schell, M. A., Karmirantzou, M., Snel, B., Vilanova, D., Berger, B., Pessi, G., Zwahlen, M.-C., Desiere, F., Bork, P., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 948
Bacteria–host communication: the language of hormones
Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P., & Kaper, J. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537100100 · Cited by 902
Quorum-sensing regulators control virulence gene expression in Vibrio cholerae
Zhu, J., Miller, M. B., Vance, R. E., Dziejman, M., Bassler, B. L., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052694299 · Cited by 849
Cited by
Members of the human gut microbiota involved in recovery from Vibrio cholerae infection
Hsiao, A., Ahmed, A. M. S., Subramanian, S., Griffin, N. W., Drewry, L. L., Petri, W. A., Haque, R., Ahmed, T., & Gordon, J. I. (2014) · Nature · doi:10.1038/nature13738 · Cited by 387
Diffusible signals and interspecies communication in bacteria
Ryan, R. P., & Dow, J. M. (2008) · Microbiology · doi:10.1099/mic.0.2008/017871-0 · Cited by 284
Microbial interactions in building of communities
Wright, C. J., Burns, L. H., Jack, A. A., Back, C. R., Dutton, L. C., Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2013) · Molecular Oral Microbiology · doi:10.1111/omi.12012 · Cited by 185
Dixon, E. F., & Hall, R. A. (2015) · Cellular Microbiology · doi:10.1111/cmi.12490 · Cited by 73
Hongsthong, A., Sirijuntarut, M., Prommeenate, P., Lertladaluck, K., Porkaew, K., Cheevadhanarak, S., & Tanticharoen, M. (2008) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2008.01330.x · Cited by 47
Metadata
- Authors
- Sun, J., Daniel, R., Wagner-Döbler, I., & Zeng, A.-P.
- Venue
- BMC Evolutionary Biology
- Published
- 2004-09-29
- Volume
- 4
- Issue
- 1
- Pages
- 36-36
- ISSN
- 1471-2148 (ISSN-L)
- OpenAlex
- W1548495754
- Cited by
- 278
- References
- 39
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sun, J., Daniel, R., Wagner-Döbler, I., & Zeng, A.-P. (2004). Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways. BMC Evolutionary Biology. https://doi.org/10.1186/1471-2148-4-36
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