The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury
Open accessAbstract
BACKGROUND: The active form of vitamin D (1,25(OH)2D3) has been shown to inhibit development of inflammatory bowel disease (IBD) in IL-10 KO mice. Here, the role of the vitamin D receptor (VDR) and 1,25(OH)2D3 in acute experimental IBD was probed. RESULTS: VDR KO mice were extremely sensitive to dextran sodium sulfate (DSS) and there was increased mortality of the VDR KO mice at doses of DSS that only caused a mild form of colitis in wildtype (WT) mice. DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC. DSS concentrations as low as 0.5% were enough to induce bleeding, ulceration and weight loss in VDR KO mice. VDR KO mice failed to recover following the removal of DSS, while WT mice showed signs of recovery within 5 days of DSS removal. The early mortality of DSS treated VDR KO mice was likely due to perforation of the bowel and resulting endotoxemia. VDR KO mice were hyper-responsive to exogenously injected LPS and cultures of the peritoneal exudates of moribund DSS treated VDR KO mice were positive for bacterial growth. 1,25(OH)2D3 in the diet or rectally decreased the severity and extent of DSS-induced inflammation in WT mice. CONCLUSION: The data point to a critical role for the VDR and 1,25(OH)2D3 in control of innate immunity and the response of the colon to chemical injury.
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Cited by
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
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Epidemiology and risk factors for IBD
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Vitamin D: modulator of the immune system
Baeke, F., Takiishi, T., Korf, H., Gysemans, C., & Mathieu, C. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.001 · Cited by 1,300
Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier
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Metadata
- Authors
- Froicu, M., & Cantorna, M. T.
- Venue
- BMC Immunology
- Published
- 2007
- Volume
- 8
- Issue
- 1
- Pages
- 5
- ISSN
- 1471-2172 (ISSN-L)
- OpenAlex
- W2086086320
- Cited by
- 273
- References
- 42
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- gold
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