Portal vein thrombosis; risk factors, clinical presentation and treatment
Open accessAbstract
BACKGROUND: Portal vein thrombosis (PVT) is increasingly frequently being diagnosed, but systematic descriptions of the natural history and clinical handling of the condition are sparse. The aim of this retrospective study was to describe risk factors, clinical presentation, complications and treatment of portal vein thrombosis in a single-centre. METHODS: Sixty-seven patients were identified in the electronic records from 1992 to 2005. All data were obtained from the patient records. RESULTS: One or more risk factors (e.g. prothrombotic disorder or abdominal inflammation) were present in 87%. Symptoms were abdominalia, splenomegaly, fever, ascites, haematemesis, and weight loss. Abdominalia and fever occurred more frequently in patients with acute PVT. Frequent complications were splenomegaly, oesophageal- and gastric varices with or without bleeding, portal hypertensive gastropathy and ascites. Varices and bleeding were more frequent in patients with chronic PVT. Patients who received anticoagulant therapy more frequently achieved partial/complete recanalization. Patients with varices who were treated endoscopically in combination with beta-blockade had regression of the varices. The overall mortality was 13% in one year, and was dependent on underlying causes. CONCLUSION: Most patients had a combination of local and systemic risk factors for PVT. We observed that partial/complete recanalization was more frequent in patients treated with anticoagulation therapy, and that regression of varices was more pronounced in patients who where treated with active endoscopy combined with pharmacological treatment.
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Severe cases of COVID-19 were also reported, requiring emergency surgery for acute bowel ischemia or perforation.
“However, severe cases were also reported, requiring emergency surgery for acute bowel ischemia or perforation [5,8].”
From Acute mesenteric ischemia in COVID-19 patients (2021) · cites this paper as [5]
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References 28 · Cited by 217
- Authors
- Sogaard, K. K., Astrup, L. B., Vilstrup, H., & Gronbaek, H.
- Affiliations
- Aarhus University Hospital (DK)
- ORCID
- Vilstrup, Hendrik
- Venue
- BMC Gastroenterology
- Published
- 2007-08-15
- Volume
- 7
- Issue
- 1
- Pages
- 34-34
- ISSN
- 1471-230X (ISSN-L)
- PMC
- PMC1976099
- OpenAlex
- W2028878842
- Cited by
- 217
- References
- 28
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 16 · 2021: 7 · 2020: 14 · 2019: 17 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 15 · 2012: 8
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Gastroenterology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- portal vein thrombosis, risk factors, prothrombotic disorders, abdominal inflammation, clinical features, complications, variceal bleeding, portal hypertensive gastropathy, ascites, splenomegaly, anticoagulation, recanalization, endoscopic variceal treatment, beta-adrenergic blockade, mortality
- MeSH terms
- Adolescent, Adult, Aged, Anticoagulants, Ascites, Cause of Death, Female, Fever, Gastrointestinal Hemorrhage, Humans, Liver Cirrhosis, Male, Middle Aged, Neoplasms, Portal Vein, Radiography, Retrospective Studies, Risk Factors, Splenomegaly, Ultrasonography, Varicose Veins, Comorbidity, Causality, Survival Rate, Venous Thrombosis
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