The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Risk factors and outcomes associated with acute kidney injury following ruptured abdominal aortic aneurysm
Open accessAbstract
Background: Current data describing the epidemiology of acute kidney injury (AKI) following repair of ruptured abdominal aortic aneurysm (rAAA) are limited and long-term outcomes are largely unknown. Our objectives were to describe the incidence rate, risk factors, clinical course and long-term outcomes of AKI following rAAA repair. Methods: Retrospective population-based cohort study of all referrals undergoing emergency repair of rAAA in Northern Alberta from January 1, 2002 to December 31 2009. Demographic, clinical, physiologic and laboratory data were extracted. AKI was defined and classified according to the AKIN criteria. Results: In total, 140 patients survived to receive emergent rAAA repair. Post-operative AKI occurred in 75.7% of patients (n = 106), 78.3% (n = 83) of which occurred during the initial 24 hours of ICU admission. AKIN stage 1, 2, and 3 occurred in 47 (33.6%), 36 (25.7%) and 23 (16.4%), respectively, with 19 patients receiving renal replacement therapy (RRT). Several clinical and biochemical patient factors were associated with incident AKI, including baseline estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 (odds ratio [OR] 2.94; 95% CI, 1.15-7.51, p = 0.03), need for mechanical ventilation (OR 22.7; 95% CI, 7.0-72.1, p < 0.0001) and vasoactive therapy (OR 9.9; 95% CI, 3.0-32.2, p < 0.0001) and higher mean APACHE II scores (25.7 [8.2] vs. 16.3 [4.9], p < 0.0001). AKI was associated with a higher ICU (28.3% vs. 0%; p = 0.0008) and in-hospital case-fatality rate (35.9% vs. 0%, p = 0.0001). Of 102 survivors to discharge, 65.7% (n = 67) recovered to baseline kidney function. In multivariable analysis, greater severity of AKI (OR 5.01; 95% CI, 2.34-10.7, p < 0.001) and lower baseline eGFR (OR 0.96; 95% CI, 0.93-0.99, p = 0.03) were associated with non-recovery. AKI remained independently associated with 1-year mortality after adjusting for age, sex, comorbidity, and illness severity (OR 5.21; 95% CI, 1.04-26.2, p = 0.045; AUC 0.83; H-L GoF, p = 0.26). Among survivors at 1-year, only 63.4% (n = 55) had complete kidney recovery. Conclusions: Following rAAA repair, AKI is a common complication independently associated with long-term post-operative mortality. A significant proportion of AKI sufferers in this setting fail to recover to baseline kidney function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040296 · Cited by 23,020
Flagged first, then by citations
Research works printed but not linked: 30
- Bengtsson H, Bergqvist D: Ruptured abdominal aortic aneurysm: a population-based study. J Vasc Surg. 1993, 18 (1): 74-80. · DOI
- Gillum RF: Epidemiology of aortic aneurysm in the United States. J Clin Epidemiol. 1995, 48 (11): 1289-1298. · DOI
- McPhee J, Eslami MH, Arous EJ, Messina LM, Schanzer A: Endovascular treatment of ruptured abdominal aortic aneurysms in the United States (2001–2006): a significant survival benefit over open repair is independently associated with increased institutional volume. J Vasc Surg. 2009, 49 (4): 817-826. · DOI
- Hoornweg LL, Storm-Versloot MN, Ubbink DT, Koelemay MJ, Legemate DA, Balm R: Meta analysis on mortality of ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2008, 35 (5): 558-570. · DOI
- Botha JA, Tiruvoipati R, Last GC, Somjen G, Chue WL: Predictors of outcome of ruptured aortic aneurysms in a metropolitan hospital. Anaesth Intensive Care. 2008, 36 (4): 560-564. · DOI
- Djavani K, Wanhainen A, Valtysson J, Bjorck M: Colonic ischaemia and intra-abdominal hypertension following open repair of ruptured abdominal aortic aneurysm. Br J Surg. 2009, 96 (6): 621-627. · DOI
- Ellenberger C, Schweizer A, Diaper J, Kalangos A, Murith N, Katchatourian G, Panos A, Licker M: Incidence, risk factors and prognosis of changes in serum creatinine early after aortic abdominal surgery. Intensive Care Med. 2006, 32 (11): 1808-1816. · DOI
- Tallgren M, Niemi T, Poyhia R, Raininko E, Railo M, Salmenpera M, Lepantalo M, Hynninen M: Acute renal injury and dysfunction following elective abdominal aortic surgery. Eur J Vasc Endovasc Surg. 2007, 33 (5): 550-555. · DOI
- West CA, Noel AA, Bower TC, Cherry KJ, Gloviczki P, Sullivan TM, Kalra M, Hoskin TL, Harrington JR: Factors affecting outcomes of open surgical repair of pararenal aortic aneurysms: a 10-year experience. J Vasc Surg. 2006, 43 (5): 921-927. discussion 27–8 · DOI
- Davies RS, Dawlatly S, Clarkson JR, Bradbury AW, Adam DJ: Outcome in patients requiring renal replacement therapy after open surgical repair for ruptured abdominal aortic aneurysm. Vasc Endovascular Surg. 2010, 44 (3): 170-173. · DOI
- Frikha M, Montravers P, Vogel J, Enriquez I, Nimier M, Dureuil B, Desmonts JM: Severity scores underestimate the seriousness of acute renal failure after emergency surgery. Ann Fr Anesth Reanim. 1995, 14 (6): 478-483. · DOI
- Barratt J, Parajasingam R, Sayers RD, Feehally J: Outcome of acute renal failure following surgical repair of ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2000, 20 (2): 163-168. · DOI
- Berisa F, Beaman M, Adu D, McGonigle RJ, Michael J, Downing R, Fielding JW, Dunn J: Prognostic factors in acute renal failure following aortic aneurysm surgery. Q J Med. 1990, 76 (279): 689-698.
- Braams R, Vossen V, Lisman BA, Eikelboom BC: Outcome in patients requiring renal replacement therapy after surgery for ruptured and non-ruptured aneurysm of the abdominal aorta. Eur J Vasc Endovasc Surg. 1999, 18 (4): 323-327. · DOI
- Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE: The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int. 2011, 79 (12): 1361-1369. · DOI
- Ng KP, Chanouzas D, Fallouh B, Baharani J: Short and long-term outcome of patients with severe acute kidney injury requiring renal replacement therapy. QJM. 2012, 105 (1): 33-39. · DOI
- Wald R, Quinn RR, Adhikari NK, Burns KE, Friedrich JO, Garg AX, Harel Z, Hladunewich MA, Luo J, Mamdani M, Perl J, Ray JG: Risk of chronic dialysis and death following acute kidney injury. Am J Med. 2012, 125 (6): 585-593. · DOI
- de Souza IA, Karvellas CJ, Gibney RN, Bagshaw SM: Impact of intensive care unit admission during morning bedside rounds and mortality: a multi-center retrospective cohort study. Crit Care. 2012, 16 (3): R72- · DOI
- Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med. 1985, 13 (10): 818-829. · DOI
- Venge P, Lindahl B, Wallentin L: New generation cardiac troponin I assay for the access immunoassay system. Clin Chem. 2001, 47 (5): 959-961. · DOI
- Levey AS, Stevens LA, Schmid CH, Zhang YL, 3rd Castro AF, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J: A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009, 150 (9): 604-612. · DOI · Paper page
- Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007, 11 (2): R31- · DOI
- Wittenstein GJ: Complications of aortic aneurysm surgery: prevention and treatment. Thorac Cardiovasc Surg. 1987, 35 (Spec No 2): 136-139. · DOI
- Ricci Z, Ronco C, D’Amico G, De Felice R, Rossi S, Bolgan I, Bonello M, Zamperetti N, Petras D, Salvatori G, Dan M, Piccinni P: Practice patterns in the management of acute renal failure in the critically ill patient: an international survey. Nephrol Dial Transplant. 2006, 21 (3): 690-696. · DOI
- Macedo E, Castro I, Yu L, Abdulkader RR, Vieira JM: Impact of mild acute kidney injury (AKI) on outcome after open repair of aortic aneurysms. Ren Fail. 2008, 30 (3): 287-296. · DOI
- Coca SG, Singanamala S, Parikh CR: Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int. 2012, 81 (5): 442-448. · DOI
- James MT, Ghali WA, Tonelli M, Faris P, Knudtson ML, Pannu N, Klarenbach SW, Manns BJ, Hemmelgarn BR: Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function. Kidney Int. 2010, 78 (8): 803-809. · DOI
- van Kuijk JP, Flu WJ, Chonchol M, Hoeks SE, Winkel TA, Verhagen HJ, Bax JJ, Poldermans D: Temporary perioperative decline of renal function is an independent predictor for chronic kidney disease. Clin J Am Soc Nephrol. 2010, 5 (7): 1198-1204. · DOI
- Brown JR, Kramer RS, Coca SG, Parikh CR: Duration of acute kidney injury impacts long-term survival after cardiac surgery. Ann Thorac Surg. 2010, 90 (4): 1142-1148. · DOI
- Coca SG, King JT, Rosenthal RA, Perkal MF, Parikh CR: The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans. Kidney Int. 2010, 78 (9): 926-933. · DOI
Metadata
- Authors
- Kopolovic, I., Simmonds, K., Duggan, S., Ewanchuk, M., Stollery, D. E., & Bagshaw, S. M.
- Affiliations
- University of Alberta (CA)
- Alberta Health Services (CA)
- Corresponding author
- Bagshaw, Sean M
- ORCID
- Bagshaw, Sean M
- Venue
- BMC Nephrology
- Published
- 2013-05-01
- Volume
- 14
- Issue
- 1
- Pages
- 99-99
- ISSN
- 1471-2369 (ISSN-L)
- PMC
- PMC3651711
- OpenAlex
- W2153221426
- Cited by
- 32
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Nephrology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Alberta Innovates
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Surgery › Aortic aneurysm repair treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
- Keywords
- acute kidney injury, ruptured abdominal aortic aneurysm, risk factors, AKIN criteria, renal replacement therapy, estimated glomerular filtration rate, mechanical ventilation, vasoactive therapy, APACHE II score, case fatality, long-term renal outcomes, postoperative complications, AKI incidence, northern Alberta, Canada
- MeSH terms
- Aged, Aged, 80 and over, Aortic Rupture, Female, Humans, Male, Middle Aged, Population Surveillance, Retrospective Studies, Risk Factors, Cohort Studies, Treatment Outcome, Aortic Aneurysm, Abdominal, Acute Kidney Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
