Behavioural change in relation to alcohol exposure in early pregnancy and impact on perinatal outcomes - a prospective cohort study
Open accessAbstract
BACKGROUND: There has been limited research addressing whether behavioural change in relation to alcohol exposure in pregnancy results in better perinatal outcomes. METHODS: A cohort study of 6725 women who booked for antenatal care and delivered in a large urban teaching hospital in 2010-2011. A detailed history of alcohol consumption pre-pregnancy and during early pregnancy was recorded at the first antenatal visit with follow-up of the mother and infant until discharge following birth. Adverse perinatal outcomes were compared for 'non-drinkers', 'ex-drinkers' and 'current drinkers'. RESULTS: Of the 6017 (90%) women who reported alcohol consumption prior to pregnancy 3325 (55%) engaged in binge drinking and 266 (4.4%) consumed more than 14 units on average per week. At the time of booking 5649 (94%) women were ex-drinkers and of the 368 women who continued to drink 338 (92%) had a low intake (0-5 units per week), 30 (8%) an excess intake (6-20+ units per week) and 93 (25%) reported at least one episode of binge drinking. Factors associated with continuing to drink in early pregnancy included older maternal age (30-39 years), (OR 1.6; 95% CI 1.3 to 1.8), Irish nationality (OR 3.1; 95% CI 2.2 to 4.3) and smoking (OR 2.6; 95% CI 1.9 to 3.5). Ex-drinkers had similar perinatal outcomes to non-drinkers. Compared to non-drinkers current drinking was associated with an increased risk of intrauterine growth restriction (IUGR) (13% versus 19%, crude OR 1.6; 95% CI 1.1 to 2.2, adjusted OR 1.2; 95% CI 0.8 to 1.8). The greatest risk of IUGR was among women who continued to both drink and smoke, (9% versus 32%, crude OR 4.8; 95% CI 3.3 to 7.0, adjusted OR 4.5; 95% CI 3.1 to 6.7). CONCLUSIONS: Public Health campaigns need to emphasise the potential health gains of abstaining from both alcohol and smoking in pregnancy.
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Tobacco- and alcohol consumption are two of the most critical teratogens for prenatal development.
“Tobacco- and alcohol consumption are two of the most critical teratogens for prenatal development [10, 11].”
From Associations between periconceptional lifestyle behaviours and adverse pregnancy outcomes (2021) · cites this paper as [10]
The Results (Sub-group analyses of women who drink and smoke; page not provided) report substantially higher intrauterine growth restriction among women who both drank and smoked during pregnancy. This supports a risk to fetal growth, but the paper does not identify tobacco and alcohol as two of the most critical teratogens or compare their importance with other prenatal exposures. (LLM, conf=0.85)
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Lobel, M., & Dunkel Schetter, C. (2016) · Encyclopedia of Mental Health · doi:10.1016/b978-0-12-397045-9.00164-6 · Cited by 61 · see citing works
Associations between periconceptional lifestyle behaviours and adverse pregnancy outcomes
Maas, V. Y. F., Poels, M., Lamain-de Ruiter, M., Kwee, A., Bekker, M. N., Franx, A., & Koster, M. P. H. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-03935-x · Cited by 43 · see citing works
- Authors
- Murphy, D. J., Mullally, A., Cleary, B. J., Fahey, T., & Barry, J.
- Affiliations
- Trinity College Dublin (IE)
- Royal College of Surgeons in Ireland (IE)
- Corresponding author
- Murphy, Deirdre J
- Venue
- BMC Pregnancy and Childbirth
- Published
- 2013-01-16
- Volume
- 13
- Issue
- 1
- Pages
- 8-8
- ISSN
- 1471-2393 (ISSN-L)
- PMC
- PMC3549282
- OpenAlex
- W2132473521
- Cited by
- 32
- References
- 1
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 1
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Pregnancy and Childbirth (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by-nc-nd)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- alcohol consumption in pregnancy, binge drinking, perinatal outcomes, fetal growth restriction, maternal smoking, ex-drinkers, maternal age, behavior change
- MeSH terms
- Adolescent, Adult, Alcohol Drinking, Female, Fetal Growth Retardation, Humans, Infant, Infant, Newborn, Pregnancy, Risk Factors, Smoking, Cohort Studies, Health Behavior, Logistic Models
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