The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study
Open accessAbstract
BACKGROUND: A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects. METHODS: In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals. RESULTS: ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation. CONCLUSIONS: Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
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Metadata
- Authors
- Cherrier, M. M., Borghesani, P. R., Shelton, A. L., & Higano, C. S.
- Venue
- BMC Cancer
- Published
- 2010-01-04
- Volume
- 10
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1471-2407 (ISSN-L)
- OpenAlex
- W2086650050
- Cited by
- 395
- References
- 46
- FWCI
- 17.22
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
