White matter abnormalities in adolescents with generalized anxiety disorder: a diffusion tensor imaging study
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BACKGROUND: Previous neuroimaging studies have suggested an abnormal neural circuitry of emotion regulation including the amygdala and prefrontal cortex in both adult and adolescent generalized anxiety disorder (GAD) patients. Aberrant integrity of white matter in this neural circuitry has been verified in adult GAD patients. White matter abnormalities in adolescent GAD patients have not been detected. METHODS: Twenty-five adolescents with GAD and 24 healthy controls underwent a diffusion tensor imaging scan. Fractional anisotropy (FA) was compared between groups with a voxel-wise Tract-Based Spatial Statistics (TBSS) analysis method. RESULTS: Compared with healthy controls, adolescents with GAD showed significantly reduced FA in bilateral uncinate fasciculus, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and corona radiata. CONCLUSIONS: The findings in the present study suggest a neural basis of emotion dysregulation in adolescent GAD patients.
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There is some evidence of similar structural abnormalities in ventral portions of the prefrontal cortex and the uncinate fasciculus for anxious youth.
“While the number of studies examining structural changes in anxious vs. non-anxious adolescents is low, there is some evidence of similar structural abnormalities in ventral portions of the prefrontal cortex and the uncinate fasciculus for anxious youth29–34.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [32]
Weaker structural integrity of the uncinate fasciculus has been found in populations with anxious temperament, suggesting that this tract may play a crucial role in anxiety aetiology.
“Notably, weaker structural integrity of the uncinate fasciculus has been found in populations with anxious temperament24–27,32, suggesting that this tract may play a crucial role in anxiety aetiology.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [32]
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References 43 · Cited by 87
- Authors
- Liao, M., Yang, F., Zhang, Y., He, Z., Su, L., & Li, L.
- Affiliations
- Second Xiangya Hospital of Central South University (CN)
- Corresponding author
- Su, Linyan
- Li, Lingjiang
- Venue
- BMC Psychiatry
- Published
- 2014-02-15
- Volume
- 14
- Issue
- 1
- Pages
- 41-41
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC3937009
- OpenAlex
- W2129344602
- Cited by
- 87
- References
- 43
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 3
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (973 Program, 30830046, 81171286, 91232714, 81171291, 81101004)
- National Key Research and Development Program of China (2009CB918303)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- generalized anxiety disorder, adolescents, white matter abnormalities, fractional anisotropy, uncinate fasciculus, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, corona radiata, emotion regulation, neural circuits
- MeSH terms
- Adolescent, Anxiety Disorders, Brain, Emotions, Female, Humans, Image Processing, Computer-Assisted, Male, Nerve Fibers, Myelinated, Nerve Net, Anisotropy, Diffusion Tensor Imaging, Neuroimaging
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