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Cited by 154Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisHIV, TB, and STIs Epidemiology

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Treatment outcome of tuberculosis patients at Gondar University Teaching Hospital, Northwest Ethiopia. A five - year retrospective study

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Tessema, Belay, Muche, Abebe, Bekele, Assegedech, Reissig, Dieter, Emmrich, Frank, Sack, Ulrich·2009·BMC Public Health
DOI 10.1186/1471-2458-9-371PMC PMC2765962
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Abstract

BACKGROUND: In Gondar University Teaching Hospital standardized tuberculosis prevention and control programme, incorporating Directly Observed Treatment, Short Course (DOTS) started in 2000. According to the proposal of World Health Organization (WHO), treatment outcome is an important indicator of tuberculosis control programs. This study investigated the outcome of tuberculosis treatment at Gondar University Teaching Hospital in Northwest Ethiopia. METHODS: We analyzed the records of 4000 tuberculosis patients registered at Gondar University Teaching Hospital from September 2003 to May 2008. Treatment outcome and tuberculosis type were categorized according to the national tuberculosis control program guideline. Multivariate analysis using logistic regression model was used to analyse the association between treatment outcome and potential predictor variables. RESULTS: From the total of 4000 patients, tuberculosis type was categorized as extrapulmonary in 1133 (28.3%), smear negative pulmonary tuberculosis in 2196 (54.9%) and smear positive pulmonary tuberculosis in 671 (16.8%) cases. Of all patients, treatment outcome was classified as successfully treated in 1181(29.5%), defaulted in 730 (18.3%), died in 403 (10.1%), treatment failed in six (0.2%) and transferred out in 1680 (42.0%) patients. Males had the trend to be more likely to experience death or default than females, and the elderly were more likely to die than younger. The proportion of default rate was increased across the years from 97(9.2%) to 228(42.9%). Being female, age group 15-24 years, smear positive pulmonary tuberculosis and being urban resident were associated with higher treatment success rate. CONCLUSION: The treatment success rate of tuberculosis patients was unsatisfactorily low (29.5%). A high proportion of patients died (10.1%) or defaulted (18.3%), which is a serious public health concern that needs to be addressed urgently.

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Metadata

Authors
Tessema, B., Muche, A., Bekele, A., Reissig, D., Emmrich, F., & Sack, U.
Affiliations
  • University of Gondar (ET)
  • Leipzig University (DE)
  • Fraunhofer Institute for Cell Therapy and Immunology (DE)
Corresponding author
Tessema, Belay
ORCID
Venue
BMC Public Health
Publisher
Springer Science and Business Media LLC
Published
2009-10-04
Volume
9
Issue
1
Pages
371-371
ISSN
1471-2458 (ISSN-L)
DOI
10.1186/1471-2458-9-371
PMC
PMC2765962
OpenAlex
W2059980350
Cited by
154
References
32
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 15 · 2018: 26 · 2017: 10 · 2016: 22 · 2015: 13 · 2014: 16 · 2013: 13 · 2012: 3
FWCI
1.60
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion, other-oa)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV, TB, and STIs Epidemiology
Keywords
tuberculosis, treatment outcomes, DOTS, treatment default, tuberculosis mortality, smear-negative tuberculosis, extrapulmonary tuberculosis, sex differences, age differences, urban residence, predictors of treatment success
MeSH terms
Adolescent, Adult, Aged, Antitubercular Agents, Child, Child, Preschool, Ethiopia, Hospitals, Teaching, Humans, Infant, Middle Aged, Patient Compliance, Retrospective Studies, Tuberculosis, Treatment Outcome, Treatment Failure, Young Adult

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