Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma
Open accessAbstract
Background: Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. Methods: In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients. Results: In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity. Conclusion: Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.
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Renal cell carcinoma exhibits frequent overexpression of MDR1.
“which exhibits frequent overexpression of MDR1 (55).”
From The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells (2022) · cites this paper as [55]
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References 35 · Cited by 88
- Authors
- Walsh, N., Larkin, A., Kennedy, S., Connolly, L., Ballot, J., Ooi, W., Gullo, G., Crown, J., Clynes, M., & O'Driscoll, L.
- Affiliations
- Dublin City University (IE)
- St. Vincent's University Hospital (IE)
- Corresponding author
- Larkin, Annemarie
- Venue
- BMC Urology
- Published
- 2009-06-24
- Volume
- 9
- Issue
- 1
- Pages
- 6-6
- ISSN
- 1471-2490 (ISSN-L)
- PMC
- PMC2723136
- OpenAlex
- W2125905978
- Cited by
- 88
- References
- 35
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 8 · 2012: 5
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Urology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dublin City University Open Access Institutional Repository (Dublin City University) (submittedVersion, cc-by-nc-sa)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion, cc-by)
- Funders
- Dublin City University
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- renal cell carcinoma, multidrug resistance, P-glycoprotein, MRP1, ABC transporters, chemoresistance, efflux pumps, protein expression
- MeSH terms
- Aged, Aged, 80 and over, Antineoplastic Agents, Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Male, Middle Aged, Neoplasm Proteins, Tumor Cells, Cultured, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Multidrug Resistance-Associated Proteins, ATP-Binding Cassette, Sub-Family C Proteins
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