Prevention of post-surgical abdominal adhesions by a novel biodegradable thermosensitive PECE hydrogel.
Open accessAbstract
Background: Post-operative peritoneal adhesions are common and serious complications for modern medicine. We aim to prevent post-surgical adhesions using biodegradable and thermosensitive poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) hydrogel. In this work, we investigated the effect of PECE hydrogel on preventing post-surgical abdominal adhesions in mouse and rat models. Results: The PECE hydrogel in sol state could be transformed into gel in less than 20 s at 37°C. In addition, the PECE hydrogel could be easily adhered to the damaged peritoneal surfaces, and be gradually degraded and absorbed by the body within 14 days along with the healing of peritoneal wounds. A notable efficacy of the PECE hydrogel in preventing peritoneal adhesions was demonstrated in the animal models. In contrast, all untreated animals developed adhesions requiring sharp dissection. Furthermore, no significant histopathological changes were observed in main organs of the hydrogel-treated animals. Conclusion: Our results suggested that the thermosensitive PECE hydrogel was an effective, safe, and convenient agent on preventing post-surgical intro-abdominal adhesions.
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PEG-based barriers effectively prevent fibrotic adhesion formation by creating a hydrated, non-fouling surface that inhibits cellular attachment and extracellular matrix deposition after surgery.
“PEG-based barriers effectively prevent fibrotic adhesion formation by creating a hydrated, non-fouling surface that inhibits cellular attachment and extracellular matrix deposition following surgical procedures [209,210].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [209]
The Discussion reports that the PECE hydrogel reduced postoperative peritoneal adhesions in animal models and describes its action as physically separating injured surfaces. It does not attribute this effect to a hydrated, non-fouling surface that inhibits cellular attachment or extracellular matrix deposition; the Discussion says the precise mechanism is not clearly understood. (LLM, conf=0.87)
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Sorted by citations
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Yang, B., Gong, C., Qian, Z., Zhao, X., Li, Z., Qi, X., Zhou, S., Zhong, Q., Luo, F., & Wei, Y.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Qian, ZhiYong
- Zhao, Xia
- ORCID
- Venue
- BMC Biotechnology
- Published
- 2010-09-09
- Volume
- 10
- Issue
- 1
- Pages
- 65-65
- ISSN
- 1472-6750 (ISSN-L)
- PMC
- PMC2945983
- OpenAlex
- W1971275856
- Cited by
- 40
- References
- 0
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (2007SGY019, 2007AA021902)
- Topics
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
- Keywords
- peritoneal adhesions, thermosensitive hydrogel, biodegradable hydrogels, adhesion prevention, hydrogel biocompatibility
- MeSH terms
- Abdomen, Tissue Adhesions, Animals, Biocompatible Materials, Cecum, Female, Mice, Inbred C57BL, Peritoneum, Polyesters, Polyethylene Glycols, Wound Healing, Rats, Wistar, Hydrogels, Mice, Rats
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