The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Clinical implications and utility of field cancerization
Open accessAbstract
Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially transform a cell, or a group of cells in a particular organ. The early genetic events might lead to clonal expansion of pre-neoplastic daughter cells in a particular tumor field. Subsequent genomic changes in some of these cells drive them towards the malignant phenotype. These transformed cells are diagnosed histopathologically as cancers owing to changes in cell morphology. Conceivably, a population of daughter cells with early genetic changes (without histopathology) remain in the organ, demonstrating the concept of field cancerization. With present technological advancement, including laser capture microdisection and high-throughput genomic technologies, carefully designed studies using appropriate control tissue will enable identification of important molecular signatures in these genetically transformed but histologically normal cells. Such tumor-specific biomarkers should have excellent clinical utility. This review examines the concept of field cancerization in several cancers and its possible utility in four areas of oncology; risk assessment, early cancer detection, monitoring of tumor progression and definition of tumor margins.
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Slaughter, D. P., Southwick, H. W., & Smejkal, W. (1953) · Cancer · doi:10.1002/1097-0142(195309)6:5<963::aid-cncr2820060515>3.0.co;2-q · Cited by 3,545
Cancer as an evolutionary and ecological process
Merlo, L. M. F., Pepper, J. W., Reid, B. J., & Maley, C. C. (2006) · Nature Reviews Cancer · doi:10.1038/nrc2013 · Cited by 1,699
Braakhuis, B. J. M., Tabor, M. P., Kummer, J. A., Leemans, C. R., & Brakenhoff, R. H. (2003) · PubMed · Cited by 1,208
Integrative molecular concept modeling of prostate cancer progression
Tomlins, S. A., Mehra, R., Rhodes, D. R., Cao, X., Wang, L., Dhanasekaran, S. M., Kalyana-Sundaram, S., Wei, J. T., Rubin, M. A., Pienta, K. J., et al. (2007) · Nature Genetics · doi:10.1038/ng1935 · Cited by 922
Yu, Y. P., Landsittel, D., Jing, L., Nelson, J., Ren, B., Liu, L., McDonald, C., Thomas, R., Dhir, R., Finkelstein, S., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.158 · Cited by 758
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
Maley, C. C., Galipeau, P. C., Finley, J. C., Wongsurawat, V. J., Li, X., Sanchez, C. A., Paulson, T. G., Blount, P. L., Risques, R.-A., Rabinovitch, P. S., et al. (2006) · Nature Genetics · doi:10.1038/ng1768 · Cited by 696
Frequent clones of p53-mutated keratinocytes in normal human skin
Jonason, A. S., Kunala, S., Price, G. J., Restifo, R. J., Spinelli, H. M., Persing, J. A., Leffell, D. J., Tarone, R. E., & Brash, D. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14025 · Cited by 685
Surveillance, Epidemiology, and End Results Program
National Cancer Institute (2020) · Definitions · doi:10.32388/5owtl5 · Cited by 626
Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas
Deng, G., Lu, Y., Zlotnikov, G., Thor, A. D., & Smith, H. S. (1996) · Science · doi:10.1126/science.274.5295.2057 · Cited by 582
MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer
Shen, L., Kondo, Y., Rosner, G. L., Xiao, L., Hernandez, N. S., Vilaythong, J., Houlihan, P. S., Krouse, R. S., Prasad, A. R., Einspahr, J. G., et al. (2005) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dji275 · Cited by 498
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Molecular aspects of skin ageing
Naylor, E. C., Watson, R. E. B., & Sherratt, M. J. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.04.011 · Cited by 567
Lochhead, P., Chan, A. T., Nishihara, R., Fuchs, C. S., Beck, A. H., Giovannucci, E., & Ogino, S. (2015) · Modern Pathology · doi:10.1038/modpathol.2014.81 · Cited by 206
Apalla, Z., Sotiriou, E., Chovarda, E., Lefaki, I., Devliotou-Panagiotidou, D., & Ioannides, D. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09492.x · Cited by 116
Metadata
- Authors
- Dakubo, G. D., Jakupciak, J. P., Birch-Machin, M. A., & Parr, R. L.
- Venue
- Cancer Cell International
- Published
- 2007
- Volume
- 7
- Issue
- 1
- Pages
- 2
- ISSN
- 1475-2867 (ISSN-L)
- OpenAlex
- W2111808908
- Cited by
- 294
- References
- 81
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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