Cited by 166Malaria Research and ControlTravel-related health issuesMosquito-borne diseases and control

The DOI matches its Crossref record; 135 of the 136 references it cites were found in a registry or an index.

Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature

Open access

Lacerda, Marcus VG, Mourão, Maria PG, Alexandre, Márcia AA, Siqueira, André M, Magalhães, Belisa ML, Martinez-Espinosa, Flor E, Santana Filho, Franklin S, Brasil, Patrícia, Ventura, Ana MRS, Tada, Mauro S, Couto, Vanja SCD, Silva, Antônio R, Silva, Rita SU, Alecrim, Maria GC·2012·Malaria Journal

DOI 10.1186/1475-2875-11-12PMC PMC3268102

Open this paper in CoChat — free account Open PDF

Abstract

The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the Plasmodium vivax infection. It is the most geographically widespread parasite causing human malaria, with around 2.85 billion people living under risk of infection. The Brazilian Amazon region reports more than 50% of the malaria cases in Latin America and since 1990 there is a marked predominance of this species, responsible for 85% of cases in 2009. However, only a few complicated cases of P. vivax have been reported from this region. A systematic review of the Brazilian indexed and non-indexed literature on complicated cases of vivax malaria was performed including published articles, masters' dissertations, doctoral theses and national congresses' abstracts. The following information was retrieved: patient characteristics (demographic, presence of co-morbidities and, whenever possible, associated genetic disorders); description of each major clinical manifestation. As a result, 27 articles, 28 abstracts from scientific events' annals and 13 theses/dissertations were found, only after 1987. Most of the reported information was described in small case series and case reports of patients from all the Amazonian states, and also in travellers from Brazilian non-endemic areas. The more relevant clinical complications were anaemia, thrombocytopaenia, jaundice and acute respiratory distress syndrome, present in all age groups, in addition to other more rare clinical pictures. Complications in pregnant women were also reported. Acute and chronic co-morbidities were frequent, however death was occasional. Clinical atypical cases of malaria are more frequent than published in the indexed literature, probably due to a publication bias. In the Brazilian Amazon (considered to be a low to moderate intensity area of transmission), clinical data are in accordance with the recent findings of severity described in diverse P. vivax endemic areas (especially anaemia in Southeast Asia), however in this region both children and adults are affected. Finally, gaps of knowledge and areas for future research are opportunely pointed out.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/1475-2875-11-12

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Natural history of chronic hepatitis C
Seeff, L. B. (2002) · Hepatology · doi:10.1053/jhep.2002.36806 · Cited by 1,550
Severe falciparum malaria
Satpathy, S. K., Mohanty, N., Nanda, P., & Samal, G. C. (2004) · The Indian Journal of Pediatrics · doi:10.1007/bf02723094 · Cited by 1,134
The neglected burden of Plasmodium vivax malaria
Mendis, K., Sina, B. J., Marchesini, P. B., & Carter, R. (2001) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2001.64.97 · Cited by 976
Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster.
(2000) · PubMed · Cited by 920
Vivax Malaria: Neglected and Not Benign
Price, R. N., Tjitra, E., Guerra, C. A., Yeung, S., White, N. J., & Anstey, N. M. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.79 · Cited by 840
Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite
Müeller, I., Galinski, M. R., Baird, J. K., Carlton, J. M., Kochar, D. K., Alonso, P. L., & Portillo, H. A. D. (2009) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(09)70177-x · Cited by 661
Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia
Tjitra, E., Anstey, N. M., Sugiarto, P., Warikar, N., Kenangalem, E., Karyana, M., Lampah, D. A., & Price, R. N. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050128 · Cited by 609
Malaria in Brazil: an overview
Oliveira-Ferreira, J., Lacerda, M., Brasil, P., Ladislau, J. L. D. B., Tauil, P. L., & Daniel‐Ribeiro, C. T. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-115 · Cited by 512
Self-citation
The International Limits and Population at Risk of Plasmodium vivax Transmission in 2009
Guerra, C. A., Howes, R. E., Patil, A. P., Gething, P. W., Boeckel, T. P. V., Temperley, W. H., Kabaria, C. W., Tatem, A. J., Manh, B. H., Elyazar, I., et al. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000774 · Cited by 468
Plasmodium vivax and Mixed Infections Are Associated with Severe Malaria in Children: A Prospective Cohort Study from Papua New Guinea
Genton, B., D’Acremont, V., Rare, L., Baea, K., Reeder, J. C., Alpers, M. P., & Müller, I. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050127 · Cited by 461

Show all 136 references

Research works printed but not linked: 50

WHO: World Malaria Report 2010. 2010
Chagas C: Hematological studies of impaludism. MD Thesis. 1903, Manguinhos Institute
Batista D: The paludisme in the Amazon: a contribution to epidemiology, protozoology and clinics, study about the billiary-hemoglobinuric fever. 1946, Rio de Janeiro: Imprensa Nacional
Moura EFA, Kawachi J, Mattos MNR, Cavalcante RS, Duarte AN: Neonatal malaria: report of a case. J Pediatr (Rio J). 1987, 62: 279-280.
Severo V, Severo MMS, Behar PR, Dossin TJ: Laboratory profile of malarial patients. J Bras Med. 1994, 67: 141-154.
Pinheiro MCN, Branco E, Barata ACS, Dantas RTS, Fernandes WCS: Malaria during the pregnancy and low birth weight from endemic areas in the Amazon. Rev Para Med. 2002, 16: 25-28.
Vermehren R, Cardoso AD, Bulbol WS, Franco M, Coelho K, Lorenzi F, Nunes V, Gonçalves J: Report of a case of acute renal failure in Plasmodium vivax malaria. J Bras Nefrol. 2005, 27:
Cabral PHO, Andrade SD, Alecrim WD, Alecrim MGC, Lacerda MVG: Malaria and sickle cell anemia: report of complications and clinical management of three patients in a highly endemic area for Plasmodium vivax malaria in the Brazilian Amazon. Case Rep Clin Pract Rev. 2006, 7: 220-223.
Alecrim MGC, Silva VMQ, Melo MD, Araújo JR, Guerra MVF, Silva NB, Ferreira LCL, Silva EB, Alecrim WD: Splenic rupture in malarial patients from the Instituto de Medicina Tropical de Manaus [abstract]. Rev Soc Bras Med Trop. 1995, 28: 151
Kalmar EMN, Cassetari V, Machado FR, Alencar F, Kirchgatter K, Boulos M, Tapajós R: Severe malaria in patient with Plasmodium vivax infection: a case report [abstract]. Rev Soc Bras Med Trop. 1998, 31: 56
Sardinha YF, Nunes SB, Albuquerque SRL, Marques HO, Passos LNM: Hemolytic anemia due to secondary cryoagglutinins and P. vivax malaria: report of two cases [abstract]. Rev Soc Bras Med Trop. 1998, 31: 144
Victoria MB, Victoria F, Coellho AHV, Santos LO, Alecrim MGC: Thrombocytopenic purpura in patient with Plasmodium vivax malaria: case report [abstract]. Rev Soc Bras Med Trop. 1998, 31: 55
Zumpano JF, Queiroz JN, Rocha MOC: Spontaneous splenic rupture in vivax malaria [abstract]. Rev Soc Bras Med Trop. 1998, 31: 46
Silva SL, Santana Filho FS, Arcanjo ARL, Alecrim WD, Alecrim MGC: Clinical and hematological profile of hospitalized patients with vivax malaria and thrombocytopenia in the Fundação de Medicina Tropical do Amazonas, from January 2007 to September 1999 [abstract]. Rev Soc Bras Med Trop. 2000, 33: 348
Aragão PS, Alecrim MGC, Evangelista NMA, Tavares AM, Santana Filho FS, Alecrim WD: Clinical and laboratorial study on Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2001, 34: 341
Evangelista NMA, Aragão DS, Tavares AM, Magalhães L, Alexandre MAA, Alecrim MGC, Alecrim WD: Neonatal malaria due to Plasmodium vivax in the Fundação de Medicina Tropical do Amazonas [abstract]. Rev Soc Bras Med Trop. 2002, 35: 344
Moura ACL, Balbo BEP, Cancela ALE, Betti MH, Heneine RAD, Zumpano JF: Death due to P. vivax in a non-endemic area [abstract]. Rev Soc Bras Med Trop. 2002, 35: 369
Park CHL, Ferreira CB, Bianchi CP, Fazio FS, Costa JC, Padilha ARS, Fonseca MO, Boulos M: Thrombocytopenia in patients with Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2002, 35: 370
Viana GMC, Monteiro PS, Nascimento MDSB, Burarttini MN: Severe malaria due to P. vivax: case report [abstract]. Rev Soc Bras Med Trop. 2002, 35: 367
Albuquerque BC, Couto BB, Moraes TC, Couto S: The relevance of clinical and laboratorial aspects in patients with Plasmodium vivax malaria hospitalized in the Fundação de Medicina Tropical do Amazonas, 2002 [abstract]. Rev Soc Bras Med Trop. 2003, 36: 280
Lacerda MVG, Manso MRC, Ferreira LCL, Silva FM, Santos PJT, Alecrim WD, Alecrim MGC: Patient with vivax malaria and acute lung edema in the Brazilian Amazon: case report and literature review [abstract]. Rev Soc Bras Med Trop. 2003, 36: 281
Silva IBA, Araújo JR, Cleonardo A, Ventura AM, Pinto AY, Linonati RMF, Silva Filho M, Valente MIA, Castro JAA, Souza JM: Severe vivax malaria and non-cardiogenic pulmonary edema [abstract]. Rev Soc Bras Med Trop. 2003, 36: 273
Silva IBA, Carneiro MS, Araújo JR, von Mühler CA, Souza JM: Vivax malaria and vasculitis: case evolving with death [abstract]. Rev Soc Bras Med Trop. 2004, 37: 275
Tavares AM, Tavares AM, Cavalcante CP: Splenic subcapsullary hematoma in patient with Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2004, 37: 270
Penna J, Zumpano JF, Penna L, Rocha MOC: Case report: pulmonary manifestations of Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2005, 38: 379
Mello GS, Mello Filho GB, Rodrigues DCH: Malarial coma due to Plasmodium vivax [abstract]. Rev Soc Bras Med Trop. 2006, 39: 106
Menezes CHAB, Martinez-Espinosa FE, Ferreira LCL, Simplicio JL, Frota AC: Effects of malarial infection on the course of pregnancy and fetus in patients from the Fundação de Medicina Tropical do Amazonas [abstract]. Rev Soc Bras Med Trop. 2006, 39: 107
Oliveira RSM, Santos VS, Lacerda MVG, Alecrim WD: Hemolysis associated to acute renal failure in an immunocompetent patient with G6PD deficiency and vivax malaria: case report with favourable evolution [abstract]. Rev Soc Bras Med Trop. 2006, 39: 109
Bastos CJC, Mascarenhas-Batista AV, Freire M, Amorim F, Andrade M, Gomes E: Severe malaria due to Plasmodium vivax: case report [abstract]. Rev Soc Bras Med Trop. 2007, 40: 146
Campos LRP, Mascheretti M, Brasil RA, Duarte MIS: Evaluation of splenic immune response in patient infected with Plasmodium vivax [abstract]. Rev Soc Bras Med Trop. 2007, 40: 141
Cardoso GA, Siqueira GD, Borzacov LMP, Tristão FR, Cardoso LAP, Fontes CJF: Leukemoid reaction caused by Plasmodium vivax: case report [abstract]. Rev Soc Bras Med Trop. 2008, 41: 221 · DOI
Ohnishi MDO, Ventura AM, Linonati RMF, Mendes MM, Apolinário JHD, Souza JM: The lung in vivax malaria: case report [abstract]. Rev Soc Bras Med Trop. 2008, 41: 215
Ohnishi MDO, Linonati RMF, Silva AF, Santos SEB, Ventura AM, Souza JM: Pulmonary manifestations in patients infected with Plasmodium vivax and correlation with TNF-alfa and IL-12 polymorphisms [abstract]. Rev Soc Bras Med Trop. 2010, 43: 84
Urbaez-Brito JD: Clinical and laboratorial characteristics of human malaria and hepatitis B virus association. Master Dissertation. 1995, University of Brasília, Tropical Medicine Department
Alecrim MGC: Clinical aspects, resistance and parasitary polymorphism of Plasmodium vivax malaria in Manaus. PhD Thesis. 2000, University of Brasília, Tropical Medicine Department
Neves JJO: Malaria in Pará: study of the clinical and laboratorial picture in infections caused by Plasmodium vivax. Master Dissertation. 2002, Federal University of Pará
Marques HO: Hemostasis disturbances in patients with malaria. Master Dissertation. 2004, Federal University of São Paulo, Hematology Department
Oliveira MS: Hematological characterization of children with vivax malaria diagnosed and treated in the Fundação de Medicina Tropical do Amazonas. Master Dissertation. 2004, University of the Amazonas State, Health Sciences School
Silva IBA: Vivax malaria: clinical and laboratorial manifestations related to TNF-alpha. PhD Thesis. 2004, Federal University of Pará
Raposo CCBS: Vivax malaria in Maranhão: epidemiological and clinical aspects. Master Dissertation. 2006, University of Brasília, Tropical Medicine Deprtment
Pereira MSS: Study of malaria in pregnant and puerperal women in a public maternity in Manaus from 1999 to 2004. Master Dissertation. 2006, Federal University of Amazonas, Health Sciences School
Guerreiro NSV: Clinical and epidemiological study of Plasmodium vivax malaria in the State of Amapá. Master Dissertation. 2006, Federal University of Pará
Lacerda MVG: Clinical manifestations and pathogenesis of malarial thrombocytopenia. PhD Thesis. 2007, University of Brasília, Tropical Medicine Department
Silva SBR: Evaluation of frequency and factors associated to thrombocytopenia caused by Plasmodium vivax. Master Dissertation. 2009, Federal University of Mato Grosso
Fragoso SCP: Study of 17 cases of autopsies from patients with the diagnosis of vivax malaria in a reference center in the Brazilian Amazon. Master Dissertation. 2010, University of the Amazonas State, Health Sciences School
Lança EFC: Children under 14 years with malaria admitted to Intensive Care Units in the Brazilian Amazon: a case-control study with Plasmodium vivax patients. Master Dissertation. 2011, University of the Amazonas State, Health Sciences School
Lakhkar BB, Babu S, Shenoy V: DIC in vivax malaria. Indian Pediatr. 1996, 33: 971-972.
Ventura AM, Pinto AY, Silva RS, Calvosa VS, Silva Filho MG, Souza JM: Plasmodium vivax malaria in children and adolescents - epidemiological, clinical and laboratory features. J Pediatr (Rio J). 1999, 75: 187-194. · DOI
Orjuela-Sanchez P, Santana Filho FS, Machado-Lima A, Chehuan YF, Costa MR, Alecrim MD, Del Portillo HA: Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine resistant isolates from the Brazilian Amazon region. Antimicrob Agents Chemother. 2009
Pessoa SB: Parasitologia Médica. 1967, Rio de Janeiro: Guanabara-Koogan, 11

Sorted by citations

Items 101–166 of 166

Age-related susceptibility and resistance to nonlethal Plasmodium yoelii infection in C57BL/6 mice
Shan, Y., Liu, J., Jiang, Y., Shang, H., Jiang, D., & Cao, Y. (2012) · Folia Parasitologica · doi:10.14411/fp.2012.021 · Cited by 6
Acute pancreatitis, ascites, and acute renal failure in Plasmodium vivax malaria infection, a rare complication
Pahadiya, H., Lakhotia, M., Kumar, H., Singh, J., Sangappa, J., & Choudhary, P. (2015) · Tropical parasitology · doi:10.4103/2229-5070.162525 · Cited by 6
Is vivax malaria really benign? - a Karachi-based study.
Aatif, S., Jamal, Q., Altaf, A., & Salimullah (2013) · PubMed · Cited by 6
Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates
Schappo, A. P., Bittencourt, N. C., Bertolla, L. P., Forcellini, S., da Silva, A. B. I. E., dos Santos, H. G., Gervásio, J. H. D. B., Lacerda, M., Lopes, S. C. P., Costa, F. T. M., et al. (2021) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760210227 · Cited by 6
Self-citation
Changing pattern of severe manifestations of Plasmodium falciparum and Plasmodium vivax malaria
Acharya, J., & Harwani, D. (2022) · Journal of Vector Borne Diseases · doi:10.4103/0972-9062.342396 · Cited by 5
Slow clearance of Plasmodium vivax with chloroquine amongst children younger than six months of age in the Brazilian Amazon
Siqueira, A. M., Coutinho, L. I., Gurgel, R. L., Su, W. C., Carvalho, L. M., Benzecry, S. G., Alencar, A., Alexandre, M. A. A., Alecrim, M. G. C., & Lacerda, M. (2014) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-0276130068 · Cited by 5
Self-citation
Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β
Velasco-Pareja, M. C., Tovar, C., Guevara, M. E. C., Rodrı́guez, A., Rivera‐Correa, J., & Yasnot, M. F. (2025) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0013284 · Cited by 4
Malaria por Plasmodium vivax o P. falciparum en hospital de tercer nivel en la región más endémica de Colombia
Carmona‐Fonseca, J., Sánchez, Y. L., & Yasnot, M. F. (2015) · Acta Médica Colombiana · doi:10.36104/amc.2015.537 · Cited by 4
Causal effects on low Apgar at 5-min and stillbirth in a malaria maternal–fetal health outcome investigation: a large perinatal surveillance study in the Brazilian Amazon
Seijas-Chávez, J. A., Nolan, M. S., Lynn, M. K., da Rocha, M. J. F., Araújo, M. D. C., Fonseca, F. L. A., & Laporta, G. Z. (2021) · Malaria Journal · doi:10.1186/s12936-021-03981-y · Cited by 4
Allele-specific antibodies to Plasmodium vivax merozoite surface protein-1: prevalence and inverse relationship to haemoglobin levels during infection
Sepúlveda, N., Morais, C. G., Mourão, L. C., Freire, M. F., Fontes, C. J. F., Lacerda, M., DRAKELEY, C. J., & Braga, É. M. (2016) · Malaria Journal · doi:10.1186/s12936-016-1612-z · Cited by 4
Self-citation
Influência da infecção por Plasmodium vivax nos marcadores hematológicos e hepáticos em pacientes de um município da Região Amazônica brasileira
Costa, A. G., Tarragô, A. M., Garcia, N. P., Pimentel, J. P. D., Neves, W. L. L., Melo, G. Z. D. S., Heckmann, M. I. O., & Malheiro, A. (2017) · Revista Pan-Amazônica de Saúde · doi:10.5123/s2176-62232017000200002 · Cited by 4
MALÁRIA: ASPECTOS CLÍNICOS E EPIDEMIOLÓGICOS
Ventura, A. M. R. D. S., Santos, F. M., Setto, J. M., Ohnishi, M. D. D. O., & Libonati, R. M. F. (2025) · Editora Pascal LTDA eBooks · doi:10.29327/5550905.1-14 · Cited by 3
Self-citation
Exploration of Plasmodium vivax merozoite surface proteins 1 and 7 genetic diversity in Brazilian Amazon and Rio de Janeiro Atlantic Forest
Almeida-de-Oliveira, N. K., de Abreu-Fernandes, R., Mello, A. R. D. L., de Pina-Costa, A., Perce-da-Silva, D. D. S., Catanho, M., Rossi, Á. D., Brasil, P., Daniel‐Ribeiro, C. T., & Ferreira‐da‐Cruz, M. D. F. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104592 · Cited by 3
Self-citation
Blood-stage antiplasmodial activity and oocyst formation-blockage of metallo copper-cinchonine complex
Morais, C. M. G., Brito, R. M. D. M., Wesełucha‐Birczyńska, A., Pereira, V. S. D. S., Pereira-Silva, J. W., Menezes, A., Pessoa, F. A. C., Kucharska, M., Birczyńska-Zych, M., Ríos-Velásquez, C. M., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1047269 · Cited by 3
Frequency of Thrombocytopenia in Plasmodium VIVAX Malaria Among Children
Khan, H. U., Jehanzeb, S., Bushra, M., Shaheen, R., Rehman, S. U., & Babar, M. F. U. (2023) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs2023173476 · Cited by 3
A tale of two parasites: a glimpse into the RNA methylome of patient-derived Plasmodium falciparum and Plasmodium vivax isolates
Roy, P., Gujarati, S., Gupta, P., Gupta, I., Mahapatra, T., Gupta, D. K., Kochar, S. K., Kochar, D. K., & Das, A. (2025) · Malaria Journal · doi:10.1186/s12936-025-05376-9 · Cited by 2
Therapeutic efficacy of pyronaridine-artesunate (Pyramax) in treating Plasmodium vivax malaria in the central highlands of Vietnam
Manh, N. D., Thành, N. V., Quang, H. H., Van, N. T. T., San, N. N., Phong, N. C., Birrell, G. W., Edgel, K. A., Martin, N. J., Edstein, M. D., et al. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00044-24 · Cited by 2
Clinical spectrum and predictors of severe Plasmodium vivax infections at a tertiary care center in North India
Walia, D., Arora, U., Baitha, U., Kumar, A., Ranjan, P., Soneja, M., Verma, N., Khan, M. A., Aggarwal, P., Biswas, A., et al. (2020) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2020.03110 · Cited by 2
Pathogenesis of Malarial Parasites in Humans
Chua, C. L. L., Ataíde, R., Umbers, A. J., & Boeuf, P. (2015) · Wiley eBooks · doi:10.1002/9781118644843.ch21 · Cited by 3
Diagnosing Neglected Tropical Diseases in HIV Coinfection
Lindoso (2015) · Human Parasitic Diseases · doi:10.4137/hpd.s19569 · Cited by 1
Síndrome de falla multiorgánica secundario a hematoma esplénico por Plasmodium vivax
Bastidas, A., Quiroga, L. J., Aponte, J. E., Aztorquiza, M. H., & Pérez, C. E. (2014) · Infectio · doi:10.1016/j.infect.2014.02.004 · Cited by 1
Retinal Hemorrhages in Severe Non-cerebral Plasmodium vivax Malaria in an Adult
Lakhotia, M. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/11930.6003 · Cited by 1
VIVAX MALARIA
Mangrio, G. M., Memon, M. A., Shaikh, M. A., Memon, H. N. A., Arwani, S., & Shah, S. Z. A. (2015) · The Professional Medical Journal · doi:10.29309/tpmj/2015.22.05.1267 · Cited by 1
Nutritional status of children with vivax malaria in the Amazon Basin
Dias, R. M., Vieira, J. L. F., Cabral, B. D. C., Ventura, A. M. R. D. S., Leão, P. V., Brasil, L. M. B. F., & de Andrade, M. A. (2017) · Asian Pacific Journal of Tropical Disease · doi:10.12980/apjtd.7.2017d7-147 · Cited by 1
Self-citation
Epidemiological profile of serious malaria in newborns and adolescents served in 2016 in a reference hospital in the State of Amapá, Amazon Region, Brazil
de Brito, M. V., França, A. M. B. D. S., Fecury, A. A., de Oliveira, E., Dendasck, C. V., & Dias, C. A. G. D. M. (2020) · Revista Científica Multidisciplinar Núcleo do Conhecimento · doi:10.32749/nucleodoconhecimento.com.br/saude/malaria-grave · Cited by 1
Эпидемиологический профиль тяжелой малярии у новорожденных и подростков, пролехав в сопровождении 2016 году в справочной больнице в штате Amapá, Бразилия
de Brito, M. V., França, A. M. B. D. S., Fecury, A. A., de Oliveira, E., Dendasck, C. V., & Dias, C. A. G. D. M. (2021) · Revista Científica Multidisciplinar Núcleo do Conhecimento · doi:10.32749/nucleodoconhecimento.com.br/ru/87556 · Cited by 1
Perspectivas para eliminação da malária residual em área rural da Amazônia brasileira: estratégia de busca ativa reativa na identificação de reservatórios de Plasmodium vivax.
Fontoura, P. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-19052017-130115 · Cited by 1
Duffy blood system and g6pd genetic variants in p. Vivax malaria patients from manaus, amazonas, brazilPreprint
Ferreira, N. S., Mathias, J. L. D. S., Albuquerque, S. R. L., de Almeida, A. C. G., Dantas, A. C., Anselmo, F. C., Lima, É. S., Lacerda, M., Nogueira, P. A., Ramasawmy, R., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-41862/v4 · Cited by 1
Self-citation
Estabelecimento de um ensaio funcional de ligação de proteínas de merozoítas de Plasmodium vivax a eritrócitos humanos por citometria de fluxo
Françoso, K. S. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.9.2012.tde-01032013-101304
Geração e análise da imunogenicidade de proteínas recombinantes baseadas nas diferentes formas do antígeno circumsporozoíta de Plasmodium vivax visando o desenvolvimento de uma vacina universal contra malária.
Teixeira, L. H. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2014.tde-11072014-110149
Busca de polimorfismos relacionados à variabilidade do número de episódios de malária na população de Monte Negro (RO).
Pescarini, J. M. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2012.tde-09112012-104048
Polimorfismos dos Genes CD40, CD40L e BLYS, associados na co- estimulação dos Linfócitos B, em indivíduos naturalmente infectados pelo Plasmodium vivax na Amazônia Brasileira.
Capobianco, M. P. (2013) · Americanae (AECID Library)
Avaliação da imunogenicidade de proteínas recombinantes baseadas em antígenos de diferentes estágios do Plasmodium vivax expressos em Pichia pastoris
Lima, L. C. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.9.2014.tde-29092014-150152
Plasmodium vivax
Müeller, I., Bassat, Q., Lacerda, M., & Portillo, H. A. D. (2016) · Wiley eBooks · doi:10.1002/9781118493816.ch20
Self-citation
O papel da heme oxigenase 1 na síndrome do desconforto respiratório agudo associada à malária.
Pereira, M. L. M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2016.tde-11112016-154538
Estudo do modo de transcrição e expressão dos genes surf de Plasmodium falciparum.
Silva, T. M. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2015.tde-27082015-135748
Polimorfismos genéticos de citocinas em indivíduos de área endêmica da Amazônia Legal brasileira com as formas sintomática e assintomática de malária
Domingues, W. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.99.2013.tde-21022014-105246
Análise da diversidade genética e imunogenicidade das proteínas MAEBL e RON2 de Plasmodium vivax
Bittencourt, N. C. (2017) · doi:10.47749/t/unicamp.2017.1081673
Associação entre malária gestacional, restrição do crescimento intrauterino e baixo peso ao nascer na Amazônia extremo-ocidental brasileira.
Dombrowski, J. G. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2019.tde-18042019-161119
A Descriptive Study of Hematologic Characteristics of Malaria Patients Attending A Tertiary Care Hospital in The Region of Kutch
Shah, N. N., & Sinha, R. T. K. (2019) · Annals of Pathology and Laboratory Medicine · doi:10.21276/apalm.2485
Descoberta de derivados 4-quinolinonas como candidatos para desenvolvimento de antimaláricos: Caracterização in vitro, ex vivo e mecanismo de ação
de Souza, J. O. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.76.2019.tde-27052020-112506
Epidemiologisches Profil schwerer Malaria bei Neugeborenen und Jugendlichen, die 2016 in einem Referenzkrankenhaus im brasilianischen Bundesstaat Amapá behandelt wurden
de Brito, M. V., França, A. M. B. D. S., Fecury, A. A., de Oliveira, E., Dendasck, C. V., & Dias, C. A. G. D. M. (2020) · Revista Científica Multidisciplinar Núcleo do Conhecimento · doi:10.32749/nucleodoconhecimento.com.br/gesundheit/schwerer-malaria
Profil épidémiologique du paludisme grave chez les nouveau-nés et les adolescents traités en 2016 dans un hôpital de référence de l’État d’Amapá, au Brésil
de Brito, M. V., França, A. M. B. D. S., Fecury, A. A., de Oliveira, E., Dendasck, C. V., & Dias, C. A. G. D. M. (2020) · Revista Científica Multidisciplinar Núcleo do Conhecimento · doi:10.32749/nucleodoconhecimento.com.br/sante/paludisme-grave
Perfil epidemiológico de la malaria grave en recién nacidos y adolescentes atendidos en 2016 en un hospital de referencia en el Estado de Amapá, Brasil
de Brito, M. V., França, A. M. B. D. S., Fecury, A. A., de Oliveira, E., Dendasck, C. V., & Dias, C. A. G. D. M. (2020) · Revista Científica Multidisciplinar Núcleo do Conhecimento · doi:10.32749/nucleodoconhecimento.com.br/salud/la-malaria-grave
Profilo epidemiologico della malaria grave nei neonati e negli adolescenti trattati nel 2016 in un ospedale di riferimento nello Stato di Amapá, Brasile
de Brito, M. V., França, A. M. B. D. S., Fecury, A. A., de Oliveira, E., Dendasck, C. V., & Dias, C. A. G. D. M. (2020) · Revista Científica Multidisciplinar Núcleo do Conhecimento · doi:10.32749/nucleodoconhecimento.com.br/salute/della-malaria-grave
CLINICAL PROFILE OF PLASMODIUM VIVAX MALARIA IN CHILDREN
Jain, K. K., & Bohra, J. (2021) · International Journal of Medical and Biomedical Studies · doi:10.32553/ijmbs.v5i8.2070
Acute kidney injury in Plasmodium vivax malaria hospitalized patients in Manaus, Brazilian Amazon: are we underestimating the real burden?Preprint
Santos, T. C., Brito-Sousa, J. D., Val, F., Sachett, J. D. A. G., Mo, M. M., Cubas-Vega, N. C., Del-Tejo, P. L., Safe, I. P., Bessa, R. A., Alecrim, M. G. C., et al. (2019) · doi:10.21203/rs.2.17608/v1
Self-citation
A função de antígenos SURFIN e o papel epigenético da putativa demetilase JmjC2 em Plasmodium falciparum.
Silva, T. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2019.tde-03052022-173712
Duffy Blood System and G6PD Genetic Variants In P. Vivax Malaria Patients From Manaus, Amazonas, BrazilPreprint
Ferreira, N. S., Mathias, J. L. D. S., Albuquerque, S. R. L., de Almeida, A. C. G., Dantas, A. C., Anselmo, F. C., Lima, É. S., Lacerda, M., Nogueira, P. A., Ramasawmy, R., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-41862/v3
Self-citation
Duffy Blood System and G6PD Genetic Variants in P. Vivax Malaria Patients From Manaus, Amazonas, BrazilPreprint
Ferreira, N. S., Mathias, J. L. D. S., Albuquerque, S. R. L., de Almeida, A. C. G., Dantas, A. C., Anselmo, F. C., Lima, É. S., Lacerda, M., Nogueira, P. A., Gonçalves, M. D. S., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-41862/v1
Self-citation
Study on clinical presentation of malaria and response to antimalarial treatment in children less than twelve years
Goswami, P., Pathak, G. H., & Chauhan, A. V. (2023) · International Journal of Contemporary Pediatrics · doi:10.18203/2349-3291.ijcp20232586
Contribuição de plaquetas e fatores circulantes para a ativação endotelial na malária por Plasmodium vivax
dos Santos, J. C. K. (2022) · doi:10.47749/t/unicamp.2022.1259617
Analyses of the immunopathological and molecular mechanisms involved in cytoadherence of Plasmodium vivax
Bourgard, C. (2019) · doi:10.47749/t/unicamp.2019.1162221
Avaliação "in vitro" e "in vivo" do potencial antimalárico da Epirrubicina
Ferreira, L. T. (2019) · doi:10.47749/t/unicamp.2019.1162431
AVALIAÇÃO DE TECNOLOGIA EM SAÚDE NO CONTEXTO DAS DOENÇAS INFECCIOSAS
da Costa, C. M. M., Costa, L. P. D. S., & Carneiro, S. R. (2025) · Editora Pascal LTDA eBooks · doi:10.29327/5550905.1-1
COVID-19 AGUDA E DE LONGA DURAÇÃO: A COMPLEXIDADE DA DISFUNÇÃO MUSCULAR
Silva, C. C., Quaresma, J. A. S., & Falcão, L. F. M. (2025) · Editora Pascal LTDA eBooks · doi:10.29327/5550905.1-10
AVALIAÇÃO E INTERVENÇÃO RESPIRATÓRIA NA COVID-19
Dias, Á. R. N., Filho, L. E. C. D. S., Falcão, L. F. M., & Normando, V. M. F. (2025) · Editora Pascal LTDA eBooks · doi:10.29327/5550905.1-12
AVALIAÇÃO DO CONTROLE URINÁRIO DE PACIENTES INFECTADOS
Nunes, É. F. C., Teixeira, T. A., & Rodrigues, C. N. C. (2025) · Editora Pascal LTDA eBooks · doi:10.29327/5550905.1-6
AVALIAÇÃO DAS DISFUNÇÕES OLFATIVAS EM PACIENTES DE COVID-19
Paranhos, A. C. M., Dias, Á. R. N., Koury, G. V. H., & Souza, G. D. S. (2025) · Editora Pascal LTDA eBooks · doi:10.29327/5550905.1-11
AVALIAÇÃO SENSÓRIO-MOTORA EM HANSENÍASE
Cabral, A. D. S., Lopes, G. L., & Santos, L. L. S. (2025) · Editora Pascal LTDA eBooks · doi:10.29327/5550905.1-3
Additional file 2 of Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
Ferreira, N. S., Mathias, J. L. D. S., Albuquerque, S. R. L., Almeida, A. C. G., Dantas, A. C., Anselmo, F. C., Lima, E. S., Lacerda, M. V. G., Nogueira, P. A., Ramasawmy, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19731735
Self-citation
Additional file 1 of Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
Ferreira, N. S., Mathias, J. L. D. S., Albuquerque, S. R. L., Almeida, A. C. G., Dantas, A. C., Anselmo, F. C., Lima, E., Lacerda, M. V. G., Nogueira, P. A., Ramasawmy, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19731732
Self-citation
Additional file 2 of Causal effects on low Apgar at 5-min and stillbirth in a malaria maternal–fetal health outcome investigation: a large perinatal surveillance study in the Brazilian Amazon
Seijas-Chávez, J. A., Nolan, M. S., Lynn, M. K., da Rocha, M. J. F., da Costa Araújo, M., Fonseca, F. L. A., & Laporta, G. Z. (2021) · Figshare · doi:10.6084/m9.figshare.17083757
Additional file 1 of Causal effects on low Apgar at 5-min and stillbirth in a malaria maternal–fetal health outcome investigation: a large perinatal surveillance study in the Brazilian Amazon
Seijas-Chávez, J. A., Nolan, M. S., Lynn, M. K., da Rocha, M. J. F., da Costa Araújo, M., Fonseca, F. L. A., & Laporta, G. Z. (2021) · Figshare · doi:10.6084/m9.figshare.17083751
Transcriptomics of Plasmodium vivax rosetting
Bourgard, C., Ferraboli, J. W., Lopes, S. C. P., Lacerda, M., Sunnerhagen, P., Albrecht, L., & Costa, F. T. M. (2026) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760250198
Self-citation
Imported mosquito-borne infectious diseases in travelers and migrants: Global patterns, clinical overlap, and prevention gaps—an umbrella review of 21 systematic reviews
Sha, T., Liao, Z., Yuan, T., Wang, Y., Liang, W., Xu, E., Zhang, X., Li, Z., Zhao, J., Müller, O., et al. (2026) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2026.109160

Authors: Lacerda, M. V., Mourão, M. P., Alexandre, M. A., Siqueira, A. M., Magalhães, B. M., Martinez-Espinosa, F. E., Santana Filho, F. S., Brasil, P., Ventura, A. M., Tada, M. S., Couto, V. S., Silva, A. R., Silva, R. S., & Alecrim, M. G.
Affiliations: Fundação de Medicina Tropical (BR)
Fundação Oswaldo Cruz (BR)
Universidade Federal do Maranhão (BR)
Universidade Federal do Acre (BR)
Corresponding author: Lacerda, Marcus VG
ORCID: Lacerda, Marcus VG
Siqueira, André M
Brasil, Patrícia
Tada, Mauro S
Venue: Malaria Journal
Publisher: Springer Science and Business Media LLC
Published: 2012-01-09
Volume: 11
Issue: 1
Pages: 12-12
ISSN: 1475-2875 (ISSN-L)
DOI: 10.1186/1475-2875-11-12
PMC: PMC3268102
OpenAlex: W2138295263
Cited by: 158
References: 136
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 16 · 2019: 9 · 2018: 7 · 2017: 11 · 2016: 19 · 2015: 20 · 2014: 20 · 2013: 17 · 2012: 10
FWCI: 3.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/2.0 (tdm)
Locations: Malaria Journal (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Americanae (AECID Library) (submittedVersion, other-oa)
Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Fundação de Amparo à Pesquisa do Estado do Amazonas
Fundação de Amparo à Pesquisa do Estado de Mato Grosso
Ministério da Saúde
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Keywords: Plasmodium vivax, severe malaria, clinical features, anemia, thrombocytopenia, jaundice, acute respiratory distress syndrome, malaria in pregnancy, comorbidities, publication bias, Brazilian Amazon, travellers
MeSH terms: Brazil, Female, Geography, Humans, Male, Plasmodium vivax, Pregnancy, Pregnancy Complications, Infectious, Survival Analysis, Malaria, Vivax

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks