The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements
Open accessAbstract
Multivitamin/multimineral complexes are the most common dietary supplements. Unlike minerals in foods that are incorporated in bioorganic structures, minerals in dietary supplements are typically in an inorganic form. These minerals can catalyze the generation of free radicals, thereby oxidizing antioxidants during digestion. Here we examine the ability of a matrix consisting of an amino acid and non-digestible oligosaccharide (AAOS) to blunt metal-catalyzed oxidations. Monitoring of ascorbate radical generated by copper shows that ascorbate is oxidized more slowly with the AAOS matrix than with copper sulfate. Measurement of the rate of oxidation of ascorbic acid and Trolox® by catalytic metals confirmed the ability of AAOS to slow these oxidations. Similar results were observed with iron-catalyzed formation of hydroxyl radicals. When compared to traditional forms of minerals used in supplements, we conclude that the oxidative loss of antioxidants in solution at physiological pH is much slower when AAOS is present.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In inorganic form, minerals are capable of catalyzing free radical generation.
“In this form, minerals are capable of catalyzing free radicals generation (Rabovsky et al., 2010).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Rabovsky et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hempel, S. L., Buettner, G. R., O’Malley, Y. Q., Wessels, D. A., & Flaherty, D. M. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00061-1 · Cited by 740
Self-citation
Flagged first, then by citations
Research works printed but not linked: 32
- Economic Characterization of the Dietary Supplement Industry: U. S. Food and Drug Administration. Center for Food Safety and Applied Nutrition, Section 5. 1999
- Buettner GR: Ascorbate autoxidation in the presence of iron and copper chelates. Free Radic.Res.Commun. 1986, 1: 349-353. 10.3109/10715768609051638. · DOI
- Buettner GR: In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals. J.Biochem.Biophys.Methods. 1988, 16: 27-40. 10.1016/0165-022X(88)90100-5. · DOI
- Gallo-Torres HE, Machlin LJ: Part 5B/Transport and metabolism. Vitamin E: A Comprehensive Treatise. 1980, New York: Marcel Dekker, Inc, 193-267.
- Wagner BA, Buettner GR, Burns CP: Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content. Biochemistry. 1994, 33: 4449-4453. 10.1021/bi00181a003. · DOI
- Khan MM, Martell AE: Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. II. Cupric and ferric chelate catalyzed oxidation. J.Am.Chem.Soc. 1967, 89: 7104-7111. 10.1021/ja01002a046. · DOI
- Udenfriend S, Clark CT, Axelrod J, Brodie BB: Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation. J.Biol.Chem. 1954, 208: 731-739. · DOI
- Wagner BA, Buettner GR, Burns CP: Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content. Biochemistry. 1994, 33: 4449-4453. 10.1021/bi00181a003. · DOI
- Maskos Z, Koppenol WH: Oxyradicals and multivitamin tablets. Free Radic.Biol.Med. 1991, 11: 609-610. 10.1016/0891-5849(91)90142-P. · DOI
- Fisher AE, Naughton DP: Iron supplements: the quick fix with long-term consequences. Nutr.J. 2004, 3: 2-10.1186/1475-2891-3-2. · DOI · Paper page
- Abrams SA, Hawthorne KM, Aliu O, Hicks PD, Chen Z, Griffin IJ: An inulin-type fructan enhances calcium absorption primarily via an effect on colonic absorption in humans. J.Nutr. 2007, 137: 2208-2212. · DOI
- Bosscher D, Van Caillie-Bertrand M, Vanb Cauwenbergh R, Deelstra H: Availabilities of calcium, iron, and zinc from dairy infant formulas is affected by soluble dietary fibers and modified starch fractions. Nutrition. 2003, 19: 641-645. 10.1016/S0899-9007(03)00063-7. · DOI
- Coudray C, Rambeau M, Feillet-Coudray C, et al: Dietary inulin intake and age can significantly affect intestinal absorption of calcium and magnesium in rats: a stable isotope approach. Nutr.J. 2005, 4: 29-10.1186/1475-2891-4-29. · DOI
- Devareddy L, Khalil DA, Korlagunta K, Hooshmand S, Bellmer DD, Arjmandi BH: The effects of fructo-oligosaccharides in combination with soy protein on bone in osteopenic ovariectomized rats. Menopause. 2006, 13: 692-699. 10.1097/01.gme.0000195372.74944.71. · DOI
- Nzeusseu A, Dienst D, Haufroid V, Depresseux G, Devogelaer JP, Manicourt DH: Inulin and fructo-oligosaccharides differ in their ability to enhance the density of cancellous and cortical bone in the axial and peripheral skeleton of growing rats. Bone. 2006, 38: 394-399. 10.1016/j.bone.2005.09.006. · DOI
- Roberfroid MB, Cumps J, Devogelaer JP: Dietary chicory inulin increases whole-body bone mineral density in growing male rats. J.Nutr. 2002, 132: 3599-3602. · DOI
- Crow JP: Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species. Nitric.Oxide. 1997, 1: 145-157. 10.1006/niox.1996.0113. · DOI
- Basosi R, Pogni R, Lunga GD: Coordination modes of histidine moiety in copper (II) dipeptide complexes detected by multifrequency ESR. Bull.Magn.Res. 1992, 14: 224-228.
- Buettner GR: In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals. J.Biochem.Biophys.Methods. 1988, 16: 27-40. 10.1016/0165-022X(88)90100-5. · DOI
- Khan MM, Martell AE: Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. I. Cupric and ferric ion catalyzed oxidation. J.Am.Chem.Soc. 1967, 89: 4176-4185. 10.1021/ja00992a036. · DOI
- Buettner GR, Jurkiewicz BA: Ascorbate free radical as a marker of oxidative stress: an EPR study. Free Radic.Biol.Med. 1993, 14: 49-55. 10.1016/0891-5849(93)90508-R. · DOI
- Sharma MK, Buettner GR: Interaction of vitamin C and vitamin E during free radical stress in plasma: an ESR study. Free Radic. Biol. Med. 1993, 14: 649-653. 10.1016/0891-5849(93)90146-L. · DOI
- Walling C: Fenton's Reagent Revisited. Acc.Chem.Res. 1975, 8: 125-131. 10.1021/ar50088a003. · DOI
- Buettner GR: Spin trapping: ESR parameters of spin adducts. Free Radic.Biol.Med. 1987, 3: 259-303. 10.1016/S0891-5849(87)80033-3. · DOI · Paper page
- Scott JW, Cort WM, Harley H, Parrish DR, Saucy G: 6-Hydroxychroman-2-carboxylic acids: Novel antioxidants. J.Am.Oil Chem.Soc. 1974, 51: 200-203. 10.1007/BF02632894. · DOI
- Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C: Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic.Biol.Med. 1999, 26: 1231-1237. 10.1016/S0891-5849(98)00315-3. · DOI
- Gilbert BC, Kamp NW, Smith JRL, Oakes J: EPR evidence for one-electron oxidation of phenols by a dimeric manganese(IV/IV) triazacyclononane complex in the presence and absence of hydrogen peroxide. J.Chem., Perkin Trans.2. 1997, 2161-2165. 10.1039/a704330i. · DOI
- Abrams SA, Hawthorne KM, Aliu O, Hicks PD, Chen Z, Griffin IJ: An inulin-type fructan enhances calcium absorption primarily via an effect on colonic absorption in humans. J.Nutr. 2007, 137: 2208-2212. · DOI
- Bosscher D, Van Caillie-Bertrand M, Van Cauwenbergh R, Deelstra H: Availabilities of calcium, iron, and zinc from dairy infant formulas is affected by soluble dietary fibers and modified starch fractions. Nutrition. 2003, 19: 641-645. 10.1016/S0899-9007(03)00063-7. · DOI
- Devareddy L, Khalil DA, Korlagunta K, Hooshmand S, Bellmer DD, Arjmandi BH: The effects of fructo-oligosaccharides in combination with soy protein on bone in osteopenic ovariectomized rats. Menopause. 2006, 13: 692-699. 10.1097/01.gme.0000195372.74944.71. · DOI
- Nzeusseu A, Dienst D, Haufroid V, Depresseux G, Devogelaer JP, Manicourt DH: Inulin and fructo-oligosaccharides differ in their ability to enhance the density of cancellous and cortical bone in the axial and peripheral skeleton of growing rats. Bone. 2006, 38: 394-399. 10.1016/j.bone.2005.09.006. · DOI
- Roberfroid MB, Cumps J, Devogelaer JP: Dietary chicory inulin increases whole-body bone mineral density in growing male rats. J.Nutr. 2002, 132: 3599-3602. · DOI
Cited by
Sorted by citations
Iron, Oxidative Stress and Health
Udipi, S., Ghugre, P., & Gokhale, C. (2012) · Oxidative Stress - Molecular Mechanisms and Biological Effects · doi:10.5772/34975 · Cited by 17
“In this form, minerals are capable of catalyzing free radicals generation (Rabovsky et al., 2010).”
Background
Metadata
- Authors
- Rabovsky, A. B., Komarov, A. M., Ivie, J. S., & Buettner, G. R.
- Affiliations
- George Washington University (US)
- University of Iowa (US)
- Corresponding author
- Rabovsky, Alexander B
- ORCID
- Buettner, Garry R
- Venue
- Nutrition Journal
- Published
- 2010-11-23
- Volume
- 9
- Issue
- 1
- Pages
- 61-61
- ISSN
- 1475-2891 (ISSN-L)
- PMC
- PMC3002910
- OpenAlex
- W2135299824
- Cited by
- 13
- References
- 1
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2015: 3 · 2012: 2
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrition Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- oxidative damage, metal catalysis, copper-catalyzed oxidation, ascorbic acid oxidation, non-digestible oligosaccharides, antioxidant degradation, inorganic minerals, dietary supplements
- MeSH terms
- Amino Acids, Antioxidants, Ascorbic Acid, Catalysis, Chelating Agents, Chromans, Copper, Free Radicals, Iron, Kinetics, Minerals, Oligosaccharides, Oxidation-Reduction, Pharmaceutic Aids, Vitamins, Free Radical Scavengers, Oxidative Stress, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
