The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer
Open accessAbstract
BACKGROUND: Accumulating evidence indicates that the long non-coding RNA HOTAIR plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical significance of HOTAIR in gastric carcinogenesis remains largely unknown. METHODS: HOTAIR expression was measured in 78 paired cancerous and noncancerous tissue samples by real-time PCR. The effects of HOTAIR on gastric cancer cells were studied by overexpression and RNA interference approaches in vitro and in vivo. Insights of the mechanism of competitive endogenous RNAs (ceRNAs) were gained from bioinformatic analysis, luciferase assays and RNA binding protein immunoprecipitation (RIP). The positive HOTAIR/HER2 interaction was identified and verified by immunohistochemistry assay and bivariate correlation analysis. RESULTS: HOTAIR upregulation was associated with larger tumor size, advanced pathological stage and extensive metastasis, and also correlated with shorter overall survival of gastric cancer patients. Furthermore, HOTAIR overexpression promoted the proliferation, migration and invasion of gastric carcinoma cells, while HOTAIR depletion inhibited both cell invasion and cell viability, and induced growth arrest in vitro and in vivo. In particular, HOTAIR may act as a ceRNA, effectively becoming a sink for miR-331-3p, thereby modulating the derepression of HER2 and imposing an additional level of post-transcriptional regulation. Finally, the positive HOTAIR/HER2 correlation was significantly associated with advanced gastric cancers. CONCLUSIONS: HOTAIR overexpression represents a biomarker of poor prognosis in gastric cancer, and may confer malignant phenotype to tumor cells. The ceRNA regulatory network involving HOTAIR and the positive interaction between HOTAIR and HER2 may contribute to a better understanding of gastric cancer pathogenesis and facilitate the development of lncRNA-directed diagnostics and therapeutics against this disease.
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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Long non-coding RNAs: insights into functions
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Complex architecture and regulated expression of the Sox2ot locus during vertebrate development
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Long non-coding RNAs and complex diseases: from experimental results to computational models
Chen, X., Yan, C. C., Zhang, X., & You, Z.-H. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw060 · Cited by 567
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Self-citationCirculating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers
Hamam, R., Hamam, D., Alsaleh, K. A., Kassem, M., Zaher, W., Alfayez, M., Aldahmash, A., & Alajez, N. M. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.440 · Cited by 322
Long noncoding RNAs: a potential novel class of cancer biomarkers
Yarmishyn, A. A., & Kurochkin, I. V. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00145 · Cited by 273
Identification of functional lncRNAs in gastric cancer by integrative analysis of GEO and TCGA data
Zhang, X., Zhang, W., Jiang, Y., Liu, K., Ran, L., & Song, F. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29058 · Cited by 78
Metadata
- Authors
- Liu, X.-H., Sun, M., Nie, F.-Q., Ge, Y.-B., Zhang, E.-B., Yin, D.-D., Kong, R., Xia, R., Lu, K.-H., Li, J.-H., De, W., Wang, K.-M., & Wang, Z.-X.
- Venue
- Molecular Cancer
- Published
- 2014-04-28
- Volume
- 13
- Issue
- 1
- Pages
- 92-92
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2136222002
- Cited by
- 946
- References
- 4
- FWCI
- 28.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, X.-H., Sun, M., Nie, F.-Q., Ge, Y.-B., Zhang, E.-B., Yin, D.-D., Kong, R., Xia, R., Lu, K.-H., Li, J.-H., De, W., Wang, K.-M., & Wang, Z.-X. (2014). Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Molecular Cancer. https://doi.org/10.1186/1476-4598-13-92
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