The DOI matches its Crossref record, with a small difference in title or year; 1 of the 1 references it cites were found in a registry or an index.
Comparison of platelet function between sedentary individuals and competitive athletes at rest.
Open accessAbstract
BACKGROUND: There are controversial evidences on the effect of different types and workloads of physical exercise on primary hemostasis. In particular, little is known on the chronic influence of a strenuous and regular aerobic training regimen on platelet function. METHODS: The aim of this investigation was to compare platelet function between sedentary controls and trained athletes at rest and to evaluate whether a greater amount of exercise performed in professional cyclists may contribute to increased platelet chronic responsiveness compared to both elite cyclists and sedentary individuals. Platelet's ability to adhere and aggregate was assayed following a 12-24 h resting period in 49 active professional male road cyclists, 40 elite male cyclists and 43 matched sedentary healthy male volunteers, by the platelet function analyzer 100 (PFA-100). RESULTS AND DISCUSSION: Mean values of the collagen-epinephrine test did not differ between controls and athletes (sedentary controls: 111 +/- 33 s; elite athletes: 113 +/- 26 s, p = 0.93; professional athletes: 120 +/- 33 s; p = 0.33), whereas mean values of the collagen-ADP test displayed a slightly but significant trend towards decreased values when comparing sedentary controls (83 +/- 21 s) with either elite (77 +/- 11 s, p < 0.01) or professional (75 +/- 16 s, p < 0.01) athletes. CONCLUSION: The trend towards slightly lower collagen-ADP values are suggestive for a modest but significant chronic activation of primary hemostasis, highlighting the need to set appropriate reference ranges for the PFA-100 when evaluating primary hemostasis in physically active subjects.
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Some studies have shown that failure to mix the primary blood tube most probably will not introduce a bias in many test results.
“Some studies have shown that failure to mix the primary blood tube most probably will not introduce a bias in many test results.”
From Joint EFLM-COLABIOCLI Recommendation for venous blood sampling (2018) · cites this paper as [92]
The Methods (page unavailable) describe blood collection and processing, but do not say whether the primary tubes were mixed or assess the effect of not mixing them. The Conclusion (page unavailable) concerns platelet-function results in athletes, not bias across laboratory tests. Searches for failure to mix tubes and for tube inversion found no passage addressing the claim. (LLM, conf=0.76)
Experimental — accuracy not yet measuredIf applied for longer than 1 min, a tourniquet induces a substantial variation of blood composition due to extravasation of water and small molecules such as ions from the vessel into the subendothelial space.
“If applied for a long period of time (longer than 1 min) a tourniquet induces a substantial variation of blood composition, due to extravasation of water and small molecules such as ions from the vessel into the subendothelial space.”
From Joint EFLM-COLABIOCLI Recommendation for venous blood sampling (2018) · cites this paper as [86]
The Methods section describes venipuncture and sample handling but does not discuss tourniquet duration. Searches for tourniquet use beyond one minute and for extravasation or hemoconcentration found no passage addressing the claimed change in blood composition. No page numbers are available in our copy. (LLM, conf=0.75)
Experimental — accuracy not yet measuredTourniquets cause a temporary occlusion of veins and temporary venous stasis.
“Tourniquets cause a temporary occlusion of veins and temporary venous stasis.”
From Joint EFLM-COLABIOCLI Recommendation for venous blood sampling (2018) · cites this paper as [86]
The Methods section describes blood collection by venipuncture but does not mention tourniquets, venous occlusion, or venous stasis. Searches for those terms and for tourniquet use during blood sampling found no passage addressing the claim. (LLM, conf=0.75)
Experimental — accuracy not yet measuredMost changes from tourniquet application are negligible within 1 min but can become clinically significant afterwards.
“Most of these changes are negligible within 1 min of the application of the tourniquet, but can become clinically significant afterwards [84], [85], [86].”
From Joint EFLM-COLABIOCLI Recommendation for venous blood sampling (2018) · cites this paper as [86]
The Methods section describes venipuncture and sample handling, but does not discuss tourniquet use. Searches for tourniquet application, venous stasis, and a one-minute threshold found no passage addressing when tourniquet-related changes become clinically significant. (LLM, conf=0.75)
Experimental — accuracy not yet measuredDuring tourniquet application, large molecules such as lipoprotein particles, proteins and protein-bound substances, cells and coagulation factors remain within the vessel, so their concentration progressively increases.
“During that process, large molecules such as lipoprotein particles, proteins and protein-bound substances, cells and coagulation factors remain within the vessel, so that their concentration progressively increases.”
From Joint EFLM-COLABIOCLI Recommendation for venous blood sampling (2018) · cites this paper as [86]
The Methods section describes venipuncture and sample handling but does not discuss tourniquet application. A search of our copy for tourniquet-related hemoconcentration found no passage stating that the listed blood components remain in the vessel or progressively increase in concentration. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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Citations
Cites
Relative Intensity of Physical Activity and Risk of Coronary Heart Disease
Lee, I.-M., Sesso, H. D., Oguma, Y., & Paffenbarger, R. S. (2003) · Circulation · doi:10.1161/01.cir.0000052626.63602.58 · Cited by 347
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- Lippi G Franchini M Laboratory screening for abnormalities of primary hemostasis: what's next? Clin Chem 2001 47 2071 11673390
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- Lippi G Salvagno GL Montagana M Guidi GC Chronic influence of vigorous aerobic training on hemostasis Blood Coagul Fibrinolysis 2005 16 533 4 16175015
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Cited by
Sorted by citations
Joint EFLM-COLABIOCLI Recommendation for venous blood sampling
Simundic, A.-M., Bölenius, K., Cadamuro, J., Church, S., Cornes, M. P., van Dongen-Lases, E. C., Eker, P., Erdeljanovic, T., Grankvist, K., Guimaraes, J. T., et al. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2018-0602 · Cited by 240
Self-citationBiological Influence of Physical Exercise on Hemostasis
Lippi, G., & Maffulli, N. (2009) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0029-1222605 · Cited by 139
Self-citation
Metadata
- Authors
- Lippi, G., Montagnana, M., Salvagno, G. L., Franchini, M., & Guidi, G. C.
- Affiliations
- University of Verona (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Corresponding author
- Giuseppe Lippi
- Venue
- Thrombosis Journal
- Published
- 2006
- Volume
- 4
- Issue
- 1
- Pages
- 10
- ISSN
- 1477-9560 (ISSN-L)
- PMC
- PMC1562367
- OpenAlex
- W2122582764
- Cited by
- 11
- References
- 1
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Thrombosis Journal (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Keywords
- platelet function, primary hemostasis, professional cyclists, elite cyclists, sedentary individuals, aerobic exercise, exercise training, platelet aggregation, platelet adhesion
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