The human proteome – a scientific opportunity for transforming diagnostics, therapeutics, and healthcare
Open accessAbstract
A National Institutes of Health (NIH) workshop was convened in Bethesda, MD on September 26-27, 2011, with representative scientific leaders in the field of proteomics and its applications to clinical settings. The main purpose of this workshop was to articulate ways in which the biomedical research community can capitalize on recent technology advances and synergize with ongoing efforts to advance the field of human proteomics. This executive summary and the following full report describe the main discussions and outcomes of the workshop.
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It is now possible to reliably obtain quantitative observations for tens of thousands of peptides derived from up to 10,000 proteins per sample, and steps have been taken toward profiling the entire human proteome.
“Despite this limitation, it is now possible to reliably obtain quantitative observations for tens of thousands of peptides derived from up to 10,000 proteins per sample22, and very recently important steps have been taken toward profiling the entire human proteome23,24.”
From Decoding neuroproteomics: integrating the genome, translatome and functional anatomy (2014) · cites this paper as [22]
Proteomics enables proteome-wide validation of genomic and transcriptomic variants, allelic imbalance, and isoform identification.
“An additional major attraction of proteomics lies in the peptide sequences, which enables proteome-wide validation of genomic and transcriptomic variants, allelic imbalance, and isoform identification22 (Figure 1).”
From Decoding neuroproteomics: integrating the genome, translatome and functional anatomy (2014) · cites this paper as [22]
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References 36 · Cited by 41
- Authors
- Vidal, M., Chan, D. W., Gerstein, M., Mann, M., Omenn, G. S., Tagle, D., Sechi, S., & Participants, W.
- Affiliations
- University of Michigan (US)
- Johns Hopkins University (US)
- Yale University (US)
- Max Planck Institute of Biochemistry (DE)
- National Institute of Neurological Disorders and Stroke (US)
- National Institutes of Health (US)
- Corresponding author
- Omenn, Gilbert S
- Sechi, Salvatore
- Venue
- Clinical Proteomics
- Published
- 2012-07-03
- Volume
- 9
- Issue
- 1
- Pages
- 6-6
- ISSN
- 1542-6416 (ISSN-L)
- 1559-0275
- PMC
- PMC3388576
- OpenAlex
- W2162538520
- Cited by
- 41
- References
- 36
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 4
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Clinical Proteomics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- human proteome, healthcare transformation
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