Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability

Gupta, Shakti; Aslakson, Eric; Gurbaxani, Brian M; Vernon, Suzanne D

doi:10.1186/1742-4682-4-8

Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability

Background The body's primary stress management system is the hypothalamic pituitary adrenal (HPA) axis. The HPA axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's cortisol level. Dysregulation of the HPA axis is implicated in numerous stress-…