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Cited by 926

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure

Open access
Donaldson, Ken, Tran, Lang, Jimenez, Luis Albert, Duffin, Rodger, Newby, David E, Mills, Nicholas, MacNee, William, Stone, Vicki·2005·Particle and Fibre Toxicology

Abstract

This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the lungs through their potential to cause oxidative stress, inflammation and cancer; they also have the potential to redistribute to other organs following pulmonary deposition. These different CDNP show considerable heterogeneity in composition and solubility, meaning that oxidative stress may originate from different components depending on the particle under consideration. Key CDNP-associated properties of large surface area and the presence of metals and organics all have the potential to produce oxidative stress. CDNP may also exert genotoxic effects, depending on their composition. CDNP and their components also have the potential to translocate to the brain and also the blood, and thereby reach other targets such as the cardiovascular system, spleen and liver. CDNP therefore can be seen as a group of particulate toxins unified by a common mechanism of injury and properties of translocation which have the potential to mediate a range of adverse effects in the lungs and other organs and warrant further research.

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Metadata

Authors
Donaldson, K., Tran, L., Jimenez, L. A., Duffin, R., Newby, D. E., Mills, N., MacNee, W., & Stone, V.
Venue
Particle and Fibre Toxicology
Published
2005-10-21
Volume
2
Issue
1
Pages
10-10
ISSN
1743-8977 (ISSN-L)
OpenAlex
W2129689267
Cited by
926
References
5
FWCI
24.02
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. https://app.cochat.ai/papers/10.1186/1743-8977-2-10
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Donaldson, K., Tran, L., Jimenez, L. A., Duffin, R., Newby, D. E., Mills, N., MacNee, W., & Stone, V. (2005). Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. Particle and Fibre Toxicology. https://doi.org/10.1186/1743-8977-2-10

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