A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging
Open accessAbstract
The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects. Our current understanding of alterations in cortical and sub-cortical regions in pain suggests that the BG are uniquely involved in thalamo-cortico-BG loops to integrate many aspects of pain. These include the integration of motor, emotional, autonomic and cognitive responses to pain.
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The basal ganglia, including the NAc, is involved in processing multiple aspects of pain.
“The basal ganglia, including the NAc, is involved in processing multiple aspects of pain [49].”
From Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain (2015) · cites this paper as [49]
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References 188 · Cited by 326
- Authors
- Borsook, D., Upadhyay, J., Chudler, E. H., & Becerra, L.
- Affiliations
- Harvard University (US)
- University of Washington (US)
- Corresponding author
- Borsook, David
- Venue
- Molecular Pain
- Publisher
- SAGE Publications
- Published
- 2010-01-01
- Volume
- 6
- Pages
- 27-27
- ISSN
- 1744-8069 (ISSN-L)
- PMC
- PMC2883978
- OpenAlex
- W2113226190
- Cited by
- 326
- References
- 188
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 23 · 2023: 20 · 2022: 32 · 2021: 28 · 2020: 20 · 2019: 19 · 2018: 17 · 2017: 20 · 2016: 17 · 2015: 22 · 2014: 24 · 2013: 14 · 2012: 18
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Pain (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Neurological Disorders and Stroke (K24NS064050)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- basal ganglia, pain processing, analgesia, chronic pain, acute pain, pain modulation, emotional response to pain
- MeSH terms
- Analgesia, Basal Ganglia, Humans, Models, Biological, Pain
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