Psychiatric comorbidities in Asperger syndrome and high functioning autism: diagnostic challenges
Open accessAbstract
Several psychiatric conditions, both internalizing and externalizing, have been documented in comorbidity with Asperger Syndrome (AS) and High Functioning Autism (HFA). In this review we examine the interplay between psychiatric comorbidities and AS/HFA. In particular, we will focus our attention on three main issues. First, we examine which psychiatric disorders are more frequently associated with AS/HFA. Second, we review which diagnostic tools are currently available for clinicians to investigate and diagnose the associated psychiatric disorders in individuals with AS/HFA. Third, we discuss the challenges that clinicians and researchers face in trying to determine whether the psychiatric symptoms are phenotypic manifestations of AS/HFA or rather they are the expression of a distinct, though comorbid, disorder. We will also consider the role played by the environment in the manifestation and interpretation of these symptoms. Finally, we will propose some strategies to try to address these issues, and we will discuss therapeutic implications.
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The most frequent and relevant comorbidities are stress-related disorders, such as depression or anxiety.
“The most frequent and relevant ones are stress-related disorders, such as depression or anxiety (87).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [87]
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References 96 · Cited by 213
- Authors
- Mazzone, L., Ruta, L., & Reale, L.
- Affiliations
- Bambino Gesù Children's Hospital (IT)
- University of Cambridge (GB)
- University of Catania (IT)
- Corresponding author
- Mazzone, Luigi
- Venue
- Annals of General Psychiatry
- Published
- 2012
- Volume
- 11
- Issue
- 1
- Pages
- 16
- ISSN
- 1744-859X (ISSN-L)
- PMC
- PMC3416662
- OpenAlex
- W2111804634
- Cited by
- 213
- References
- 96
- Citations by year
- 2026: 1 · 2025: 14 · 2024: 12 · 2023: 14 · 2022: 15 · 2021: 11 · 2020: 22 · 2019: 18 · 2018: 15 · 2017: 14 · 2016: 17 · 2015: 28 · 2014: 20 · 2013: 10 · 2012: 1
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Annals of General Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Asperger syndrome, high-functioning autism, psychiatric comorbidity, internalizing disorders, externalizing disorders, diagnostic tools, differential diagnosis, environmental factors, treatment options
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