Efficacy of atomoxetine in adult attention-Deficit/Hyperactivity Disorder: a drug-placebo response curve analysis
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Background: The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit/hyperactivity disorder (ADHD) among adults by using drug-placebo response curve methods. Methods: We analyzed data from two double-blind, placebo-controlled, parallel design studies of adult patients (Study I, N = 280; Study II, N = 256) with DSM-IV-defined ADHD who were recruited by referral and advertising. Subjects were randomized to 10 weeks of treatment with atomoxetine or placebo, and were assessed with the Conners Adult ADHD Rating Scales and the Clinical Global Impression of ADHD Severity scale before and after treatment. Results: Those treated with atomoxetine were more likely to show a reduction in ADHD symptoms than those receiving placebo. Across all measures, the likelihood that an atomoxetine-treated subject improved to a greater extent than a placebo-treated subject was approximately 0.60. Furthermore, atomoxetine prevented worsening of most symptom classes. Conclusion: From these findings, we conclude that atomoxetine is an effective treatment for ADHD among adults when evaluated using several criteria.
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Atomoxetine has an effect size of around 0.4 in adults.
“Atomoxetine has an effect size of around 0.4 in adults [32,293]”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [293]
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References 14 · Cited by 108
- Authors
- Faraone, S. V., Biederman, J., Spencer, T., Michelson, D., Adler, L., Reimherr, F., & Glatt, S. J.
- Affiliations
- SUNY Upstate Medical University (US)
- Harvard University (US)
- Eli Lilly (United States) (US)
- New York University (US)
- University of Utah (US)
- University of California San Diego (US)
- Corresponding author
- Faraone, Stephen V
- ORCID
- Venue
- Behavioral and Brain Functions
- Published
- 2005-10-03
- Volume
- 1
- Issue
- 1
- Pages
- 16-16
- ISSN
- 1744-9081 (ISSN-L)
- PMC
- PMC1262689
- OpenAlex
- W2129135494
- Cited by
- 108
- References
- 14
- Citations by year
- 2025: 2 · 2024: 3 · 2021: 1 · 2020: 44 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Behavioral and Brain Functions (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- atomoxetine, adult ADHD, norepinephrine transporter inhibitor, treatment efficacy, symptom relief, Conners' Adult ADHD Rating Scale
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