The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy
Open accessAbstract
BACKGROUND: This trial aims at testing the efficacy of weekly reminder and motivational text messages, compared to usual care in improving adherence to Highly Active Antiretroviral Treatment in patients attending a clinic in Yaoundé, Cameroon. METHODS AND DESIGN: This is a single-centered randomized controlled single-blinded trial. A central computer generated randomization list will be generated using random block sizes. Allocation will be determined by sequentially numbered sealed opaque envelopes. 198 participants will either receive the mobile phone text message or usual care. Our hypothesis is that weekly motivational text messages can improve adherence to Highly Active Antiretroviral Treatment and other clinical outcomes in the control group by acting as a reminder, a cue to action and opening communication channels. Data will be collected at baseline, three months and six months. A blinded program secretary will send out text messages and record delivery.Our primary outcomes are adherence measured by the visual analogue scale, self report, and pharmacy refill data. Our secondary outcomes are clinical: weight, body mass index, opportunistic infections, all cause mortality and retention; biological: Cluster Designation 4 count and viral load; and quality of life. Analysis will be by intention-to-treat. Covariates and subgroups will be taken into account. DISCUSSION: This trial investigates the potential of SMS motivational reminders to improve adherence to Highly Active Antiretroviral Treatment in Cameroon. The intervention targets non-adherence due to forgetfulness and other forms of non-adherence. TRIAL REGISTRATION: Pan-African Clinical Trials Registry PACTR201011000261458 http://clinicaltrials.gov/NCT01247181.
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Understanding causal mechanisms is particularly relevant for complex interventions such as mHealth interventions, which are implemented in vastly different healthcare settings, use various functions of mobile phones, target widely different health conditions, and are used by persons with different backgrounds, behaviors, skills, and beliefs.
“Understanding these mechanisms is particularly relevant for complex interventions, such as mHealth interventions, which are implemented in vastly different healthcare settings (varying from rural communities [13, 14] to major university hospitals [15]), use various functions of mobile phones (from text messaging [16–18] to picture transmission [19]), target widely different health conditions (from”
From A realist review of mobile phone-based health interventions for non-communicable disease management in sub-Saharan Africa (2017) · cites this paper as [15]
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References 37 · Cited by 66
Research works printed but not linked: 1
- Mosoko JJ Akam W Weidle PJ Brooks JT Aweh AJ Ebad M Kinge TN Vitek C Raghunathan PL Survival and adherence to antiretroviral therapy in an era of decreasing drug cost in Limbe, Cameroon Proceedings of the 14th Conference on Retroviruses and Opportunistic Infections (CROI): 25-28 February 2007; Los Angeles, California. Abstract 536 http://www.retroconference.org/2007/ (Accessed 28 July 2010)
- Authors
- Mbuagbaw, L., Thabane, L., Ongolo-Zogo, P., Lester, R. T., Mills, E., Volmink, J., Yondo, D., Essi, M. J., Bonono-Momnougui, R.-C., Mba, R., Ndongo, J. S., Nkoa, F. C., & Ondoa, H. A.
- Affiliations
- Central Hospital of Yaoundé (CM)
- University of British Columbia (CA)
- University of Ottawa (CA)
- Stellenbosch University (ZA)
- Corresponding author
- Mbuagbaw, Lawrence
- Venue
- Trials
- Published
- 2011-01-07
- Volume
- 12
- Issue
- 1
- Pages
- 5-5
- ISSN
- 1745-6215 (ISSN-L)
- PMC
- PMC3023676
- OpenAlex
- W2155053098
- Cited by
- 66
- References
- 37
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 8 · 2012: 9
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Trials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- cIRcle (University of British Columbia) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- SUNScholar (Stellenbosch University) (submittedVersion)
- Open Collections
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Keywords
- text messaging, medication adherence, highly active antiretroviral therapy, HIV, SMS reminders, retention in care, viral load, CD4 count, opportunistic infections, quality of life, Cameroon
- MeSH terms
- Cameroon, Counseling, House Calls, Humans, Health Knowledge, Attitudes, Practice, Motivation, Quality of Life, Research Design, Time Factors, HIV Infections, Single-Blind Method, Treatment Outcome, Reminder Systems, CD4 Lymphocyte Count, Anti-HIV Agents, Viral Load, Antiretroviral Therapy, Highly Active, Cell Phone, Medication Adherence
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