A reinvestigation of recruitment to randomised, controlled, multicenter trials: a review of trials funded by two UK funding agencies

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-18 · Cited by 13,371

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

Schulz, K. F., Altman, D. G., Moher, D., & for the CONSORT Group (2010) · BMJ · doi:10.1136/bmj.c332 · Cited by 9,329

What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies

McDonald, A. M., Knight, R. C., Campbell, M. K., Entwistle, V. A., Grant, A. M., Cook, J. A., Elbourne, D. R., Francis, D., Garcia, J., Roberts, I., et al. (2006) · Trials · doi:10.1186/1745-6215-7-9 · Cited by 946

Statistics and ethics in medical research: III How large a sample?

Altman, D. G. (1980) · BMJ · doi:10.1136/bmj.281.6251.1336 · Cited by 581

Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design

Relton, C., Torgerson, D. J., O’Cathain, A., & Nicholl, J. P. (2010) · BMJ · doi:10.1136/bmj.c1066 · Cited by 519

Strategies to improve recruitment to randomised controlled trials

Treweek, S., Mitchell, E., Pitkethly, M., Cook, J., Kjeldstrøm, M., Johansen, M., Taskila, T. K., Sullivan, F., Wilson, S., Jackson, C., et al. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000013.pub5 · Cited by 378

Increasing recruitment to randomised trials: a review of randomised controlled trials

Watson, J. M., & Torgerson, D. J. (2006) · BMC Medical Research Methodology · doi:10.1186/1471-2288-6-34 · Cited by 333

Sample Sizes for Clinical Trials

Julious, S. (2009) · Chapman & Hall/CRC eBooks · doi:10.1201/9781584887409 · Cited by 102

The advantages and disadvantages of adaptive designs for clinical trials

Bauer, P., & Brannath, W. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03023-5 · Cited by 59

Recruitment to multicentre trials

Gates, S., Brocklehurst, P., Campbell, M., & Elbourne, D. R. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2004.00011.x · Cited by 30

Developing skills of allied health professionals for a principal investigator role: A case from the SIP SMART2 swallowing prehabilitation trial

Cook, F., Nazareth, I., & Govender, R. (2023) · Advances in Communication and Swallowing · doi:10.3233/acs-220021 · Cited by 1

Teilnahme an einer klinischen Studie – Ist das etwas für mich?

Lorenz, K., Böhringer, D., Wilhelm, B., Studienzentren, A. D. K., Aisenbrey, S., Allgeier, K., Baur, I. D., Bertelmann, E., Brinkmann, C. K., Choritz, L., et al. (2023) · Die Ophthalmologie · doi:10.1007/s00347-023-01845-1 · Cited by 1

A cognitive‐behavioural psychoeducation intervention on childhood anxiety for school staff: A quantitative feasibility study

Nicola, E., Mastroyannopoulou, K., & Pass, L. (2024) · Psychology in the Schools · doi:10.1002/pits.23287 · Cited by 2

Consent to recontact for future research using linked primary healthcare data: Outcomes and general practice perceptions from the ATHENA COVID-19 study

Greaves, K., King, A., Bourne, Z., Welsh, J., Morgan, M. A. J., Tolosa, M. X., Johnston, T. C., Bonner, C., Stanton, T., & Korda, R. (2024) · Clinical Trials · doi:10.1177/17407745241304094 · Cited by 1

Surgical wounds healing by Secondary Intention-2 Trial: outcomes and learning from the internal pilot phase and main trial

Arundel, C., Zahra, S., Chetter, I. C., on behalf of the SWHSI-2 Trial Investigators, Baird, K., Martin, B. C., Hewitt, C., Fairhurst, C., Gkekas, A., Mott, A., et al. (2025) · Pilot and Feasibility Studies · doi:10.1186/s40814-025-01658-w · Cited by 1

Managing Expectations in the Transition to Proof of Concept Studies

Kieber‐Emmons, T., Makhoul, I., Pennisi, A., Siegel, E. R., Emanuel, P. D., Monzavi-Karbassi, B., Steplewski, Z., Beck, J. T., & Hutchins, L. F. (2017) · Reviews on Recent Clinical Trials · doi:10.2174/1574887112666170321121250 · Cited by 1

Cultural Humility: A Collaborative Approach to Recruiting Patients with Deliberate Self-Harm into a Multi-Hospital Randomized Controlled Trial

Brownhill, S., Stevens, G. J., Hammond, T. E., Baldacchino, R., Maposa, R., Makoni, B., Sheb'a, A., Andepalli, J., Kotak, A., D'Souza, O., et al. (2021) · Journal of MultiDisciplinary Evaluation · doi:10.56645/jmde.v17i39.665 · Cited by 1

Keeping track of all ongoing colorectal cancer trials using a mobile application: Usability and satisfaction results of the Dutch Colorectal Cancer Group Trials application

Huiskens, J., Gałek-Aldridge, M. S., Bakker, J.-M., Olthof, P. B., van Gulik, T. M., Punt, C. J. A., & van Oijen, M. G. H. (2018) · Journal of Clinical and Translational Research · doi:10.18053/jctres.03.2017s3.007 · Cited by 1

Improving recruitment to a study of telehealth management for COPD: a cluster randomised controlled study-within-a-trial (SWAT) of a multimedia information resourcePreprint

Jolly, K. B., Sidhu, M. S., Madurasinghe, V., & Bower, P. (2019) · Research Square · doi:10.21203/rs.2.325/v1 · Cited by 1

Dangerous Ideas: SAPC competition winner!

Knowles, S. E. (2016) · British Journal of General Practice · doi:10.3399/bjgp16x684601

Studying the willingness to participate in acute stroke research trials

McCormack, J. (2016) · University of Birmingham Institutional Research Archive (University of Birmingham)

Reducing cardiovascular risk in chronic kidney disease : a focus on mineralocorticoid receptor antagonist and arterial stiffness in primary care

Ng, K. P. (2016) · University of Birmingham Institutional Research Archive (University of Birmingham)

Reason Analysis for Suspension/Early Termination of Drug Clinical Trial

Liufu, Y., Chen, Y., Zhang, Y., Wang, R., Liu, S., & Cheng, G. (2017) · Journal of Pharmaceutical and Biomedical Sciences

Muscle, fat and performance during androgen deprivation for prostate cancerPreprint

Owen, P. J. (2018) · Thesis Commons (OSF Preprints) · doi:10.31237/osf.io/xthkv

Strategies for recruiting participants into randomized controlled trials: A cross-program profile of the PROMISE demonstration program

Gold, P. B., Crane, K. T., Fabian, E. S., & Morris, T. R. (2019) · Journal of Vocational Rehabilitation · doi:10.3233/jvr-191042

Improve Statistical Reporting Forms in Research Institutions of the Health Ministry of Russia

Lebedev, G. S., Krylov, O., Yuriy, A., Mironov, Y., Tkachenko, V., Fartushniy, E., & Zykov, S. V. (2020) · Smart innovation, systems and technologies · doi:10.1007/978-981-15-5925-9_36

Efficient identification of patients eligible for clinical studies using case-based reasoning on Scottish Health Research Register (SHARE).Preprint

Shi, W., Kelsey, T., & Sullivan, F. (2020) · Research Square · doi:10.21203/rs.2.18160/v2

The challenges of alcohol addictions randomised control trials (RCTs): A nominal group technique (NGT) analysisPreprint

Brobbin, E., Dunne, J., Hermann, L. L., Kimergård, A., & Donoghue, K. (2021) · Research Square · doi:10.21203/rs.3.rs-432672/v1

App-based treatment for female urinary incontinence

Loohuis, A. M. M. (2021) · doi:10.33612/diss.182829039

A systematic review of the application of machine learning methods for patient recruitment through electronic health records (Preprint)Preprint

Shi, W., Moffat, K., Kelsey, T., & Sullivan, F. (2021) · doi:10.2196/preprints.30140

Strategies for improving recruitment of pregnant women to clinical research: An evaluation of social media versus traditional offline methods in Vancouver, Canada (Preprint)Preprint

Cochrane, K. M., Hutcheon, J. A., & Karakochuk, C. D. (2021) · doi:10.2196/preprints.29377

Recruitment, Recruitment, Recruitment – But Do We Collect and Report All The Information We Should? A Retrospective Review of Ovarian Cancer Trials in A 10-Year PeriodPreprint

Greene, E. R. O., & Shiely, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1121888/v1

Improving recruitment to a study of telehealth management for COPD: a cluster randomised controlled study-within-a-trial (SWAT) of a multimedia information resourcePreprint

Jolly, K. B., Sidhu, M. S., Madurasinghe, V., & Bower, P. (2019) · Research Square · doi:10.21203/rs.2.325/v2 · Cited by 1

Testing the effectiveness of an animated decision aid to improve recruitment of control participants in a case-control study: An online experiment (Preprint)Preprint

Stoffel, S., Law, J. H., Kerrison, R., Brewer, H. R., Flanagan, J. M., & Hirst, Y. (2022) · doi:10.2196/preprints.40015

Relational autonomy in clinical research: Relational considerations of adult participation in clinical research

Pieper, I. J. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.231386

Efficient identification of patients eligible for clinical studies using case-based reasoning on Scottish Health Research Register (SHARE).Preprint

Shi, W., Kelsey, T., & Sullivan, F. (2020) · Research Square · doi:10.21203/rs.2.18160/v3

Efficient identification of patients eligible for clinical studies using case-based reasoning on Scottish Health Research Register (SHARE).Preprint

Shi, W., Kelsey, T., & Sullivan, F. (2019) · Research Square · doi:10.21203/rs.2.18160/v1

Ausbau des Probandenmanagementsystems der Universitätsmedizin Göttingen für standortübergreifende Kooperationen in der klinischen Forschung

Pung, J. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9373

A photograph of the researcher on the invitation letter did not affect the participation rate of a postal survey: a randomized study within a trial (SWAT)

Prediger, B., Könsgen, N., Bora, A.-M., Schlimbach, A., & Pieper, D. (2022) · BMC Medical Research Methodology · doi:10.1186/s12874-022-01717-3

A case against social networks as the only means for recruitment in scientific studies with humansPreprint

Pastor, A. (2022) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/84utm

How to Keep Your (Stroke) Trial Alive?

Arnold, M., Kaesmacher, J., & Mira, K. (2023) · Stroke · doi:10.1161/strokeaha.122.037784

Research operations management

Lanerolle, G. D., Phiri, P., & Haroon, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821787-0.00014-3

‘Just one interview’: making visible the hidden workload associated with qualitative research

Menzies, J. C., Tooke, C., Jones, T. J. J., Lavis, A., & Drury, N. E. (2023) · Nurse Researcher · doi:10.7748/nr.2023.e1872

Implementation of inclusion and exclusion criteria of clinical studies in the software OHDSI ATLASPreprint

Blasini, R., Buchowicz, K. M., Schneider, H., Samans, B., & Sohrabi, K. (2023) · Research Square · doi:10.21203/rs.3.rs-2985787/v1

Discrepancies of Abstracts Presented in Coloproctology Congresses and Later Publish as Full Manuscripts. A Brazilian Perspective

Samartine, H., Levy, N., Paiva, D. F., Gracitelli, G. B., Silva, L. I., de Aquino, J. L. B., & Mendes, E. T. (2023) · Journal of Coloproctology · doi:10.1055/s-0043-1772783

Construire une étude en traumatologie ostéoarticulaire

Rouleau, D. M. (2017) · Elsevier eBooks · doi:10.1016/b978-2-294-75673-3.00001-x

Patients’ experiences of clinical trial participation involving a product remotely assessing study drug adherence

Henriksson, C., Olsson, A., Andersen, K., Arefalk, G., Erlinge, D., Hofmann, R., Ridderstråle, W., Rutgersson, A., Oldgren, J., & James, S. K. (2024) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2024.101307

Digitale Technik für ambulante Pflege und Therapie III

Weber, K., Haug, S., Lauer, N., Mohr, C., Pfingsten, A., Raptis, G., & Bahr, G. (2024) · Regensburger Beiträge zur Digitalisierung des Gesundheitswesens · doi:10.14361/9783839467282

Advancements in Clinical Research: Phases, Ethical Considerations, and Technological Innovations

Ashish, P. (2024) · Archives of Case Reports · doi:10.29328/journal.acr.1001102

Using data to enable growth of research capability and capacity: a retrospective longitudinal analysis of gastroenterology and hepatology research participation across secondary and tertiary healthcare settings within England

Kumar, A., Peerally, M. F., Saifuddin, A., Bancil, A. S., Ryan, P. M., Iqbal, T. H., Corless, L., Segal, J. P., & Brookes, M. (2025) · Frontline Gastroenterology · doi:10.1136/flgastro-2024-103038

Randomized Clinical Trials in Cerebrovascular Neurosurgery: Analysis of Discontinuation and Nonpublication Prevalence and Trends

Butler, M., Kaoutzani, L., & Rahimi, S. Y. (2025) · World Neurosurgery · doi:10.1016/j.wneu.2025.124159

Process Evaluation of a Randomized Controlled Trial With a Mobile Health Intervention for Children With Obesity

Hedin, L., Hagströmer, M., Marcus, C., & Danielsson, P. (2025) · Sage Open Pediatrics · doi:10.1177/30502225251348292

Facilitators and Barriers to Recruitment and Engagement with a Randomised Controlled Trial in Mental Health Services: experiences of trial participants and intervention providersPreprint

Naughton, G., Lloyd‐Evans, B., Billings, J., Gray, H., Ambler, G., Barber, N., Chipp, B., Clare, J., Conneely, M., Evlat, G., et al. (2025) · medRxiv · doi:10.1101/2025.10.08.25337563

PENTAGON (Predicting Clinical Trials in Gynecologic Oncology): A Retrospective Study Assessing Study Design Factors That Affect Enrollment in Gynecologic Cancer Trials

Klein, M., Pirzadah, H. A., Magharehabed, Y., Hall, L., Chapple, A. G., Nair, N., Castellano, T., & Jernigan, A. M. (2025) · Cancers · doi:10.3390/cancers17233774

A Bayesian model with seasonal effects for predicting accrual in clinical trials: Application to HOBIT and BOOST-3 trials for severe traumatic brain injury

Rahman, M. M., Saif, M. S. I., Beall, J., Martin, R. H., Rockswold, G. L., Barsan, W. G., Korley, F. K., Silbergleit, R., Stevenson, V., & Gajewski, B. J. (2025) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2025.101586

Additional file 1 of Is health research undertaken where the burden of disease is greatest? Observational study of geographical inequalities in recruitment to research in England 2013–2018

Bower, P., Grigoroglou, C., Anselmi, L., Kontopantelis, E., Sutton, M., Ashworth, M., Evans, P., Lock, S., Smye, S. W., & Abel, K. M. (2020) · Figshare · doi:10.6084/m9.figshare.12319019

Additional file 5 of A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment

Applequist, J., Burroughs, C., Ramirez, A., Merkel, P. A., Rothenberg, M. E., Trapnell, B., Desnick, R. J., Sahin, M., & Krischer, J. P. (2020) · Figshare · doi:10.6084/m9.figshare.11984565

Additional file 2 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376206

Additional file 2 of What do stroke survivors’ value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey

Weerasekara, I., Baye, J., Burke, M., Crowfoot, G., Mason, G., Peak, R., Simpson, D., Walker, F. R., Nilsson, M., Pollack, M. R. P., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16780833

Additional file 2 of The development and acceptability of an educational and training intervention for recruiters to neonatal trials: the TRAIN project

Smith, V., Delaney, H., Hunter, A., Torgerson, D., Treweek, S., Gamble, C. L., Mills, N., Stanbury, K., Dempsey, E., Daly, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26638578

Additional file 2 of Enrollment, retention, and strategies for including disadvantaged populations in randomized controlled trials: a systematic review protocol

LaPlante, A., Yen, R. W., Isaacs, T., Crocker, J. C., Demjén, Z., Schubbe, D. C., Kennedy, A. M., Engel, J., O’Brien, N., Richters, C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15253839

Additional file 3 of What do stroke survivors’ value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey

Weerasekara, I., Baye, J., Burke, M., Crowfoot, G., Mason, G., Peak, R., Simpson, D. B., Walker, F. R., Nilsson, M., Pollack, M. R. P., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16780836

Additional file 1 of Development of a new adapted QuinteT Recruitment Intervention (QRI-Two) for rapid application to RCTs underway with enrolment shortfalls—to identify previously hidden barriers and improve recruitment

Donovan, J., Jepson, M., Rooshenas, L., Paramasivan, S., Mills, N., Elliott, D., Wade, J., Reda, D., Blazeby, J. M., Moghanaki, D. M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19518339

Additional file 2 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616204

Additional file 2 of Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets

Madurasinghe, V., Bower, P., Eldridge, S., Collier, D., Graffy, J., Treweek, S., Knapp, P., Parker, A., Rick, J., Salisbury, C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16664473

Additional file 4 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376212

Additional file 1 of Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!

Lewis, M., Bromley, K., Sutton, C., McCray, G., Myers, H. L., & Lancaster, G. A. (2021) · Figshare · doi:10.6084/m9.figshare.13710841

Additional file 1 of Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs)

Madurasinghe, V., Knapp, P., Eldridge, S. M., Collier, D., Treweek, S., Rick, J., Graffy, J., Parker, A., Salisbury, C., Torgerson, D. J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24531977

Additional file 7 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376221

Additional file 1 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616201

Additional file 3 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376209

Additional file 3 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616207

Additional file 3 of A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment

Applequist, J., Burroughs, C., Ramirez, A., Merkel, P. A., Rothenberg, M. E., Trapnell, B., Desnick, R. J., Sahin, M., & Krischer, J. P. (2020) · Figshare · doi:10.6084/m9.figshare.11984553

Additional file 1 of Early experience with an opt-in research register - Scottish Health Research Register (SHARE): a multi-method evaluation of participant recruitment performance

Shi, W., Vasishta, S., Dow, L., Cavellini, D., Palmer, C., McKinstry, B., & Sullivan, F. (2021) · Figshare · doi:10.6084/m9.figshare.17305401

Additional file 1 of Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets

Madurasinghe, V., Bower, P., Eldridge, S. M., Collier, D., Graffy, J., Treweek, S., Knapp, P., Parker, A., Rick, J., Salisbury, C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16664470

Additional file 3 of The development and acceptability of an educational and training intervention for recruiters to neonatal trials: the TRAIN project

Smith, V. A., Delaney, H., Hunter, A., Torgerson, D., Treweek, S., Gamble, C. L., Mills, N., Stanbury, K., Dempsey, E., Daly, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26638581

Additional file 1 of Hematologists’ barriers and enablers to screening and recruiting patients to a chimeric antigen receptor (CAR) T cell therapy trial: a theory-informed interview study

Castillo, G., Lalu, M., Asad, S. S., Foster, M., Kekre, N. K., Fergusson, D. A., Hawrysh, T., Atkins, H., Thavorn, K., Montroy, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14313463

Additional file 2 of Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs)

Madurasinghe, V., Knapp, P., Eldridge, S. M., Collier, D., Treweek, S., Rick, J., Graffy, J., Parker, A., Salisbury, C., Torgerson, D. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24532280

Additional file 1 of A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment

Applequist, J., Burroughs, C., Ramirez, A., Merkel, P. A., Rothenberg, M. E., Trapnell, B., Desnick, R. J., Sahin, M., & Krischer, J. P. (2020) · Figshare · doi:10.6084/m9.figshare.11984547

Additional file 1 of The development and acceptability of an educational and training intervention for recruiters to neonatal trials: the TRAIN project

Smith, V. A., Delaney, H., Hunter, A., Torgerson, D., Treweek, S., Gamble, C. L., Mills, N., Stanbury, K., Dempsey, E., Daly, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26638575

Additional file 1 of Enrollment, retention, and strategies for including disadvantaged populations in randomized controlled trials: a systematic review protocol

LaPlante, A., Yen, R. W., Isaacs, T., Crocker, J. C., Demjén, Z., Schubbe, D. C., Kennedy, A. M., Engel, J., O’Brien, N., Richters, C., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15253836

Additional file 1 of What do stroke survivors’ value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey

Weerasekara, I., Baye, J., Burke, M., Crowfoot, G., Mason, G., Peak, R., Simpson, D. B., Walker, F. R., Nilsson, M., Pollack, M. R. P., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16780830

Additional file 3 of Hematologists’ barriers and enablers to screening and recruiting patients to a chimeric antigen receptor (CAR) T cell therapy trial: a theory-informed interview study

Castillo, G., Lalu, M., Asad, S., Foster, M., Kekre, N. K., Fergusson, D. A., Hawrysh, T., Atkins, H., Thavorn, K., Montroy, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14313469

Additional file 1 of Reflections on the challenges of conducting an international multicentre randomized controlled trial of balance training in addition to pulmonary rehabilitation and its impact on fall incidence in people with COPD

Newman, A. N. L., Beauchamp, M. K., Ellerton, C., Goldstein, R., Alison, J. A., Dechman, G., Haines, K. J., Harrison, S. L., Holland, A. E., Lee, A. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26322651

Additional file 3 of Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of ‘studies within a trial’ (SWATs)

Madurasinghe, V., Knapp, P., Eldridge, S. M., Collier, D., Treweek, S., Rick, J., Graffy, J., Parker, A., Salisbury, C., Torgerson, D. J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26637408

Additional file 1 of Challenges in recruiting and retaining adolescents with abuse-related posttraumatic stress disorder: lessons learned from a randomized controlled trial

Vogel, A., Comteße, H., & Rosner, R. (2020) · Figshare · doi:10.6084/m9.figshare.12144618

Additional file 5 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376215

Additional file 1 of Recruiting hard-to-reach pregnant women at high psychosocial risk: strategies and costs from a randomised controlled trial

MacLachlan, A., Crawford, K., Shinwell, S., Nixon, C., & Henderson, M. (2021) · Figshare · doi:10.6084/m9.figshare.14795200

Additional file 1 of A photograph of the researcher on the invitation letter did not affect the participation rate of a postal survey: a randomized study within a trial (SWAT)

Prediger, B., Könsgen, N., Bora, A.-M., Schlimbach, A., & Pieper, D. (2022) · Figshare · doi:10.6084/m9.figshare.21203235

Additional file 1 of Participants’ perspectives of being recruited into a randomised trial of a weight loss intervention before colorectal cancer surgery: a qualitative interview study

Talbot, A., Jebb, S. A., Foster, C., Realpe, A. X., Wheatstone, P., Buczacki, S. J. A., & Koutoukidis, D. A. (2024) · Figshare · doi:10.6084/m9.figshare.26743562

Additional file 4 of A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment

Applequist, J., Burroughs, C., Ramirez, A., Merkel, P. A., Rothenberg, M. E., Trapnell, B., Desnick, R. J., Sahin, M., & Krischer, J. P. (2020) · Figshare · doi:10.6084/m9.figshare.11984556

Additional file 6 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376218

Additional file 2 of A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment

Applequist, J., Burroughs, C., Ramirez, A., Merkel, P. A., Rothenberg, M. E., Trapnell, B., Desnick, R. J., Sahin, M., & Krischer, J. P. (2020) · Figshare · doi:10.6084/m9.figshare.11984550

Additional file 2 of Challenges in recruiting and retaining adolescents with abuse-related posttraumatic stress disorder: lessons learned from a randomized controlled trial

Vogel, A., Comteße, H., & Rosner, R. (2020) · Figshare · doi:10.6084/m9.figshare.12144624

Additional file 5 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616213

Additional file 8 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616222

Additional file 1 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376203

Additional file 4 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616210

Additional file 7 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616219

Additional file 8 of Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis

Farrar, N., Elliott, D., Houghton, C., Jepson, M., Mills, N., Paramasivan, S., Plumb, L., Wade, J., Young, B., Donovan, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21376224

Additional file 1 of Generalizability and reach of a randomized controlled trial to improve oral health among home care recipients: comparing participants and nonparticipants at baseline and during follow-up

Czwikla, J., Herzberg, A., Kapp, S., Kloep, S., Rothgang, H., Nitschke, I., Haffner, C., & Hoffmann, F. (2022) · Figshare · doi:10.6084/m9.figshare.20279281

Additional file 6 of Factors associated with recruitment to randomised controlled trials in general practice: a systematic mixed studies review

Moffat, K. R., Shi, W., Cannon, P., & Sullivan, F. (2023) · Figshare · doi:10.6084/m9.figshare.22616216

Trends in the design quality of randomized clinical trials on acupotomy over the past 21 years and influencing factors: a CONSORT-based systematic review from 2003 to 2024

Li, J.-J., Xue, D.-M., Zhou, Y.-T., Lu, X.-Z., & Bian, Y. (2025) · Evidence-Based Chinese Medicine and Technology Assessment · doi:10.26599/ecmta.2025.9570017

A randomised Study Within a Trial (SWAT) to determine if participant information leaflet design affects recruitment rate into an interventional trial taking place in a UK emergency department

Sherman, R., Tabner, A. J., Fakis, A., Parker, A., & Johnson, G. (2026) · Trials · doi:10.1186/s13063-025-09412-6

Laparoscopic hysterectomy versus open abdominal hysterectomy for women with a benign gynaecological condition: the LAVA RCT

Clark, T. J., Antoun, L., Woolley, R. L., Bevan, S., Ziomek, K., McKinnon, W., Smith, P., Cooper, K. G., Sarıdoğan, E., Sairally, B. Z. F., et al. (2025) · Health Technology Assessment · doi:10.3310/gjtc1718 · Cited by 1

Protocol for Standardized Single-Session Cardiopulmonary Exercise Test for Measuring Peak Oxygen Uptake, Oxygen On/Off Kinetics, and Skeletal Muscle Oxygenation in ICU survivors: ICU Combined Assessment of Cardio-Respiratory Exercise (ICU-CARE) Study (Preprint)Preprint

Blunderfield, B., de SANTANA, J. S., Majumdar, R., Herath, I. S., Blouw, M., Ramsey, C., Olafson, K., Sousa, M. L. D. A., Boyd, J. G., Rozenberg, D., et al. (2026) · doi:10.2196/preprints.92346

Brief psychological intervention for the prevention of deliberate self-poisoning: A randomized controlled trial from Sri Lanka

Silva, L. D., Kidger, J., Tennakoon, S., Dawson, A. H., Gawarammana, I., & Rajapakse, T. N. (2026) · PLOS mental health. · doi:10.1371/journal.pmen.0000562

Association of Protocol Design‐Related Factors With Enrollment Duration in Clinical Trials

Tsuchiya, H., Sekine, M., Nishizaki, Y., Hida, N., Sambe, T., Sanada, S., & Naito, T. (2026) · Clinical and Translational Science · doi:10.1111/cts.70529

Intérêt d'une approche de type "méta-analyse prospective d'essais de taille fixe" dans l'évaluation thérapeutique

Tavernier, E. (2016) · theses.fr (ABES) · doi:10.70675/dc94d400ze0b4z4d1fzbb24z29bfd936144b

Recruitment strategies and participant motivations in a digital randomized controlled trial for the prevention of anxiety disorders: the prevANS study

García-Huércano, C., Cerón, S. C., Morejón, A. R., Martínez-Vispo, C., Sánchez‐Aguadero, N., Tamayo‐Morales, O., & Moreno-Peral, P. (2026) · Frontiers in Digital Health · doi:10.3389/fdgth.2026.1746430

What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies

McDonald, A. M., Knight, R. C., Campbell, M. K., Entwistle, V. A., Grant, A. M., Cook, J. A., Elbourne, D. R., Francis, D., Garcia, J., Roberts, I., et al. (2006) · Trials · doi:10.1186/1745-6215-7-9 · Cited by 946

Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology Assessment Programme

Walters, S. J., Bonacho dos Anjos Henriques-Cadby, I., Bortolami, O., Flight, L., Hind, D., Jacques, R. M., Knox, C., Nadin, B., Rothwell, J., Surtees, M., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015276 · Cited by 560

Recruitment, consent and retention of participants in randomised controlled trials: a review of trials published in the National Institute for Health Research (NIHR) Journals Library (1997–2020)

Jacques, R. M., Ahmed, R., Harper, J., Ranjan, A., Saeed, I., Simpson, R. M., & Walters, S. J. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059230 · Cited by 120

METHODOLOGY Open Access Meeting the challenges of b n Be Background of trials recruiting to target [2,3]. This may result in an TRIALS

(2016)

Do NIHR health technology assessment randomised clinical trials perform as well as expected?

Young, A., Raftery, J., Stanton, L., & Cook, A. (2013) · Trials · doi:10.1186/1745-6215-14-s1-p92