The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Hollow mesoporous silica nanoparticles for intracellular delivery of fluorescent dye
Open accessAbstract
In this study, hollow mesoporous silica nanoparticles (HMSNs) were synthesized using the sol-gel/emulsion approach and its potential application in drug delivery was assessed. The HMSNs were characterized, by transmission electron microscopy (TEM), Scanning Electron Microscopy (SEM), nitrogen adsorption/desorption and Brunauer-Emmett-Teller (BET), to have a mesoporous layer on its surface, with an average pore diameter of about 2 nm and a surface area of 880 m2/g. Fluorescein isothiocyanate (FITC) loaded into these HMSNs was used as a model platform to assess its efficacy as a drug delivery tool. Its release kinetic study revealed a sequential release of FITC from the HMSNs for over a period of one week when soaked in inorganic solution, while a burst release kinetic of the dye was observed just within a few hours of soaking in organic solution. These FITC-loaded HMSNs was also found capable to be internalized by live human cervical cancer cells (HeLa), wherein it was quickly released into the cytoplasm within a short period of time after intracellular uptake. We envision that these HMSNs, with large pores and high efficacy to adsorb chemicals such as the fluorescent dye FITC, could serve as a delivery vehicle for controlled release of chemicals administered into live cells, opening potential to a diverse range of applications including drug storage and release as well as metabolic manipulation of cells.
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Cited by
Removal of heavy metals from industrial wastewaters: a review
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Metadata
- Authors
- Guo, H., Qian, H., Sun, S., Sun, D., Yin, H., Cai, X., Liu, Z., Wu, J., Jiang, T., & Liu, X.
- Venue
- Chemistry Central Journal
- Published
- 2011-01-05
- Volume
- 5
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1752-153X (ISSN-L)
- OpenAlex
- W2129957143
- Cited by
- 299
- References
- 21
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guo, H., Qian, H., Sun, S., Sun, D., Yin, H., Cai, X., Liu, Z., Wu, J., Jiang, T., & Liu, X. (2011). Hollow mesoporous silica nanoparticles for intracellular delivery of fluorescent dye. Chemistry Central Journal. https://doi.org/10.1186/1752-153x-5-1
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