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Cited by 128Mathematical Biology Tumor GrowthNanoparticle-Based Drug DeliveryCancer Cells and Metastasis

Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors

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Sefidgar, Mostafa, Soltani, M, Raahemifar, Kaamran, Bazmara, Hossein, Nayinian, Seyed Mojtaba Mousavi, Bazargan, Majid·2014·Journal of Biological Engineering
DOI 10.1186/1754-1611-8-12PMC PMC4076317

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Abstract

BACKGROUND: The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on drug delivery to solid tumor. METHODS: The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and drug delivery are investigated. RESULTS: Sensitivity analysis shows that drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases drug concentration in interstitial fluid. This study shows that dependency of drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. CONCLUSIONS: This study shows that among diffusion and convection mechanisms of drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the drug concentration is larger than that of other tumors at the same time post injection.

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  • Tumor size and associated hypoxia levels affect the efficacy of drug delivery to the tumor.

    “recently published literature discusses the role of the size of a tumor (and the associated hypoxia levels) on its aggressiveness [81,82,83,84,85] and on the efficacy of drug delivery to it [84,86,87].”

    From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [87]

    The Abstract Results and Discussion (page not available) report that increasing tumor size reduces drug concentration in interstitial fluid, supporting the size–delivery link. They explain this through increased interstitial fluid pressure, not associated hypoxia levels; our copy does not support that part of the claim. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Sefidgar, M., Soltani, M., Raahemifar, K., Bazmara, H., Nayinian, S. M. M., & Bazargan, M.
Affiliations
  • Johns Hopkins University (US)
  • Toronto Metropolitan University (CA)
Corresponding author
Soltani, M
ORCID
Venue
Journal of Biological Engineering
Publisher
Springer Science and Business Media LLC
Published
2014-06-12
Volume
8
Issue
1
Pages
12-12
ISSN
1754-1611 (ISSN-L)
DOI
10.1186/1754-1611-8-12
PMC
PMC4076317
OpenAlex
W2137780330
Cited by
128
References
1
Citations by year
2026: 5 · 2025: 10 · 2024: 11 · 2023: 11 · 2022: 16 · 2021: 19 · 2020: 16 · 2019: 9 · 2018: 10 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 2
FWCI
6.74
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Biological Engineering (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
tumor shape, tumor size, interstitial fluid flow, solute transport, diffusion, convection, extracellular matrix, hydraulic conductivity, effective pressure, lymphatic drainage, finite volume method, sensitivity analysis

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