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Cited by 265HIV/AIDS Research and InterventionsHIV-related health complications and treatmentsHIV Research and Treatment

What determines health-related quality of life among people living with HIV: an updated review of the literature

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Degroote, Sophie, Vogelaers, Dirk, Vandijck, Dominique M·2014·Archives of Public Health
DOI 10.1186/2049-3258-72-40PMC PMC4323115
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Abstract

BACKGROUND: As infection with the Human Immunodeficiency Virus (HIV) has evolved to a chronic disease, perceived health-related quality of life (HRQoL) is becoming a prominent and important patient-reported outcome measure in HIV care. Literature discusses different factors influencing HRQoL in this population, however, currently no consensus exists about the main determinants. In this review a clear, up-to-date overview of the determinants influencing HRQOL among people living with HIV is provided. METHODS: All studies published before July 2013 that identified determinants of HRQoL among people living with HIV in high-income countries, were considered in this narrative review. PubMed, Web of Science and The Cochrane Library were consulted using the keywords 'determinants', 'quality of life', 'HIV' and 'AIDS'. To be included, studies should have reported overall health and/or physical/mental health scores on a validated instrument and performed multivariable regression analyses to identify determinants that independently influence perceived HRQoL. RESULTS: In total, 49 studies were included for further analysis and they used a variety of HRQoL instruments: Medical Outcomes Study Short Form-36 or variants, Medical Outcomes Study-HIV, HIV Cost and Services Utilization Study measure, Multidimensional Quality of Life Questionnaire, HIV targeted quality of life instrument, Functional Assessment of Human Immunodeficiency Virus Infection, HIV Overview of Problems Evaluation System, EuroQol, Fanning Quality of Life scale, Health Index and PROQOL-HIV. In this review, the discussed determinants were thematically divided into socio-demographic, clinical, psychological and behavioural factors. Employment, immunological status, presence of symptoms, depression, social support and adherence to antiretroviral therapy were most frequently and consistently reported to be associated with HRQoL among people living with HIV. CONCLUSIONS: HRQoL among people living with HIV is influenced by several determinants. These determinants independently, but simultaneously impact perceived HRQoL. Most HRQoL instruments do not capture all key determinants. We recommend that the choice for an instrument should depend on the purpose of the HRQoL assessment.

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  • Maintaining satisfactory interpersonal relationships is one of the most important factors for the quality of life of people living with HIV.

    “η διατήρηση ικανοποιητικών διαπροσωπικών σχέσεων αποτελεί έναν από τους σημαντικότερους παράγοντες για την ποιότητα ζωής των ανθρώπων που ζουν με HIV. 34,35”

    From Clinical presentation and requests for support of people with HIV/AIDS seeking counselling and psychotherapy in Greece (2019) · cites this paper as [34]

    The Results sections on psychological factors and family situation report that social support is associated with better health-related quality of life and that a stable relationship can contribute to it. They do not establish that maintaining satisfactory interpersonal relationships is one of the most important factors; the findings about partner relationships are also mixed. Page numbers are not available in our copy. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Degroote, S., Vogelaers, D., & Vandijck, D. M.
Affiliations
Ghent University Hospital (BE)
Corresponding author
Degroote, Sophie
ORCID
Venue
Archives of Public Health
Publisher
Springer Science and Business Media LLC
Published
2014-11-17
Volume
72
Issue
1
Pages
40-40
ISSN
  • 0778-7367 (ISSN-L)
  • 2049-3258
DOI
10.1186/2049-3258-72-40
PMC
PMC4323115
OpenAlex
W2166661571
Cited by
265
References
1
Citations by year
2026: 22 · 2025: 19 · 2024: 22 · 2023: 27 · 2022: 20 · 2021: 36 · 2020: 24 · 2019: 27 · 2018: 21 · 2017: 24 · 2016: 18 · 2015: 5
FWCI
11.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Archives of Public Health (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
health-related quality of life, people living with HIV, determinants of quality of life, employment, immune status, depression, social support, antiretroviral therapy adherence, HIV symptoms, patient-reported outcome measures

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