The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Specific antioxidant properties of human serum albumin
Open accessAbstract
Human serum albumin (HSA) has been used for a long time as a resuscitation fluid in critically ill patients. It is known to exert several important physiological and pharmacological functions. Among them, the antioxidant properties seem to be of paramount importance as they may be implied in the potential beneficial effects that have been observed in the critical care and hepatological settings. The specific antioxidant functions of the protein are closely related to its structure. Indeed, they are due to its multiple ligand-binding capacities and free radical-trapping properties. The HSA molecule can undergo various structural changes modifying its conformation and hence its binding properties and redox state. Such chemical modifications can occur during bioprocesses and storage conditions of the commercial HSA solutions, resulting in heterogeneous solutions for infusion. In this review, we explore the mechanisms that are responsible for the specific antioxidant properties of HSA in its native form, chemically modified forms, and commercial formulations. To conclude, we discuss the implication of this recent literature for future clinical trials using albumin as a drug and for elucidating the effects of HSA infusion in critically ill patients.
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Levitt, D., & Levitt, M. (2016) · International Journal of General Medicine · doi:10.2147/ijgm.s102819 · Cited by 763
Human serum albumin, systemic inflammation, and cirrhosis
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Serum albumin in health and disease: esterase, antioxidant, transporting and signaling properties
Belinskaia, D. A., Voronina, P. A., Shmurak, V. I., Jenkins, R. O., & Goncharov, N. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910318 · Cited by 416
RONS and Oxidative Stress: An Overview of Basic Concepts
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Metadata
- Authors
- Taverna, M., Marie, A.-L., Mira, J.-P., & Guidet, B.
- Venue
- Annals of Intensive Care
- Publisher
- Elsevier BV
- Published
- 2013
- Volume
- 3
- Issue
- 1
- Pages
- 4
- ISSN
- 2110-5820 (ISSN-L)
- OpenAlex
- W2165988110
- Cited by
- 473
- References
- 56
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Taverna, M., Marie, A.-L., Mira, J.-P., & Guidet, B. (2013). Specific antioxidant properties of human serum albumin. Annals of Intensive Care. https://doi.org/10.1186/2110-5820-3-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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