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Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis
Open accessAbstract
The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: (1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and (3) degradation; (4) phenotypic modulation of the articular chondrocytes; and (5) formation of osteophytes. In osteoarthritis, the primary responses are reinitiation of synthesis of cartilage macromolecules, the initiation of synthesis of types IIA and III procollagens as markers of a more primitive phenotype, and synthesis of active proteolytic enzymes. Reversion to a fibroblast-like phenotype, known as "dedifferentiation", does not appear to be an important component. Proliferation plays a role in forming characteristic chondrocyte clusters near the surface, while apoptosis probably occurs primarily in the calcified cartilage.
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Cited by
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179
Osteoarthritis — an untreatable disease?
Wieland, H. A., Michaelis, M., Kirschbaum, B. J., & Rudolphi, K. A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1693 · Cited by 585
Aging and osteoarthritis: Central role of the extracellular matrix
Rahmati, M., Nalesso, G., Mobasheri, A., & Mozafari, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.004 · Cited by 567
Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
Yang, S., Kim, J., Ryu, J.-H., Oh, H., Chun, C.-H., Kim, B. J., Min, B. H., & Chun, J.-S. (2010) · Nature Medicine · doi:10.1038/nm.2153 · Cited by 527
Metadata
- Authors
- Sandell, L. J., & Aigner, T.
- Venue
- Arthritis Research & Therapy
- Published
- 2001-01
- Volume
- 3
- Issue
- 2
- Pages
- 107-13
- ISSN
- 1478-6354 (ISSN-L)
- 1478-6362
- OpenAlex
- W1551310212
- Cited by
- 907
- References
- 0
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- gold
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