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Cited by 99Liver Disease and TransplantationClinical Nutrition and GastroenterologyTrauma, Hemostasis, Coagulopathy, Resuscitation

Human albumin in the management of complications of liver cirrhosis

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Bernardi, Mauro, Maggioli, Caterina, Zaccherini, Giacomo·2012·Critical Care
DOI 10.1186/cc11218PMC PMC3681351
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Abstract

Human serum albumin is the most abundant plasma protein, representing about 50% of the total protein content (3.5-5 g/l). Albumin is a protein of 585 amino acids and molecular weight 66 kDa encoded by a gene on chromosome 4 and is exclusively synthesized by liver cells, which release it directly into the blood stream without storage. Under physiological conditions, only 20-30% of hepatocytes are committed to the production of 9-12 g of albumin per day; therefore, the liver has a large functional reserve, so that it can increase the synthesis of this protein by 3-4 times, if necessary. The production of albumin is mainly regulated by the osmolarity and oncotic pressure of interstitial fluid in the liver extravascular space, but it is also induced by hormonal factors (insulin, cortisol and growth hormone) and inhibited by acute phase cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α [ 1 ].

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  • The amounts of ALBUMIN and FIBRINOGEN secreted by day-18 hPSC-derived hepatocytes were in the same order of magnitude as the amount secreted by hepatocytes in vivo in human beings.

    “Second, day-18 hPSC-derived hepatocytes secreted ALBUMIN and FIBRINOGEN proteins into the medium (5.89 ± 0.71 μg/mL and 1.38 ± 0.26 μg/mL, respectively [Figures 4G and S4L]) in the same order of magnitude as the amount secreted by hepatocytes in vivo in human beings (Bernardi et al., 2012; Tennent et al., 2007).”

    From A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells (2018) · cites this paper as Bernardi et al., 2012

    The Introduction (page not specified) gives an in-vivo human albumin production rate of 9–12 g per day and says liver cells release albumin into the bloodstream. It gives no fibrinogen secretion rate and does not establish that either in-vivo rate is in the same order of magnitude as the reported day-18 culture-medium concentrations. (LLM, conf=0.86)

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Research works printed but not linked: 36

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Authors
Bernardi, M., Maggioli, C., & Zaccherini, G.
Affiliations
  • Ospedale di Cattinara (IT)
  • IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Corresponding author
Bernardi, Mauro
ORCID
Venue
Critical Care
Publisher
Springer Science and Business Media LLC
Published
2012-03-20
Volume
16
Issue
2
Pages
211-211
ISSN
1364-8535 (ISSN-L)
DOI
10.1186/cc11218
PMC
PMC3681351
OpenAlex
W2096394150
Cited by
99
References
0
Citations by year
2026: 7 · 2025: 10 · 2024: 13 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 3
FWCI
0.76
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Critical Care (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Keywords
human serum albumin, liver cirrhosis, cirrhosis complications, albumin synthesis, hepatocyte function, colloid osmotic pressure, osmolarity, acute phase response, cytokines, albumin therapy
MeSH terms
Albumins, Humans, Liver Cirrhosis, Liver Function Tests, Serum Albumin

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