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Cited by 63Blood transfusion and managementTrauma, Hemostasis, Coagulopathy, ResuscitationBlood donation and transfusion practices

Optimizing the use of blood products in trauma care.

Open access
John R. Hess, Seppo T. Hiippala·2005·Critical Care
DOI 10.1186/cc3780PMC PMC3226118
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Abstract

Blood transfusion has been used to treat the injured since the US Civil War. Now, it saves the lives of tens of thousands of injured patients each year. However, not everyone who receives blood benefits, and some recipients are injured by the transfusion itself. Effective blood therapy in trauma management requires an integration of information from diverse sources, including data relating to trauma and blood use epidemiology, medical systems management, and clinical care. Issues of current clinical concern in highly developed trauma systems include how to manage massive transfusion events, how to limit blood use and so minimize exposure to transfusion risks, how to integrate new hemorrhage control modalities, and how to deal with blood shortages. Less developed trauma systems are primarily concerned with speeding transport to specialized facilities and assembling trauma center resources. This article reviews the factors that effect blood use in urgent trauma care.

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  • Patients are often transfused unnecessarily or die from hemorrhage before receiving blood.

    “Because patients are often transfused unnecessarily or die from hemorrhage before receiving blood [33], we adjudicated the need for blood transfusion in these potential cases.”

    From To Recommend or Not to Recommend: Designing and Evaluating AI-Enabled Decision Support for Time-Critical Medical Events (2025) · cites this paper as [33]

    The Abstract says not everyone who receives blood benefits, and “Patterns of blood use” describes patients receiving blood despite no benefit. The Introduction identifies hemorrhage as a major cause of death, while “Can we use less blood?” says severely injured patients can die quickly without resuscitation. The paper does not establish that patients often die from hemorrhage specifically before receiving blood, or quantify how often unnecessary transfusion occurs. (LLM, conf=0.83)

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Cites

Flagged first, then by citations

Research works printed but not linked: 30

  1. Ozanne-Smith J Road traffic injury: a global health scourge: a review for World Health Day 2004 Aust NZ J Public Health 2004 28 109 112 15233347
  2. Sauaia A Moore FA Moore EE Moser KS Brennan R Read RA Pons PT Epidemiology of trauma deaths: a reassessment J Trauma 1995 38 185 193 7869433
  3. Trunkey DD History and development of trauma care in the United States Clin Orthop Relat Res 2000 347 36 46 10.1097/00003086-200005000-00005 10818967 · DOI
  4. Rotondo MF Zonies DH The damage control sequence and underlying logic Surg Clin North Am 1997 77 761 777 10.1016/S0039-6109(05)70582-X 9291979 · DOI
  5. Cosgriff N Moore EE Sauaia A Kenny-Moynihan M Burch JM Galloway B Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidosis revisited J Trauma 1997 42 857 861 discussion 861–862 9191667
  6. Como JJ Dutton RP Scalea TM Edelman BB Hess JR Blood transfusion rates in the care of acute trauma Transfusion 2004 44 809 813 10.1111/j.1537-2995.2004.03409.x 15157244 · DOI
  7. Moss GS Valeri CR Brodine CE Clinical experience with the use of frozen blood in combat casualties N Engl J Med 1968 278 747 752 4966301
  8. Thomas MJG Uncross-matched blood is unnecessary Hosp Med 2005 66 96 98 15739705
  9. Stainsby D MacLennan S Hamilton PJ Management of massive blood loss: a template guideline Br J Anaesth 2000 85 487 491 11103199
  10. Dutton RP Mackenzie CF Scalea TM Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality J Trauma 2002 52 1141 1146 12045644
  11. Hirshberg A Dugas M Banez EI Scott BG Wall MJ Jr Mattox KL Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation J Trauma 2003 54 454 463 12634523
  12. Spahn DR Strategies for transfusion therapy Best Pract Res Clin Anaesthesiol 2004 18 661 673 10.1016/j.bpa.2004.05.002 15460551 · DOI
  13. Johansson PI Hansen MB Sorensen H Transfusion practice in massively bleeding patients: time for a change? Vox Sang 2005 89 92 96 10.1111/j.1423-0410.2005.00668.x 16101690 · DOI
  14. Kermode JC Zheng Q Milner EP Marked temperature dependence of the platelet calcium signal induced by human von Willebrand factor Blood 1991 94 199 207 10381514
  15. Meng ZH Wolberg AS Monroe DM III Hoffman M The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients J Trauma 2003 55 886 891 14608161
  16. Levi M Ten Cate H Disseminated intravascular coagulation N Engl J Med 1999 314 586 592 10.1056/NEJM199908193410807 10451465 · DOI
  17. Armand R Hess JR Treating coagulopathy in trauma patients Transfus Med Rev 2003 17 223 231 10.1016/S0887-7963(03)00022-1 12881783 · DOI
  18. Lynn M Jeroukhimov I Klein Y Martinowitz U Updates in the management of severe coagulopathy in trauma patients Intensive Care Med 2002 28 Suppl 2 S241 S247 10.1007/s00134-002-1471-7 12404093 · DOI
  19. Hess JR Greenwalt TJ Storage of red blood cells: new approaches Transfus Med Rev 2002 16 283 295 10.1053/tmrv.2002.35212 12415514 · DOI
  20. Hiippala S Dextran and hydroxyethyl starch interfere with fibrinogen assays Blood Coagul Fibrinolysis 1995 6 743 746 8825225
  21. Napolitano LM Current status of blood component therapy in surgical critical care Curr Opin Crit Care 2004 10 311 317 10.1097/01.ccx.0000140948.98019.8a 15385744 · DOI
  22. Conry-Cantilena C Klein HG Training physicians in the discipline of transfusion medicine: 2004 Transfusion 2004 44 1252 1256 10.1111/j.1537-2995.2004.04094.x 15265132 · DOI
  23. Hiippala S Replacement of massive blood loss Vox Sang 1998 74 Suppl 2 399 407 9704474
  24. Cushing H From a Surgeon's Journal 1936 Boston, MA: Little, Brown & Co
  25. Moore EE Blood substitutes: the future is now J Am Coll Surg 2003 196 1 17 10.1016/S1072-7515(02)01704-0 12517544 · DOI
  26. Hess JR Update on alternative oxygen carriers Vox Sang 2004 Suppl 2 132 135 10.1111/j.1741-6892.2004.00469.x 15209897 · DOI
  27. Kenet G Walden R Eldad A Martinowitz U Treatment of traumatic bleeding with recombinant factor VIIa Lancet 1999 354 1879 10.1016/S0140-6736(99)05155-7 10584732 · DOI
  28. Dutton RP McCunn M Hyder M D'Angelo M O'Connor J Hess JR Scalea TM Factor VIIa for correction of traumatic coagulopathy J Trauma 2004 57 709 719 15514523
  29. Boffard KD Riou B Warren B Choong PI Rizoli S Rossaint R Axelsen M Kluger Y NovoSeven Trauma Study Group Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials J Trauma 2005 59 8 15 16096533
  30. Hess JR Thomas MJG Blood use in war and disaster: lessons from the last century Transfusion 2003 43 1622 1633 10.1046/j.1537-2995.2003.00576.x 14617324 · DOI

Cited by

Sorted by citations

Authors
Hess, J. R., & Hiippala, S. T.
Affiliations
  • University of Maryland, Baltimore (US)
  • University of Helsinki (FI)
Corresponding author
John R. Hess
Venue
Critical Care
Publisher
Springer Science and Business Media LLC
Published
2005
Volume
9
Issue
Suppl 5
Pages
S10
ISSN
1364-8535 (ISSN-L)
DOI
10.1186/cc3780
PMC
PMC3226118
OpenAlex
W1583326716
Cited by
63
References
1
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 1 · 2014: 3 · 2012: 9
Type
conference abstract
Language
en
Open access
Locations
  • Critical Care (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Social Sciences › Business, Management and Accounting › Management of Technology and Innovation › Blood donation and transfusion practices
Keywords
blood transfusion, trauma care, massive transfusion, transfusion risks, hemorrhage control, blood shortage, trauma systems, trauma transport
MeSH terms
Adult, Blood Banks, Blood Transfusion, Critical Care, Humans, Resuscitation, Trauma Centers, Wounds and Injuries, Platelet Transfusion

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