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Cited by 347

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review

Open access
Cruz, Dinna N, Perazella, Mark A, Bellomo, Rinaldo, de Cal, Massimo, Polanco, Natalia, Corradi, Valentina, Lentini, Paolo, Nalesso, Federico, Ueno, Takuya, Ranieri, V Marco, Ronco, Claudio·2007·Critical Care
DOI 10.1186/cc5780
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Abstract

Introduction: Severe sepsis and septic shock are common problems in the intensive care unit and carry a high mortality. Endotoxin, one of the principal components on the outer membrane of gram-negative bacteria, is considered important to their pathogenesis. Polymyxin B bound and immobilized to polystyrene fibers (PMX-F) is a medical device that aims to remove circulating endotoxin by adsorption, theoretically preventing the progression of the biological cascade of sepsis. We performed a systematic review to describe the effect in septic patients of direct hemoperfusion with PMX-F on outcomes of blood pressure, use of vasoactive drugs, oxygenation, and mortality reported in published studies. Methods: We searched PubMed, the Cochrane Collaboration Database, and bibliographies of retrieved articles and consulted with experts to identify relevant studies. Prospective and retrospective observational studies, pre- and post-intervention design, and randomized controlled trials were included. Three authors reviewed all citations. We identified a total of 28 publications – 9 randomized controlled trials, 7 non-randomized parallel studies, and 12 pre-post design studies – that reported at least one of the specified outcome measures (pooled sample size, 1,425 patients: 978 PMX-F and 447 conventional medical therapy). Results: Overall, mean arterial pressure (MAP) increased by 19 mm Hg (95% confidence interval [CI], 15 to 22 mm Hg; p < 0.001), representing a 26% mean increase in MAP (range, 14% to 42%), whereas dopamine/dobutamine dose decreased by 1.8 μg/kg per minute (95% CI, 0.4 to 3.3 μg/kg per minute; p = 0.01) after PMX-F. There was significant intertrial heterogeneity for these outcomes (p < 0.001), which became non-significant when analysis was stratified for baseline MAP. The mean arterial partial pressure of oxygen/fraction of inspired oxygen (PaO 2/FiO 2) ratio increased by 32 units (95% CI, 23 to 41 units; p < 0.001). PMX-F therapy was associated with significantly lower mortality risk (risk ratio, 0.53; 95% CI, 0.43 to 0.65). The trials assessed had suboptimal method quality. Conclusion: Based on this critical review of the published literature, direct hemoperfusion with PMX-F appears to have favorable effects on MAP, dopamine use, PaO 2/FiO 2 ratio, and mortality. However, publication bias and lack of blinding need to be considered. These findings support the need for further rigorous study of this therapy.

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Metadata

Authors
Cruz, D. N., Perazella, M. A., Bellomo, R., de Cal, M., Polanco, N., Corradi, V., Lentini, P., Nalesso, F., Ueno, T., Ranieri, V. M., & Ronco, C.
Venue
Critical Care
Publisher
Springer Science and Business Media LLC
Published
2007-04-20
Volume
11
Issue
2
Pages
R47-R47
ISSN
1364-8535 (ISSN-L)
DOI
10.1186/cc5780
OpenAlex
W2123255995
Cited by
347
References
37
FWCI
3.23
Type
journal article
Language
en
Open access
gold

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