The role of inflammation in ICU-acquired weakness
Open accessAbstract
A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW. While this finding is somewhat equivocal, it provides important direction for future investigations and illustrates the challenges of interpreting significance in small observational studies.
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Inflammation and sepsis are major risk factors for ICUAW.
“Inflammation and sepsis are major risk factors for ICUAW.”
From Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting (2022) · cites this paper as [9]
The Abstract says systemic inflammatory pathology is suggested to be the most significant risk factor for ICU-acquired weakness, but calls that finding equivocal. It also notes differences in septic shock between patient groups; it does not establish sepsis itself as a major risk factor. (LLM, conf=0.86)
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Weber-Carstens, S., Deja, M., Koch, S., Spranger, J., Bubser, F., Wernecke, K. D., Spies, C. D., Spuler, S., & Keh, D. (2010) · Critical Care · doi:10.1186/cc9074 · Cited by 132 · see citing works
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Research works printed but not linked: 14
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Cited by
Sorted by citations
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12867 · Cited by 225 · see citing works
“Clinical data were reported previously.11 We analysed mRNA expression in biopsy specimens obtained from the vastus lateralis muscle of patients at high risk to develop ICUAW.”
BackgroundInfluentialDeletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
Huang, N., Kny, M., Riediger, F., Busch, K., Schmidt, S., Luft, F. C., Slevogt, H., & Fielitz, J. (2017) · Intensive Care Medicine Experimental · doi:10.1186/s40635-016-0115-0 · Cited by 95 · see citing works
- Authors
- Winkelman, C.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Winkelman, Chris
- ORCID
- Winkelman, Chris
- Venue
- Critical Care
- Published
- 2010
- Volume
- 14
- Issue
- 4
- Pages
- 186
- ISSN
- 1364-8535 (ISSN-L)
- PMC
- PMC2945106
- OpenAlex
- W2133014873
- Cited by
- 23
- References
- 1
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 4 · 2013: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Critical Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- ICU-acquired weakness, inflammation, systemic inflammation, risk factors, critical illness, small sample size
- MeSH terms
- Humans, Intensive Care Units, Interleukin-6, Systemic Inflammatory Response Syndrome, Muscle Weakness
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