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The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes

Open access
Todd J. Treangen, Brian Ondov, Sergey Koren, Adam M. Phillippy·2014·Genome biology

Abstract

Whole-genome sequences are now available for many microbial species and clades, however existing whole-genome alignment methods are limited in their ability to perform sequence comparisons of multiple sequences simultaneously. Here we present the Harvest suite of core-genome alignment and visualization tools for the rapid and simultaneous analysis of thousands of intraspecific microbial strains. Harvest includes Parsnp, a fast core-genome multi-aligner, and Gingr, a dynamic visual platform. Together they provide interactive core-genome alignments, variant calls, recombination detection, and phylogenetic trees. Using simulated and real data we demonstrate that our approach exhibits unrivaled speed while maintaining the accuracy of existing methods. The Harvest suite is open-source and freely available from: http://github.com/marbl/harvest.

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OpenAlex · 10.1186/preaccept-2573980311437212

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Metadata

Authors
Treangen, T. J., Ondov, B., Koren, S., & Phillippy, A. M.
Venue
Genome biology
Publisher
BioMed Central
Published
2014-01-01
Volume
15
Issue
11
Pages
524-524
ISSN
1465-6906 (ISSN-L)
OpenAlex
W2118442768
Cited by
1,654
References
18
FWCI
22.39
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes. https://app.cochat.ai/papers/10.1186/preaccept-2573980311437212
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Treangen, T. J., Ondov, B., Koren, S., & Phillippy, A. M. (2014). The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomes. Genome biology. https://doi.org/10.1186/preaccept-2573980311437212

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