Progressive muscle relaxation reduces migraine frequency and normalizes amplitudes of contingent negative variation (CNV)
Open accessAbstract
BACKGROUND: Central information processing, visible in evoked potentials like the contingent negative variation (CNV) is altered in migraine patients who exhibit higher CNV amplitudes and a reduced habituation. Both characteristics were shown to be normalized under different prophylactic migraine treatment options whereas Progressive Muscle Relaxation (PMR) has not yet been examined. We investigated the effect of PMR on clinical course and CNV in migraineurs in a quasi-randomized, controlled trial. METHODS: Thirty-five migraine patients and 46 healthy controls were examined. Sixteen migraineurs and 21 healthy participants conducted a 6-week PMR-training with CNV-measures before and after as well as three months after PMR-training completion. The remaining participants served as controls. The clinical course was analyzed with two-way analyses of variance (ANOVA) with repeated measures. Pre-treatment CNV differences between migraine patients and healthy controls were examined with t-tests for independent measures. The course of the CNV-parameters was examined with three-way ANOVAs with repeated measures. RESULTS: After PMR-training, migraine patients showed a significant reduction of migraine frequency. Preliminary to the PMR-training, migraine patients exhibited higher amplitudes in the early component of the CNV (iCNV) and the overall CNV (oCNV) than healthy controls, but no differences regarding habituation. After completion of the PMR-training, migraineurs showed a normalization of the iCNV amplitude, but neither of the oCNV nor of the habituation coefficient. CONCLUSIONS: The results confirm clinical efficacy of PMR for migraine prophylaxis. The pre-treatment measure confirms altered cortical information processing in migraine patients. Regarding the changes in the iCNV after PMR-training, central nervous mechanisms of the PMR-effect are supposed which may be mediated by the serotonin metabolism.
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RLX represents one of the most evidence-based treatments for migraine prophylaxis, having even an impact on physiological parameters.
“Since RLX represents one of the most evidence-based treatments for migraine prophylaxis, having even an impact on physiological parameters, (17)”
From Efficacy of Cognitive-Behavioral Therapy for the Prophylaxis of Migraine in Adults: A Three-Armed Randomized Controlled Trial (2022) · cites this paper as [17]
The Background (page unavailable) says progressive muscle relaxation received a Grade A recommendation for migraine prevention, but cautions that methodological shortcomings make its empirical basis less solid than expected. The Discussion section on longitudinal CNV data (page unavailable) reports normalization of a physiological measure after training. The claim is supported on prophylactic and physiological effects, but its unqualified description as one of the most evidence-based treatments overlooks the paper’s caveat. (LLM, conf=0.84)
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References 41 · Cited by 81
Research works printed but not linked: 1
- [22]Goslin RE Gray RN McCrory DC Penzien D Rains J Hasselblad V Behavioral and physical treatments for migraine headache 1999 20734517
- Authors
- Meyer, B., Keller, A., Wöhlbier, H.-G., Overath, C. H., Müller, B., & Kropp, P.
- Affiliations
- Universitätsmedizin Rostock (DE)
- University Hospital Schleswig-Holstein (DE)
- Corresponding author
- Meyer, Bianca
- Venue
- The Journal of Headache and Pain
- Published
- 2016-04-18
- Volume
- 17
- Issue
- 1
- Pages
- 37-37
- ISSN
- 1129-2369 (ISSN-L)
- 1129-2377
- PMC
- PMC4835398
- OpenAlex
- W2339146840
- Cited by
- 81
- References
- 41
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 22 · 2022: 14 · 2021: 4 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 3 · 2016: 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Journal of Headache and Pain (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Deutsche Migräne- und Kopfschmerzgesellschaft
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- progressive muscle relaxation, migraine, migraine prophylaxis, contingent negative variation, migraine frequency, cortical processing, serotonin metabolism, relaxation training
- MeSH terms
- Adult, Autogenic Training, Brain, Contingent Negative Variation, Female, Humans, Male, Migraine Disorders, Treatment Outcome
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