Interaction between intensity and duration of acute exercise on neuronal activity associated with depression-related behavior in rats
Open accessAbstract
We examined the activities of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) and corticotropin-releasing factor (CRF) neurons in the hypothalamic paraventricular nucleus (PVN) during acute treadmill running at different speeds (control, low, high) and durations (15, 30, 60 min) in male Wistar rats using c-Fos/5-HT or CRF immunohistochemistry. We also performed elevated plus maze test (EPM) and forced swim test (FST) after acute treadmill running in rats. Acute treadmill running at low speed, regardless of exercise duration, significantly increased c-Fos expression in 5-HT neurons in the DRN compared with controls, whereas high-speed running significantly activated 5-HT neurons only at 60-min duration. In contrast, c-Fos expression in CRF neurons in the PVN was enhanced in an intensity-dependent manner, regardless of exercise duration. c-Fos expression in 5-HT neurons in the DRN induced by the acute treadmill running for 30 or 60 min, but not 15 min, was positively correlated with the time spent on the open arms in the EPM and was negatively correlated with the immobility time in the FST. These results suggest an interaction between exercise intensity and duration on the antidepressant effects of acute physical exercise.
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Exercise intensity is positively associated with BDNF and plasma endorphin release.
“Exercise intensity is positively associated with BDNF and plasma endorphin release [111].”
From Systematic review and meta-analysis of the effects of exercise on depression in adolescents (2022) · cites this paper as [111]
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References 60 · Cited by 22
Research works printed but not linked: 1
- [34]Perez-Caballero L Torres-Sanchez S Romero-Lopez-Alberca C Gonzalez-Saiz F Mico JA Berrocoso E Monoaminergic system and depression Cell Tissue Res 2019 377 107 113 10.1007/s00441-018-2978-8 30627806 · DOI
- Authors
- Morikawa, R., Kubota, N., Amemiya, S., Nishijima, T., & Kita, I.
- Affiliations
- Tokyo Metropolitan University (JP)
- Corresponding author
- Kita, Ichiro
- Venue
- The Journal of Physiological Sciences
- Publisher
- Elsevier BV
- Published
- 2021
- Volume
- 71
- Issue
- 1
- Pages
- 1
- ISSN
- 1880-6546 (ISSN-L)
- PMC
- PMC10717066
- OpenAlex
- W3124875139
- Cited by
- 22
- References
- 60
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 1 · 2022: 1 · 2021: 1
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The Journal of Physiological Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (JSPS KAKENHI Grant No. 16K13017, JSPS KAKENHI Grant No. 18K10852)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- exercise intensity, exercise duration, serotonergic neurons, dorsal raphe nucleus, corticotropin-releasing hormone neurons, paraventricular nucleus, Fos expression, antidepressant effects of exercise, elevated plus maze, forced swim test, immobility time
- MeSH terms
- Elevated Plus Maze Test, Animals, Brain, Depression, Male, Neurons, Physical Conditioning, Animal, Serotonin, Time Factors, Rats, Wistar, Rats
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