Cardiac tissue oxidative stress and inflammation after vitamin D administrations in high fat- diet induced obese rats
Open accessAbstract
BACKGROUND: Obesity is associated with numerous metabolic and inflammatory disorders. The current study was aimed to evaluate the effects of vitamin D administration on the markers of oxidative stress and inflammation in the cardiac tissue of high-fat diet induced obese rats. METHODS: In the beginning of the study, 40 male Wistar rats were divided into two groups: normal diet (ND) and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: ND, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage. Tumor necrosis factor (TNF)-α concentration and markers of oxidative stress including glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA) and catalase (CAT) concentrations in the cardiac tissue and serum concentrations of lipids in rats were determined using ELISA kits and spectrophotometry methods respectively. RESULTS: According to our results, GPx activity in ND and ND + vitamin D group was significantly higher compared with HFD group. Similarly, SOD activity was also significantly increased in ND + vitamin D group compared with ND and HFD groups. Moreover, vitamin D administration, significantly reduced catalase activity in ND + vitamin D and HFD + vitamin D groups (P < 0.05). TNF-α concentration in heart tissue in ND + vitamin D group significantly reduced compared with ND group. Cardiac tissue MDA concentration in baseline or after vitamin D administration did not changed significantly. CONCLUSION: Vitamin D improved cardiac oxidative stress and inflammatory markers in HFD induced obese rats. Further studies in human models are needed to further confirm the use of this nutrient in daily clinical practice.
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Vitamin D alone but more convincingly in combination with vitamin E decreased oxidative stress in cardiomyocytes, reduced inflammatory markers, and suppressed apoptosis, hypertrophy, and other ailments in obese rats.
“Vitamin D alone but more convincingly in combination with vitamin E decreased oxidative stress in cardiomyocytes, reduced inflammatory markers, and suppressed apoptosis, hypertrophy, and other ailments in obese rats (Farhangi et al. 2017).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Farhangi et al. 2017
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References 50 · Cited by 81
Research works printed but not linked: 2
- [17]Tardif JC, Bourassa MG. Use of antioxidants in patients with heart failure. Antioxidants and cardiovascular disease. USA: Springer Science & Business Media; 2012. p. 213.
- [50]McGill AT Stewart JM Lithander FE Strik CM Poppitt SD Relationships of low serum vitamin D 3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity Nutr J 2008 7 1 4 10.1186/1475-2891-7-4 18226257 PMC2265738 · DOI
- Authors
- Farhangi, M. A., Nameni, G., Hajiluian, G., & Mesgari-Abbasi, M.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Corresponding author
- Farhangi, Mahdieh Abbasalizad
- Venue
- BMC Cardiovascular Disorders
- Published
- 2017-06-19
- Volume
- 17
- Issue
- 1
- Pages
- 161-161
- ISSN
- 1471-2261 (ISSN-L)
- PMC
- PMC5477304
- OpenAlex
- W2672830024
- Cited by
- 81
- References
- 50
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 7 · 2022: 13 · 2021: 8 · 2020: 14 · 2019: 10 · 2018: 10
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Cardiovascular Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tabriz University of Medical Sciences
- University of Tabriz
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- vitamin D supplementation, obesity, high-fat diet, cardiac oxidative stress, inflammation, TNF-α, superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, lipid peroxidation, cardioprotection
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Catalase, Disease Models, Animal, Glutathione Peroxidase, Inflammation, Lipids, Male, Malondialdehyde, Myocardium, Obesity, Superoxide Dismutase, Time Factors, Tumor Necrosis Factor-alpha, Vitamin D, Biomarkers, Rats, Wistar, Oxidative Stress, Inflammation Mediators
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