Immediate postoperative parenteral anticoagulant therapy in patients with mesenteric ischemia after intestinal resection: a retrospective cohort study at a single institute
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Abstract
Background: Bowel gangrene represents a major fatal event in acute mesenteric ischemia. Intestinal resection is inevitable in patients with peritonitis and bowel gangrene. This retrospective study aimed to elucidate the benefit of postoperative parenteral anticoagulation in patients with intestinal resection. Methods: Patients with acute mesenteric ischemia and bowel gangrene were recruited retrospectively between January 2007 and December 2019. All patients underwent bowel resection. They were categorized into two groups: patients without immediate parenteral anticoagulant therapy (Group A) and those with immediate parenteral anticoagulant therapy (Group B). Thirty-day mortality and survival were analyzed. Results: A total of 85 patients were included, with 29 patients in Group A and 56 patients in Group B. Patients in Group B had lower 30-day mortality (16.1%) and a higher 2-year survival rate (45.4%) than patients in Group A (30-day mortality: 51.7%, p = 0.001; 2-year survival rate: 19.0%, p = 0.001). In the 30-day mortality multivariate analysis, patients in Group B had a better outcome (odds ratio = 0.080, 95% confidence interval between 0.011 and 0.605, p = 0.014). Patients in Group B also had a better outcome in the survival multivariate analysis (hazard ratio: 0.435, 95% confidence interval between 0.213 and 0.887, p = 0.022). Conclusions: Immediate postoperative parenteral anticoagulant therapy improves prognosis in patients with acute mesenteric ischemia treated by intestinal resection. Trial registration This research was retrospectively approved by the Institutional Review Board (IRB) I&II of Taichung Veterans General Hospital (TCVGH-IRB No.CE21256B) on July 28th, 2021. The informed consent waiver was also approved by IRB I&II of Taichung Veterans General Hospital. The Declaration of Helsinki and ICH-GCP guidelines were followed during this study.
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Immediate postoperative parenteral anticoagulant therapy improves prognosis in patients undergoing intestinal resection.
“A recent study found that immediate postoperative parenteral anticoagulant therapy improves prognosis in patients undergoing intestinal resection [36].”
From Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review (2024) · cites this paper as [36]
The Conclusions report increased survival with immediate postoperative parenteral anticoagulation after resection, but specifically in patients with acute mesenteric ischemia and intestinal gangrene. The citing sentence omits that restriction and presents the finding as applying to patients undergoing intestinal resection generally. (LLM, conf=0.88)
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References 43 · Cited by 6
- Authors
- Liu, H.-T., Lai, C.-Y., Liao, J.-J., Chen, Y.-J., Cheng, S.-B., & Wu, C.-C.
- Affiliations
- Taichung Veterans General Hospital (TW)
- Chung Shan Medical University (TW)
- Corresponding author
- Liu, Hsiao-Tien
- Venue
- BMC Gastroenterology
- Published
- 2023-03-08
- Volume
- 23
- Issue
- 1
- Pages
- 56-56
- ISSN
- 1471-230X (ISSN-L)
- PMC
- PMC9996985
- OpenAlex
- W4323544498
- Cited by
- 6
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Gastroenterology (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Taichung Veterans General Hospital (TCVGH-1114601A)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- acute mesenteric ischemia, intestinal necrosis, bowel resection, parenteral anticoagulation, 30-day mortality, long-term survival, peritonitis
- MeSH terms
- Anticoagulants, Gangrene, Humans, Ischemia, Prognosis, Retrospective Studies, Treatment Outcome, Mesenteric Ischemia
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