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Cited by 53Salmonella and Campylobacter epidemiologyBacterial Infections and VaccinesBacterial Identification and Susceptibility Testing

Salmonella blood stream infections in a tertiary care setting in Ghana

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Labi, Appiah-Korang, Obeng-Nkrumah, Noah, Addison, Naa Okaikor, Donkor, Eric Sampene·2014·BMC Infectious Diseases
DOI 10.1186/s12879-014-0697-7PMC PMC4297363
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Abstract

BACKGROUND: Despite the clinical significance of Salmonella infections, surveillance data worldwide remains limited and is more so exemplified by the lack of reports from Africa especially in eastern, central and western Africa. This study reports on Salmonella serotypes as significant causes of blood stream infections (BSI) and multidrug antibiotic resistance at Korle-Bu Teaching Hospital in Accra, Ghana. METHODS: Antibiogram patterns, seasonal variations in disease incidence and predisposing factors for infection with Salmonella serotypes were analyzed retrospectively over a 4-year period from January 2010 to December 2013. Blood cultures were processed with BACTEC 9240 blood culture system. Speciation was done with BBL Crystal Enteric/Nonfermenter identification system®, and with slide agglutination using specific antisera. Antimicrobial susceptibility testing was carried out by the Kirby-Bauer disc diffusion method according to Clinical and Laboratory Standard Institute guidelines. RESULTS: We report a 6.5% (n = 181/2768) prevalence of Salmonella bacteraemia at the Korle-Bu Teaching Hospital; with a preponderance of non-typhoidal salmonellae (NTS) over typhoidal salmonella (TS) (n = 115/181, 63.5% versus n = 66/181, 36.5%; P-value <0.002). Children under 5 years bore the brunt of the disease (n = 93/174, 53.4%). Resistance to ciprofloxacin (n = 1/127, 0.7%), amikacin (n = 3/81, 3.7%), and cefotaxime (n = 6/99, 6.1%) remained low, despite high levels of multidrug resistant Salmonella phenotypes (n = 81/181, 44.2%). In multivariate analysis, and among patients with Salmonella BSI, those < 1 year old had reduced risk of non-typhoidal infections [Odds ratio, 0.51; 95% confidence interval (95% CI), 0.16-0.92, P-value 0.021]. Similarly, patients with cefuroxime resistant strans were at increased risk of having multidrug resistant Salmonella BSI (OR, 8.97; 95% CI, 3.62-24.15; P-value, 0.001). CONCLUSIONS: Salmonellae, predominantly NTS, account for a reasonable low proportion of positive blood cultures in our tertiary care setting; but with significant multidrug resistant phenotypes and low ciprofloxacin and cefotaxime resistance.

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  • In human studies, two reported MDR in Salmonella spp. at a prevalence of 41.5% and 99.6%.

    “Two others reported MDR in Salmonella spp. at a prevalence of 41.5% and 99.6% [39,62].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [39]

    The Results section, “Multidrug resistance salmonellae” (page unavailable), reports MDR in 81 of 181 Salmonella isolates (44.8%), not 41.5% or 99.6%. The cited paper therefore does not support either prevalence attributed to the two cited studies. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Labi, A.-K., Obeng-Nkrumah, N., Addison, N. O., & Donkor, E. S.
Affiliations
  • Korle Bu Teaching Hospital (GH)
  • University of Ghana (GH)
ORCID
Venue
BMC Infectious Diseases
Publisher
Springer Science and Business Media LLC
Published
2014-12
Volume
14
Issue
1
Pages
3857-3857
ISSN
1471-2334 (ISSN-L)
DOI
10.1186/s12879-014-0697-7
PMC
PMC4297363
OpenAlex
W2115880131
Cited by
53
References
1
Citations by year
2026: 6 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 7 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5
FWCI
6.21
Type
journal article
Language
en
Update notices
erratum (2015-07-10)
Open access
Licence
Locations
  • BMC Infectious Diseases (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Greater South Information System
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords
bloodstream infection, non-typhoidal Salmonella, typhoidal Salmonella, multidrug resistance, antimicrobial resistance, cefuroxime resistance, ciprofloxacin resistance, amikacin resistance, cefotaxime resistance, serotyping, seasonal variation, children under five, risk factors, Ghana, Accra, Korle Bu Teaching Hospital
MeSH terms
Adolescent, Adult, Aged, Anti-Bacterial Agents, Cefuroxime, Child, Child, Preschool, Female, Ghana, Humans, Infant, Infant, Newborn, Male, Middle Aged, Retrospective Studies, Salmonella, Salmonella enteritidis, Salmonella Infections, Salmonella paratyphi A, Salmonella typhi, Salmonella typhimurium, Seasons, Bacteremia, Drug Resistance, Multiple, Bacterial, Disk Diffusion Antimicrobial Tests, Young Adult, Tertiary Care Centers

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