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Cited by 182Parasitic infections in humans and animalsParasitic Infections and DiagnosticsParasites and Host Interactions

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Medical treatment of cystic echinococcosis: systematic review and meta-analysis

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Velasco-Tirado, Virginia, Alonso-Sardón, Montserrat, Lopez-Bernus, Amparo, Romero-Alegría, Ángela, Burguillo, Francisco Javier, Muro, Antonio, Carpio-Pérez, Adela, Muñoz Bellido, Juan Luis, Pardo-Lledias, Javier, Cordero, Miguel, Belhassen-García, Moncef·2018·BMC Infectious Diseases
DOI 10.1186/s12879-018-3201-yPMC PMC6034244
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Abstract

BACKGROUND: Cystic echinococcosis (CE) is a well-known neglected parasitic disease. However, evidence supporting the four current treatment modalities is inadequate, and treatment options remain controversial. The aim of this work is to analyse the available data to answer clinical questions regarding medical treatment of CE. METHODS: A thorough electronic search of the relevant literature without language restrictions was carried out using PubMed (Medline), Cochrane Central Register of Controlled Trials, BioMed, Database of Abstracts of Reviews of Effects, and Cochrane Plus databases up to February 1, 2017. All descriptive studies reporting an assessment of CE treatment and published in a peer-reviewed journal with available full-text were considered for a qualitative analysis. Randomized controlled trials were included in a quantitative meta-analysis. We used the standard methodological procedures established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. RESULTS: We included 33 studies related to the pharmacological treatment of CE in humans. Of these, 22 studies with levels of evidence 2 to 4 were qualitatively analysed, and 11 randomized controlled trials were quantitatively analysed by meta-analysis. CONCLUSIONS: Treatment outcomes are better when surgery or PAIR (Puncture, Aspiration, Injection of protoscolicidal agent and Reaspiration) is combined with benzimidazole drugs given pre- and/or post-operation. Albendazole chemotherapy was found to be the primary pharmacological treatment to consider in the medical management of CE. Nevertheless, combined treatment with albendazole plus praziquantel resulted in higher scolicidal and anti-cyst activity and was more likely to result in cure or improvement relative to albendazole alone.

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Metadata

Authors
Velasco-Tirado, V., Alonso-Sardón, M., Lopez-Bernus, A., Romero-Alegría, Á., Burguillo, F. J., Muro, A., Carpio-Pérez, A., Muñoz Bellido, J. L., Pardo-Lledias, J., Cordero, M., & Belhassen-García, M.
Affiliations
Universidad de Salamanca (ES)
ORCID
Venue
BMC Infectious Diseases
Publisher
Springer Science and Business Media LLC
Published
2018-07-05
Volume
18
Issue
1
Pages
306-306
ISSN
1471-2334 (ISSN-L)
DOI
10.1186/s12879-018-3201-y
PMC
PMC6034244
OpenAlex
W2849922468
Cited by
182
References
0
Citations by year
2026: 21 · 2025: 30 · 2024: 23 · 2023: 28 · 2022: 17 · 2021: 38 · 2020: 18 · 2019: 6
FWCI
2.29
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Infectious Diseases (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Gredos (University of Salamanca) (acceptedVersion, cc-by-nc-nd)
  • Hispana (acceptedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCrea (University of Cantabria) (submittedVersion, cc-by)
Funders
  • Health Research Projects: Technological Development Project in Health (DTS16/00207)
  • Health Research Project (PI16/ 01784)
  • Proyectos Integrados IBSAL (IBY15/00003)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
echinococcosis, medical treatment, albendazole, praziquantel, scolicidal activity, combination chemotherapy, parasitic liver disease
MeSH terms
Anthelmintics, Benzimidazoles, Drug Therapy, Combination, Echinococcosis, Humans, Praziquantel, Albendazole, Databases, Factual, Treatment Outcome, Neglected Diseases

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