CoChat
Sign Up
Cited by 98Dialysis and Renal Disease ManagementPhysical Activity and HealthCardiovascular and exercise physiology

Effects of home-based exercise on pre-dialysis chronic kidney disease patients: a randomized pilot and feasibility trial

Open access
Hiraki, Koji, Shibagaki, Yugo, Izawa, Kazuhiro P., Hotta, Chiharu, Wakamiya, Akiko, Sakurada, Tsutomu, Yasuda, Takashi, Kimura, Kenjiro·2017·BMC Nephrology
DOI 10.1186/s12882-017-0613-7PMC PMC5474300
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Only a few research is available on the effects of home-based exercise training on pre-dialysis chronic kidney disease (CKD) patients. Therefore, we aimed to elucidate the effect of home-based exercise therapy on kidney function and arm and leg muscle strength in pre-dialysis CKD patients. METHODS: ) who were being treated as outpatients were included. The subjects were randomly assigned to an exercise intervention group (Ex group: 18) and a control group (C group: 18). The Ex group wore accelerometer pedometers and were instructed to perform home-based aerobic and resistance exercises, such as brisk walking for 30 min per day, for 12 months. The C group subjects wore accelerometer pedometers but received no exercise therapy guidance; the number of steps covered during normal daily activities was recorded for the C group. The outcome measures were changes in kidney function and handgrip and knee extension muscle strength. Values at the baseline (T1) and 12 months later (T2) were compared. RESULTS: There were no significant differences in baseline characteristics between the two groups; however, the C group was more physically active than the Ex group. Eight subjects dropped out, and 28 subjects (14 in each group) were included in the final analysis. Physical activity increased significantly only in the Ex group. Grip strength (F = 7.0, p = 0.01) and knee extension muscle strength (F = 14.3, p < 0.01) were found to improve only in the Ex group. Further, the changes in eGFR were not significantly different between the two groups (F = 0.01, p = 0.93). CONCLUSIONS: Home-based exercise therapy for pre-dialysis CKD patients was feasible and improved arm and leg muscle strength without affecting kidney function. TRIAL REGISTRATION: UMIN Clinical Trials Registry ( UMIN000005091 ). Registered 2/15/2011.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s12882-017-0613-7

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 23

  1. [1]Heiwe S Tollbäck A Clyne N Twelve weeks of exercise training increases muscle function and walking capacity in elderly predialysis patients and healthy subjects Nephron 2001 88 48 56 10.1159/000045959 11340351 · DOI
  2. [2]Padilla J, Krasnoff J, Da Silva M, Hsu CY, Frassetto L, Johansen KL, et al. Physical functioning in patients with chronic kidney disease. J Nephrol. 2008;21:550–9. 18651545
  3. [3]Odden MC Chertow GM Fried LF Newman AB Connelly S Angleman S HABC study: Cystatin C and measures of physical function in elderly adults: the health, aging, and body composition (HABC) study Am J Epidemiol 2006 164 1180 1189 10.1093/aje/kwj333 17035344 · DOI
  4. [4]Hiraki K Yasuda T Hotta C Izawa KP Morio Y Watanabe S Decreased physical function in pre-dialysis patients with chronic kidney disease Clin Exp Nephrol 2013 17 225 231 10.1007/s10157-012-0681-8 22911116 · DOI
  5. [5]Reese PP Cappola AR Shults J Townsend RR Gadegbeku CA Anderson C CRIC study investigators: physical performance and frailty in chronic kidney disease Am J Nephrol 2013 38 307 315 10.1159/000355568 24107579 PMC4019506 · DOI
  6. [6]Chang YT Wu HL Guo HR Cheng YY Tseng CC Wang MC Handgrip strength is an independent predictor of renal outcomes in patients with chronic kidney diseases Nephrol Dial Transplant 2011 26 3588 3595 10.1093/ndt/gfr013 21444362 · DOI
  7. [7]Roshanravan B Robinson-Cohen C Patel KV Ayers E Littman AJ de Boer IH Association between physical performance and all-cause mortality in CKD J Am Soc Nephrol 2013 24 822 830 10.1681/ASN.2012070702 23599380 PMC3636794 · DOI
  8. [8]Watson EL Greening NJ Viana JL Aulakh J Bodicoat DH Barratt J Progressive resistance exercise training in CKD: a feasibility study Am J Kidney Dis 2015 66 249 257 10.1053/j.ajkd.2014.10.019 25533601 · DOI
  9. [9]Heiwe S Jacobson SH Exercise training in adults with CKD: a systematic review and meta-analysis Am J Kidney Dis 2014 64 383 393 10.1053/j.ajkd.2014.03.020 24913219 · DOI
  10. [10]Heiwe S, Jacobson SH. Exercise training for adults with chronic kidney disease. Cochrane Database Syst Rev10: 2011. PMC10183198 21975737
  11. [11]Johansen KL Painter P Exercise in individuals with CKD Am J Kidney Dis 2012 9 126 134 10.1053/j.ajkd.2011.10.008 PMC3242908 22113127 · DOI
  12. [12]Izawa KP Oka K Watanabe S Yokoyama H Hiraki K Morio Y Gender-related differences in clinical characteristics and physiological and psychosocial outcomes of Japanese patients at entry into phase II cardiac rehabilitation J Rehabil Med 2008 40 225 230 10.2340/16501977-0156 18292926 · DOI
  13. [14]Izawa KP Watanabe S Hiraki K Morio Y Kasahara Y Takeichi N Determination of the effectiveness of accelerometer use in the promotion of physical activity in cardiac patients: a randomized controlled trial Arch Phys Med Rehabil 2012 93 1896 1902 10.1016/j.apmr.2012.06.015 22750166 · DOI
  14. [15]Kumahara H Schutz Y Ayabe M Yoshioka M Yoshitake Y Shindo M The use of uniaxial accelerometry for the assessment of physical-activity-related energy expenditure: a validation study against whole-body indirect calorimetry Br J Nutr 2004 91 235 243 10.1079/BJN20031033 14756909 · DOI
  15. [16]Izawa KP Watanabe S Oka K Kobayashi T Osada N Omiya K The effects of unsupervised exercise training on physical activity and physiological factors after supervised cardiac rehabilitation J Jpn Phys Ther Assoc 2006 9 1 8 10.1298/jjpta.9.1 25792944 PMC4316499 · DOI
  16. [17]Borg G Perceived exertion as an indicator of somatic stress Scand J Rehabil Med 1970 2 92 98 5523831
  17. [18]Matsuo S Imai E Horio M Yasuda Y Tomita K Nitta K Collaborators developing the Japanese equation for estimated GFR Revised equations for estimated GFR from serum creatinine in Japan Am J Kidney Dis 2009 53 982 992 10.1053/j.ajkd.2008.12.034 19339088 · DOI
  18. [19]Thiebaud RS Funk MD Abe T Home-based resistance training for older adults: a systematic review Geriatr Gerontol Int 2014 14 750 757 10.1111/ggi.12326 25109883 · DOI · Paper page
  19. [20]Bravata DM Smith-Spangler C Sundaram V Gienger AL Lin N Lewis R Using pedometers to increase physical activity and improve health: a systematic review JAMA 2007 298 2296 2304 10.1001/jama.298.19.2296 18029834 · DOI · Paper page
  20. [21]Castaneda C Gordon PL Uhlin KL Levey AS Kehayias JJ Dwyer JT Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency. A randomized, controlled trial Ann Intern Med 2001 135 965 976 10.7326/0003-4819-135-11-200112040-00008 11730397 · DOI · Paper page
  21. [22]Lorenzo V Saracho R Zamora J Rufino M Torres A Similar renal decline in diabetic and non-diabetic patients with comparable levels of albuminuria Nephrol Dial Transplant 2010 25 835 841 10.1093/ndt/gfp475 19762600 · DOI
  22. [23]Eidemak I Haaber AB Feldt-Rasmussen B Kanstrup IL Strandgaard S Exercise training and the progression of chronic renal failure Nephron 1997 75 36 40 10.1159/000189497 9031268 · DOI
  23. [25]Robinson-Cohen C Littman AJ Duncan GE Weiss NS Sachs MC Ruzinski J Physical activity and change in estimated GFR among persons with CKD J Am Soc Nephrol 2014 25 399 406 10.1681/ASN.2013040392 24335971 PMC3904564 · DOI

Cited by

Sorted by citations

Authors
Hiraki, K., Shibagaki, Y., Izawa, K. P., Hotta, C., Wakamiya, A., Sakurada, T., Yasuda, T., & Kimura, K.
Affiliations
  • St. Marianna University School of Medicine (JP)
  • Kobe University (JP)
  • Japan Community Healthcare Organization (JP)
Corresponding author
Shibagaki, Yugo
ORCID
Venue
BMC Nephrology
Publisher
Springer Science and Business Media LLC
Published
2017-06-17
Volume
18
Issue
1
Pages
198-198
ISSN
1471-2369 (ISSN-L)
DOI
10.1186/s12882-017-0613-7
PMC
PMC5474300
OpenAlex
W2624743454
Cited by
98
References
1
Citations by year
2026: 8 · 2025: 4 · 2024: 10 · 2023: 13 · 2022: 17 · 2021: 14 · 2020: 22 · 2019: 9 · 2017: 1
FWCI
7.83
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • BMC Nephrology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (acceptedVersion, cc-by)
  • Kobe University Repository Kernel (Kobe University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
home-based exercise, aerobic exercise, resistance training, brisk walking, muscle strength, grip strength, quadriceps strength, estimated glomerular filtration rate, physical activity, pedometers, feasibility
MeSH terms
Aged, Exercise Therapy, Feasibility Studies, Renal Dialysis, Home Care Services, Humans, Male, Middle Aged, Treatment Outcome, Renal Insufficiency, Chronic, Muscle Strength, Resistance Training, Accelerometry

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review