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Cited by 13Periodontal Regeneration and TreatmentsTendon Structure and TreatmentFoot and Ankle Surgery

Platelet-rich plasma treatment for talar cartilage repair: a systematic review and meta-analysis

Open access
Peng, Jialei, Wang, Qian, Xu, Yang, He, Hongchen·2023·BMC Musculoskeletal Disorders
DOI 10.1186/s12891-023-06466-yPMC PMC10169378
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Abstract

Purpose: To systematically review the studies regarding to the safety, efficacy and application methods of PRP in promoting the talar cartilage repair. Methods: A systematic review was performed by searching PubMed, Web of Science, OVID and EMBASE to identify studies that compared the clinical efficacy of PRP for talar cartilage repair. Main outcome was the American Orthopedic Foot and Ankle Society (AOFAS) score for function and Visual Analog Scale (VAS) for pain was the second outcome. Results: A total of 10 studies were included in this systematic review, including 4 randomized controlled trials, 1 controlled trial, 3 case series and 2 cohort studies. Four RCTs were analyzed using meta-analysis. For all outcomes, statistical results favored PRP group (AOFAS: MD = 7.84; 95% CI= [-0.13, 15.80], I 2 = 83%, P < 0.01; VAS: MD = 1.86; 95% CI= [0.68, 3.04], I 2 = 85%, P < 0.01). There were almost no reports of adverse events related to PRP intervention. Subgroup analysis showed that whether PRP was used alone or combined with other treatments could result in high heterogeneity but no more specific factors were identified to contribute to this. Conclusion: PRP is safe and effective for talar cartilage repair. In addition to the standardization of PRP preparation and application, it is necessary to distinguish the effects of PRP used alone or in combination with other treatments. In PRP studies, surgical treatment of talar cartilage repair remains the mainstream. The regulation of PRP in surgical applications are worth exploring. The most relative component is the mesenchymal stem cell because it is the only exposed chondrocyte precursor in the articular cavity whether it is microfracture or cell transplantation. Trial registration: The study was registered in the PROSPERO International prospective register of systematic reviews (CRD42022360183).

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  • PRP efficacy in Achilles tendinopathy and knee osteoarthritis has yielded mixed results, with some trials reporting no significant benefit over placebo.

    “PRP’s efficacy in Achilles tendinopathy and knee osteoarthritis has yielded mixed results, with some trials reporting no significant benefit over placebo, underscoring the lack of standardization in PRP preparation [13,95,96].”

    From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [13]

    The Discussion states that PRP preparation lacks standardization, and the Results report no difference between PRP and saline in one ankle study. But the paper does not report mixed placebo-controlled results for Achilles tendinopathy or knee osteoarthritis; its review concerns talar cartilage repair and ankle conditions. (LLM, conf=0.82)

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  • PRP's therapeutic efficacy varies largely due to inconsistent preparation methods and differing platelet concentrations.

    “However, PRP’s therapeutic efficacy varies, largely due to inconsistent preparation methods and differing platelet concentrations, which can significantly influence treatment outcomes [13,14].”

    From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [13]

    The Discussion says PRP preparation lacks standardization and identifies platelet concentration as an area needing investigation. The Results report heterogeneous treatment outcomes, but the paper does not establish that preparation methods and platelet concentrations are largely responsible; its Strengths and limitations section says it could not distinguish the effects of several treatment differences. Page numbers are unavailable in our copy. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Peng, J., Wang, Q., Xu, Y., & He, H.
Affiliations
Sichuan University (CN)
Corresponding author
He, Hongchen
ORCID
Venue
BMC Musculoskeletal Disorders
Publisher
Springer Science and Business Media LLC
Published
2023-05-09
Volume
24
Issue
1
Pages
366-366
ISSN
1471-2474 (ISSN-L)
DOI
10.1186/s12891-023-06466-y
PMC
PMC10169378
OpenAlex
W4376115657
Cited by
13
References
2
Citations by year
2026: 2 · 2025: 7 · 2024: 3 · 2023: 1
FWCI
0.81
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Musculoskeletal Disorders (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Sichuan University
  • West China Hospital, Sichuan University
Topics
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Foot and Ankle Surgery
Keywords
platelet-rich plasma, talus, osteochondral defects, AOFAS score, pain, PRP preparation standardization, mesenchymal stem cells, microfracture, cell transplantation, ankle arthroscopy
MeSH terms
Cartilage, Humans, Joints, Fractures, Stress, Randomized Controlled Trials as Topic, Chondrocytes, Platelet-Rich Plasma

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