The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The effect of fibrin glue on the postoperative lymphatic leakage after D2-lymphadenectomy and gastrectomy in patients with gastric cancer
Open accessPublished version of a preprint
Abstract
Introduction: Disturbance in the lymphatic drainage during D2 dissection is associated with significant morbidity. We aimed to assess the effect of fibrin glue on the reduction of postoperative lymphatic leakage. Methods: Prospective double-blinded randomized clinical trial with forty patients in each study arm was conducted. All patients diagnosed, staged, and became a candidate for D2 dissection based on NCCN 2019 guideline for gastric cancer. The intervention group received 1 cc of IFABOND® applied to the surgical bed. Results: The difference between study groups regarding age, gender, tumor stage was insignificant. (All p-values > 0.05). The median daily drainage volume was 120 ml with the first and the third interquartile being 75 and 210 ml, respectively for the intervention group. The control group had median, the first, and the third interquartile of 350, 290, and 420 ml. The difference between daily drainage volumes was statistically significant (p-value < 0.001). The length of hospital stay was significantly different between the two groups. Notably, the intervention group was discharged sooner (median of 7 Vs 9 days, p-value: 0.001). Conclusion: This study showed the possible role of fibrin glue in reducing postoperative lymphatic leakage after gastrectomy and D2 dissection. Registration trial number: IRCT20200710048071N1, 2020.08.16
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Metadata
- Authors
- Mahmoodzadeh, H., Rahimi-Movaghar, E., Omranipour, R., Shirkhoda, M., Jalaeefar, A., Miri, S. R., & Sharifi, A.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Rahimi-Movaghar, Ehsanollah
- ORCID
- Venue
- BMC Surgery
- Published
- 2021-03-21
- Volume
- 21
- Issue
- 1
- Pages
- 155-155
- ISSN
- 1471-2482 (ISSN-L)
- PMC
- PMC7983227
- OpenAlex
- W3137958004
- Cited by
- 7
- References
- 42
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
- Locations
- BMC Surgery (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Tehran University of Medical Sciences and Health Services
- Topics
- Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Keywords
- fibrin glue, D2 lymph node dissection, gastrectomy, gastric cancer, lymphatic drainage, length of hospital stay
- MeSH terms
- Aged, Double-Blind Method, Female, Gastrectomy, Humans, Lymph Node Excision, Male, Middle Aged, Postoperative Complications, Prospective Studies, Stomach Neoplasms, Fibrin Tissue Adhesive, Treatment Outcome
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- CoChat. (2026). Citation check: The effect of fibrin glue on the postoperative lymphatic leakage after D2-lymphadenectomy and gastrectomy in patients with gastric cancer. https://app.cochat.ai/papers/10.1186/s12893-021-01168-5
- The paper
- Mahmoodzadeh, H., Rahimi-Movaghar, E., Omranipour, R., Shirkhoda, M., Jalaeefar, A., Miri, S. R., & Sharifi, A. (2021). The effect of fibrin glue on the postoperative lymphatic leakage after D2-lymphadenectomy and gastrectomy in patients with gastric cancer. BMC Surgery. https://doi.org/10.1186/s12893-021-01168-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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