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Significance of measuring anthropometric and atherogenic indices in patients with polycystic ovary syndrome
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Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder affecting 5-15% of women of reproductive age, characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology. PCOS is associated with metabolic disturbances such as dyslipidemia, insulin resistance (IR), and an increased risk of type 2 diabetes (T2DM) and cardiovascular disease. OBJECTIVE: The aim of this study is to apply new anthropometric indices [body adiposity index (BAI), visceral adiposity Index (VAI), lipid accumulation product (LAP), body roundness index (BRI), a body shape index (ABSI)] and new atherogenic indices [Castelli index-I, Castelli index-II, atherogenic risk of plasma (AIP), atherogenic coefficient (AC), lipoprotein combined index (LCI), triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio, metabolic score for insulin resistance (METS-IR), triglyceride glucose (TyG) index, triglyceride glucose-dody mass (TyG-BMI) index, triglyceride glucose-waist circumference (TyG-WC) index] metabolic score of insulin resistance to patients with PCOS. METHODS: A retrospective analysis was conducted on 248 women diagnosed with PCOS based on the 2003 Rotterdam criteria. Anthropometric measurements, biochemical parameters, and atherogenic indices were collected from patient records. Statistical analyses were performed using Statistical Package for the Social Sciences software version 28.0. RESULTS: Significant correlations were found between fasting glucose and various anthropometric indices, such as Body mass index (BMI), waist-height ratio (WHtR), and BAI, indicating a link between adiposity and glucose metabolism in PCOS. Atherogenic indices like Castelli's risk indices, AIP, and AC showed positive correlations with glucose and insulin levels, reinforcing their role in assessing cardiovascular risk. Novel indices such as METS-IR and TyG demonstrated strong correlations with both glucose and insulin profiles, highlighting their potential as reliable markers for IR and cardiometabolic risk. CONCLUSION: The study underscores the importance of using a range of anthropometric and atherogenic indices for comprehensive metabolic assessment in women with PCOS. Indices like METS-IR and TyG offer valuable insights into insulin sensitivity and cardiovascular risk, potentially aiding in better management and prognosis of PCOS.
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“Nonetheless, numerous studies, including ours, demonstrate that VAI is a strong indicator for identifying IR(+) and MetS(+) PCOS patients [21].”
From Visceral and Dysfunctional Adiposity Indices as Predictors of Insulin Resistance and Metabolic Syndrome in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study (2025) · cites this paper as [21]
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“Although prior studies have examined the association of VAI with metabolic risk factors, therapeutic outcomes, and IR in PCOS patients, this study is the first to assess the relationship between DAI and both the diagnosis of PCOS and its association with IR and MetS [19,20,21].”
From Visceral and Dysfunctional Adiposity Indices as Predictors of Insulin Resistance and Metabolic Syndrome in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study (2025) · cites this paper as [21]
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Cited by
Keyif, B., & Yavuzcan, A. (2025) · Medicina · doi:10.3390/medicina61030424 · Cited by 11
“Although prior studies have examined the as ‐ sociation of VAI with metabolic risk factors, therapeutic outcomes, and IR in PCOS pa ‐ tients, this study is the first to assess the relationship between DAI and both the diagnosis of PCOS and its association with IR and MetS [19–21].”
Influential
Metadata
- Authors
- Uysal, E., Tammo, O., Soylemez, E., Incebıyık, M., Filiz, D., & Alci, M.
- Affiliations
- Ministry of Health (TR)
- Corresponding author
- Uysal, Emre
- Venue
- BMC Endocrine Disorders
- Published
- 2024-08-28
- Volume
- 24
- Issue
- 1
- Pages
- 160-160
- ISSN
- 1472-6823 (ISSN-L)
- PMC
- PMC11351255
- OpenAlex
- W4401969639
- Cited by
- 23
- References
- 0
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 1
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Endocrine Disorders (publishedVersion, cc-by-nc-nd)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- polycystic ovary syndrome, anthropometric indices, atherogenic index, insulin resistance, triglyceride-glucose index, body adiposity index, visceral adiposity index, lipid accumulation product, body shape index, TC/HDL-C ratio, cardiometabolic risk, dyslipidemia, cardiovascular risk, insulin sensitivity
- MeSH terms
- Adult, Anthropometry, Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Prognosis, Retrospective Studies, Body Mass Index, Adiposity, Atherosclerosis, Waist Circumference, Young Adult
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