Tolerability of endometriosis medical treatment: a comparison between combined hormonal contraceptives and progestins
Open accessPublished version of a preprint
Abstract
Endometriosis is a chronic inflammatory disease that occurs in women of reproductive age. Much of the treatment involves hormone therapy that suppresses the proliferation of endometriosis lesions. Objective To compare discontinuation rates of pharmacological treatment with estrogen-progestins and progestins medications. The secondary objective is to evaluate the main side effects of these drugs in patients with endometriosis. Methods This retrospective study analyzed data from 330 patients who attended the Hospital of the State Public Servant of São Paulo from August 1999 to September 2020 and received pharmacological treatment for endometriosis. The data were obtained by review of the files of medical appointments with specialized staff. Results The median treatment time was 18 months, ranging from 1 to 168 months, and 177 patients interrupted the proposed treatment. The combined contraceptives with estrogens and progestins were significantly linked to treatment interruption, with a relative risk of 1,99 ( p = 0,005). The most important side effects that resulted in treatment interruption were pain persistence ( p = 0,043), weight gain ( p = 0,017) and spotting ( p < 0,001).
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References 29 · Cited by 8
- Authors
- da Costa Pinheiro, D. J. P., Pereira, A. M. G., Antonini, M., Maria Albuquerque Salgado, I., Dias, A. T., & Lopes, R. G. C.
- Affiliations
- Hospital do Servidor Público Estadual (BR)
- ORCID
- Venue
- BMC Women's Health
- Published
- 2023-09-23
- Volume
- 23
- Issue
- 1
- Pages
- 510-510
- ISSN
- 1472-6874 (ISSN-L)
- PMC
- PMC10517511
- OpenAlex
- W4386980854
- Cited by
- 8
- References
- 29
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Women s Health (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, combined hormonal contraceptives, progestins, treatment discontinuation, drug tolerability, adverse drug reactions, pain persistence, weight gain, spotting, hormone therapy
- MeSH terms
- Brazil, Contraceptive Agents, Endometriosis, Female, Humans, Progestins, Retrospective Studies, Drug-Related Side Effects and Adverse Reactions
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